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Erlotinib hydrochloride

Erlotinib hydrochloride Structure
CAS No.
183319-69-9
Chemical Name:
Erlotinib hydrochloride
Synonyms
ERLOTINIB HCL;Tarceva;ErL;Erlotinib, Hydrochloride Salt;CS-491;OSI 774;RG-1415;CP 358774;NSC718781;RO-0508231
CBNumber:
CB2285915
Molecular Formula:
C22H24ClN3O4
Molecular Weight:
429.9
MOL File:
183319-69-9.mol
Modify Date:
2024/7/11 17:04:31
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Erlotinib hydrochloride Properties

Melting point 223-225°C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 18 mg/ml with warming).
form Yellow powder.
pka pKa (25°): 5.42
color White or off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChIKey GTTBEUCJPZQMDZ-UHFFFAOYSA-N
SMILES C12C=C(OCCOC)C(OCCOC)=CC=1N=CN=C2NC1=CC=CC(=C1)C#C.Cl
CAS DataBase Reference 183319-69-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H413
Precautionary statements  P501-P273
Safety Statements  24/25
HS Code  29335990
NFPA 704
0
3 0

Erlotinib hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Erlotinib hydrochloride (V), a quinazoline derived small molecule inhibitor of epidermal growth factor receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer. It belongs to the same class as gefitinib,another quinazoline approved for treatment of advanced lung cancer, but with improved pharmacokinetic properties. The molecule was originated by Pfizer and development initiated in collaboration with OSI, which assumed full rights to the drug when Pfizer merged with Warner Lambert. Subsequently, Genentech/Roche went into licensing agreement with OSI to develop and market the drug in the US and Worldwide.

Definition

ChEBI: A quinazoline hydrochloride compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.

General Description

Erlotinib is available as 25-, 100-, and 150-mg tablets fororal administration and is used after failure of first-linetherapy in metastatic NSCLC and as first-line therapy incombination with gemcitabine in the treatment of metastaticpancreatic cancer, and in treating malignant gliomas.The structural similarity to gefitnib imparts similar pharmacokineticbehavior with bioavailability of 60% and proteinbinding of 93%. The agent is extensively metabolizedprimarily by CYP3A4. Three major metabolic pathwayshave been identified, involving oxidative-O-demethylationof the side chains followed by further oxidation to give thecarboxlic acids, oxidation of the acetylene functionalityto give a carboxylic acid, and aromatic hydroxylation ofthe phenyl ring para to the electron-donating nitrogen. Themetabolites are primarily eliminated in the feces, and theterminal half-life is 36 hours.The major toxicities seenwith the agent are dose-limiting skin rash and diarrhea.Other common adverse effects include shortness of breath,fatigue, and nausea.

Erlotinib hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Erlotinib

Erlotinib hydrochloride Suppliers

Global( 749)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Dodhia Group +91-9619867345 +91-9619867345 Mumbai, India 129 58 Inquiry
Apotex Pharmachem India Pvt Ltd +91-8022891034 +91-8022891000 Karnataka, India 109 58 Inquiry
Cipla Ltd +912224826000 Maharashtra, India 133 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Shilpa Medicare Limited (SML) +91-8532238704 +91-9320649838 Karnataka, India 61 58 Inquiry
Vannsh Life Sciences Pvt Ltd +91-4023555246 +91-9642555246 Hyderabad, India 15 58 Inquiry
Zyphars Biopharmaceuticals Pvt. Ltd +91-8007587007 +91-8007587007 Mumbai, India 14 58 Inquiry
Basil Drugs AND Pharmaceuticals Pvt Ltd +91-2249700250 +91-9619320820 Mumbai, India 108 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
Dodhia Group 58
Apotex Pharmachem India Pvt Ltd 58
Cipla Ltd 58
Alembic Pharmaceuticals Limited 58
Hetero Drugs Limited 58
Shilpa Medicare Limited (SML) 58
Vannsh Life Sciences Pvt Ltd 58
Zyphars Biopharmaceuticals Pvt. Ltd 58
Basil Drugs AND Pharmaceuticals Pvt Ltd 58

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Erlotinib hydrochloride Spectrum

Erlotinib hydrochloride(183319-69-9)1HNMR

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ERLOTINIB HCL SALT ERLOTINIB HCL SALT :TARCEVA N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine Tarceva Hydrochloride See E625000 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride Erlotinib hydrochloride N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride Erlotinib HCl(TINIBS) erlotinib hydorchloride 6,7-BIS(2-METHOXYETHOXY)-4-(3-ETHYNYLANILINO)QUINAZOLINE HCL Erlotonid HCl 6,7-Bis(2-methoxyethoxy)-4-(3- 21 Erlotinib hydrochloride and Intermediate -(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride Erlotinib, Hydrochloride (Tarceva Hydrochloride) Tarceva Hydrochloride (Erlotinib Hydrochloride) Erlotinib Hydrochloride (Tarceva) Erlotinib, OS-774 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride Tarceva (Erlotinib Hydrochloride) 4-QuinazolinaMine, n-(3-ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-, hydrochloride Erlotinib HCL and InterMediate 4-QuinazolinaMine,N-(3-ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-,hydrochloride(1:1) [6,7-Bis(2-Methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)aMine Hydrochloride CP 358774 N-(3-Ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-4-quinazolinaMine Hydrochloride OSI 774 NSC718781 OSI774;CP-358774;TARCEVA;NSC718781 [6,7-Bis-(2-Methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-aMine.HCl N-(3-Ethynylphenyl)-6,7-bis(2-Methoxyethoxy)quinazolin-4-aMine hydrochloride Erlotinib Hydrochlorid Erlotinib-d6 HCl Erlotinib hydrochloride (SynonyMs CP-358774, OSI-774, NSC 718781) CP-358774-01 RG-1415 RO-0508231 Erlotinib HCl (OSI-744) Erlotinib hydrochloride, 98.5% Tarceva, CP-358774 Erlotinib Hydrochloride WS NSC 718781) HCl Erlotinib hydrochloride N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride Erlotinib HCl, >=99% Erlotinib hydrochlroide Erlotinib (OSI-744) HCl Erlotinib Hcl(CP-358) N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quizolin-4-amine CS-491 Erlotinib-11 Erlotinib Hydrochloride iMpurity 10 Erlotinib (OSI-744) hydrochloride otinib hydrochL Erlotinib hydrochloride USP/EP/BP erlotinib high quali Erlotinib hydrochloride (API)