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Erlotinib D6 HCl

Erlotinib D6 HCl Structure
CAS No.
1189953-78-3
Chemical Name:
Erlotinib D6 HCl
Synonyms
Erlotinib D6;OSI-774 D6 hydrochloride;Erlotiniβ-d6 Hydrochloride;CP-358774 D6 hydrochloride;NSC 718781 D6 hydrochloride;[2H6]-Erlotinib Hydrochloride;Erlotinib Hydrochloride Impurity G
CBNumber:
CB03049808
Molecular Formula:
C22H18ClD6N3O4
Molecular Weight:
435.933630668
MOL File:
1189953-78-3.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:54:57
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Erlotinib D6 HCl Properties

storage temp. Store at -20°C
solubility DMSO: slightly, heated,Methanol: slightly soluble
form A solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Erlotinib D6 HCl Chemical Properties,Uses,Production

Description

Erlotinib-d6 (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.

Uses

Erlotinib D6 HCl is a Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, Antineoplastic.;Labeled Erlotinib, intended for use as an internal standard for the quantification of Erlotinib by GC- or LC-mass spectrometry.

Erlotinib D6 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

Erlotinib D6 HCl Suppliers

Global( 37)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SIMSON PHARMA LIMITED +91-8291074273 Shanghai, India 228 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Guangzhou Dreampharm Biotechnology Co., Ltd. 020-36607679 17825480238 China 9897 12 Inquiry
Supplier Advantage
SIMSON PHARMA LIMITED 58
Pharma Affiliates 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 12

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Erlotinib D6 Erlotinib Hydrochloride Impurity G [2H6]-Erlotinib Hydrochloride CP-358774 D6 hydrochloride NSC 718781 D6 hydrochloride OSI-774 D6 hydrochloride Erlotiniβ-d6 Hydrochloride 1189953-78-3