FILIPIN III
- CAS No.
- 480-49-9
- Chemical Name:
- FILIPIN III
- Synonyms
- u-5956;nsc3364;Nsc38092;27-lactone;FILIPIN III;filimarisin;15-Deoxylagosin;1'-epi-Filipin IV;1'-Hydroxyfilipin II;FILIPIN III USP/EP/BP
- CBNumber:
- CB0276061
- Molecular Formula:
- C35H58O11
- Molecular Weight:
- 654.83
- MOL File:
- 480-49-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 163-180° (Bergy, Eble) |
|---|---|
| alpha | D25 -245° (c = 0.8 in DMF) |
| Boiling point | 913.9±65.0 °C(Predicted) |
| Density | 1.161±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in Methanol (up to 10 mg/ml) |
| form | solid |
| pka | 12.77±0.70(Predicted) |
| color | White or light yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RN9800000 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
FILIPIN III price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F4767 | Filipin III from Streptomyces filipinensis ≥85% (HPLC) | 480-49-9 | 1MG | ₹17915.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F4767 | Filipin III from Streptomyces filipinensis ≥85% (HPLC) | 480-49-9 | 5MG | ₹59818.95 | 2022-06-14 | Buy |
FILIPIN III Chemical Properties,Uses,Production
Description
Cholesterol is both an important structural component of cell membranes and an early intermediate in hormone and bile acid biosynthesis. The localization and measurement of cholesterol in cells is therefore of great interest. Filipin is the collective name given to four isomeric polyene macrolides isolated from cultures of S. filipinensis; Filipin III is the predominant isomer and the one used in most studies. Filipin binds to cholesterol in membranes, forming ultrastructural aggregates and complexes which can be visualized by freeze-
Uses
Filipin III is the major component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin III is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin III acts by binding cell membrane sterols, disrupting membrane integrity. This sterol selectivity has led to the use of filipin III as a routine diagnostic probe for quantifying cholesterol in mammalian cells.
Definition
ChEBI: A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
FILIPIN III Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8444 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | China | 9311 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8615350571055 | China | 5848 | 58 | Inquiry |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40067 | 58 | Inquiry |