Anisole
- CAS No.
- 100-66-3
- Chemical Name:
- Anisole
- Synonyms
- METHOXYBENZENE;ANISOL;MOB;METHYL PHENYL ETHER;Anizol;ANISLOE;ANISOLE;Amisale;FEMA 2097;7) ANISOLE
- CBNumber:
- CB5100716
- Molecular Formula:
- C7H8O
- Molecular Weight:
- 108.14
- MOL File:
- 100-66-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/16 16:23:18
| Melting point | -37 °C (lit.) |
|---|---|
| Boiling point | 154 °C (lit.) |
| Density | 0.995 g/mL at 25 °C (lit.) |
| vapor density | 3.7 (vs air) |
| vapor pressure | 10 mm Hg ( 42.2 °C) |
| FEMA | 2097 | ANISOLE |
| refractive index |
n |
| Flash point | 125 °F |
| storage temp. | Store below +30°C. |
| solubility | 1.71g/l |
| form | Liquid |
| color | Clear colorless |
| Relative polarity | 0.198 |
| Odor | phenol, anise odor |
| Odor Threshold | 0.057ppm |
| explosive limit | 0.34-6.3%(V) |
| Odor Type | phenolic |
| Water Solubility | 1.6 g/L (20 ºC) |
| Merck | 14,669 |
| JECFA Number | 1241 |
| BRN | 506892 |
| Dielectric constant | 4.3（20℃） |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. |
| InChIKey | RDOXTESZEPMUJZ-UHFFFAOYSA-N |
| LogP | 2.62 at 30℃ |
| CAS DataBase Reference | 100-66-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, methoxy-(100-66-3) |
| EPA Substance Registry System | Anisole (100-66-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H336 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 10-38-20-36/37 | |||||||||
| Safety Statements | 37/39-26-16-24/25 | |||||||||
| RIDADR | UN 2222 3/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BZ8050000 | |||||||||
| Autoignition Temperature | 887 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Toxicity | LD50 orally in rats: 3700 mg/kg (Taylor) | |||||||||
| NFPA 704 |
|
Anisole price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W209708 | Anisole ≥99%, FCC, FG | 100-66-3 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W209708 | Anisole ≥99%, FCC, FG | 100-66-3 | 1KG | ₹7122.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W209708 | Anisole ≥99%, FCC, FG | 100-66-3 | 10KG | ₹32269.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.01452 | Anisole for synthesis | 100-66-3 | 100ML | ₹5119.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 96109 | Anisole analytical standard | 100-66-3 | 5ML | ₹11193.05 | 2022-06-14 | Buy |
Anisole Chemical Properties,Uses,Production
Description
Anisole is a colorless liquid with a spicy-sweet smell. Anisole can be produced by all the aforementioned methods. It is an important intermediate in the synthesis of organic compounds, for example fragrances and pharmaceuticals. The compound is also used as a solvent and as a heat transfer medium.
Chemical Properties
Anisole is a colorless to yellowish liquid with a characteristic pleasant, anise-like, agreeable, aromatic, spicy-sweet odor. It is used in perfumery.
Occurrence
Anisole is a natural product found in apple juice and in the oil of Artemisia dracunculus var. turkestanica; also reported found in butter, Camembert cheese, roasted beef, olive (Olea europae), Malay apple, Jerusalem artichoke (Helianthus tuberosus), Bourbon vanilla, truffles, crab and sopadilla fruit (Achras sapota L.).
Uses
Anisole is widely used as a solvent for the synthesis of various organic compounds, anethole, nonylphenol isomer 4-(3',6'-dimethyl-3-heptyl)phenol, perfumes, insect pheromones and pharmaceuticals. It finds application in the preparation of inorganic complexes and materials such as tin-core/tin oxide nanoparticles.
Definition
ChEBI: Anisole is a monomethoxybenzene that is benzene substituted by a methoxy group. It has a role as a plant metabolite.
Application
Anisole is an organic compound with the chemical formula C7H8O with a pleasant anise-like aroma, used in organic synthesis and also as a solvent, fragrance and insect repellent. For organic synthesis, it is also used as solvent, fragrance and insect repellent.
Preparation
Anisole is synthesized by reacting phenol and dimethyl sulfate in the presence of aqueous NaOH; by passing methyl chloride into a suspension of sodium phenolate in liquid ammonia.
General Description
A clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Flash point 125°F. Boiling point 307°F. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent.
Air & Water Reactions
Flammable. Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Insoluble in water
Reactivity Profile
Ethers, such as Anisole can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Safety Profile
Moderately toxic by ingestion and inhalation. A skin irritant. A flammable liquid. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid fumes.
Potential Exposure
Anisole is used as a solvent; a flavoring, vermicide, making perfumes; and in organic synthesis.
Purification Methods
Shake anisole with half its volume of 2M NaOH, and the emulsion is allowed to separate. Repeat three times, then wash twice with water, dry over CaCl2, filter, dry over sodium wire and finally distil it from fresh sodium under N2 using a Dean-Stark trap (samples in the trap being rejected until free from turbidity) [Caldin et al. J Chem Soc, Faraday Trans 1 72 1856 1976]. Alternatively dry it with CaSO4 or CaCl2, or by refluxing with sodium or BaO with crystalline FeSO4 or by passage through an alumina column. Traces of phenols are removed by prior shaking with 2M NaOH, followed by washing with water. It has been be purified by zone refining. [Beilstein 6 IV 548.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Anisole Preparation Products And Raw materials
Raw materials
Preparation Products
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|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
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| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
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| SANIKA CHEMICALS PVT.LTD. | +091-22-27572545/27570607 | NaviMumbai, India | 38 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| SUJALAM CHEMICALS | 58 |
| JSK Chemicals | 58 |
| Clean Science and Technology Limited | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Stratechem Pvt Ltd | 58 |
| S D Fine Chem Limited | 58 |
| Emmennar Pharma Pvt Ltd | 58 |
| Westman Chemicals Pvt. Ltd. | 58 |
| SANIKA CHEMICALS PVT.LTD. | 58 |
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