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Cefcapene pivoxil

Cefcapene pivoxil Structure
CAS No.
105889-45-0
Chemical Name:
Cefcapene pivoxil
Synonyms
Fumax;S-1108;Flumax;Cefcapene Piroxil;CEFCAPENE PIVOXIL;Cefcapene Impurity 3;Cefcapene pivoxil USP/EP/BP;Cefcapene Pivoxil Impurities;Cefcapene Pivoxil See C242555;Cefcapene pivoxil Impurity 13
CBNumber:
CB3680908
Molecular Formula:
C23H29N5O8S2
Molecular Weight:
567.64
MOL File:
105889-45-0.mol
Modify Date:
2023/4/23 13:52:06
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Cefcapene pivoxil Properties

Melting point 158-164°C
Boiling point 888.4±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
solubility DMSO, Water( warm)
form Solid
pka 11.33±0.60(Predicted)
color Off-White

Cefcapene pivoxil Chemical Properties,Uses,Production

Description

Flomox was launched in Japan as an orally active cephalosporin for respiratory and urinary tract infections, heptatic infections, ophthalmological and otorhinolarynological infections, skinkoft tissue infections, and for use in gynacology, dentistry and oral surgery. It can be prepared by condesation of 2(Z)-(2-(t-butoxycarbonylamino) thiazol-4-yl)-2-pentenoic acid with 7-amino-3-(carbanoyloxymethyl)- 3-cephem-4-carboxylic acid pivaloyl methyl ester followed by deprotection. Flomox is highly active against a wide variety of Gram-positive and Gram-negative bacteria, except for several strains such as Pseudomonas aeruginosa and enterococci, by acting as a cell wall synthesis inhibitor (β-lactamase stability against TEM-1 type β-lactamases) and is more effective than cefaclor and cefdinir. Absorption is improved by the pivaloyloxymethyl ester group which is easily lost by deesterification during GI absorption to produce the biologically active form. The pivalic acid generated quickly conjugates with carnitine and is excreted in the urine. The drop in plasma levels of carnitine was dose dependent and returned to normal levels upon termination of treatment.

Chemical Properties

Off-White Solid

Cefcapene pivoxil Preparation Products And Raw materials

Raw materials

Phosphoric acid Anisole Trifluoroacetic acid Methanesulfonyl chloride Iodomethane

Preparation Products

Cefcapene pivoxil Suppliers

Global( 112)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Akums Lifesciences Ltd +91-1147511000 +91-1147511000 New Delhi, India 38 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
MS Pharmachem 08048371669Ext 537 Mumbai, India 13 58 Inquiry
COVALENT LABORATORIES PRIVATE LIMITED +91-40-49483333 New Delhi, India 10 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
SL Drugs and Pharmaceuticals Pvt. Ltd. +91 (40) 6661-1133 New Delhi, India 2683 50 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21628 55 Inquiry
Xiamen AmoyChem Co., Ltd +86-86-5926051114 +8615060885618 China 6383 58 Inquiry
Supplier Advantage
Akums Lifesciences Ltd 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
MS Pharmachem 58
COVALENT LABORATORIES PRIVATE LIMITED 58
Pharma Affiliates 58
SL Drugs and Pharmaceuticals Pvt. Ltd. 50
Capot Chemical Co.,Ltd. 60
Henan Tianfu Chemical Co.,Ltd. 55
Xiamen AmoyChem Co., Ltd 58

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(6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester Fumax S-1108 Cefcapene Piroxil Flumax CEFCAPENE PIVOXIL Cefcapene Pivoxil See C242555 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-1-oxo-2-penten-1-yl]aMino]-8-oxo-,(2,2-diMethyl-1-oxopropoxy)Methyl ester, (6R,7R)- (6R,7R)-7-[[(Z)-2-(2-amino-4-thiazolyl)-1-oxopent-2-enyl]amino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester Cefcapene Impurity 3 (6R,7R)-(pivaloyloxy)methyl7-((Z)-2-(2-aminothiazol-4-yl)pent-2-enamido)-3-((carbamoyloxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cefcapene pivoxil USP/EP/BP Cefcapene Pivoxil Impurities Cefditoren pivoxilQ: What is Cefditoren pivoxil Q: What is the CAS Number of Cefditoren pivoxil Q: What is the storage condition of Cefditoren pivoxil Q: What are the applications of Cefditoren pivoxil 105889-45-0 Cefcapene pivoxil Cefcapene pivoxil Powder USP Standard Cefcapene pivoxil Impurity 13 105889-45-0 Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Heterocycles Metabolites & Impurities Sulfur & Selenium Compounds Pharmaceutical intermediate