Kresoxim-methyl
- CAS No.
- 143390-89-0
- Chemical Name:
- Kresoxim-methyl
- Synonyms
- STROBY;KresoxiM-Methy;(E)-Methyl 2-(MethoxyiMino)-2-(2-((o-tolyloxy)Methyl)phenyl)acetate;Cygnus;MENTOR;Candit;ALLEGRO;Strob 1;BAS 490F;Stroby WG
- CBNumber:
- CB6353737
- Molecular Formula:
- C18H19NO4
- Molecular Weight:
- 313.35
- MOL File:
- 143390-89-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:14
| Melting point | 98-100°C |
|---|---|
| Boiling point | 429.4±47.0 °C(Predicted) |
| Density | 1.28 |
| vapor pressure | 2.3 x 10-6 P a (20 °C) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
| form | Liquid |
| Water Solubility | 2 mg l-1(20 °C) |
| color | Colorless to light yellow |
| Specific Gravity | 1.28 (20℃) |
| BRN | 8330581 |
| InChIKey | ZOTBXTZVPHCKPN-HTXNQAPBSA-N |
| LogP | 3.44 at 25℃ |
| Surface tension | 72.8mN/m at 1.8mg/L and 20℃ |
| CAS DataBase Reference | 143390-89-0(CAS DataBase Reference) |
| EPA Substance Registry System | Kresoxim-methyl (143390-89-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Hazard Codes | Xn;N,N,Xn |
| Risk Statements | 40-50/53 |
| Safety Statements | 2-36/37-60-61 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 3 |
| HS Code | 29252900 |
| Toxicity | LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Ammerman) |
Kresoxim-methyl Chemical Properties,Uses,Production
Description
Kresoxim-methyl is a strobilurin fungicide. It inhibits conidial germination of V. inaequalis isolates from apple orchards (EC50s = 0.00033-0.0078 mg/L). Kresoxim-methyl also inhibits mycelial growth (EC50 = 0.240 mg/L) and is fungicidal against Saprolegnia (MIC = 1 mg/L). It increases intracellular calcium levels and disrupts the mitochondrial membrane potential in mouse cortical cultures in a concentration-dependent manner. Kresoxim-methyl is toxic to goldfish (C. auratus; LC50 = 0.807 mg/L).
Uses
Kresoxim-methyl is used for the control of several diseases (scab, mildews, blast, sheath blight and others) on a range of crops including apples, pears, vines, sugar beet and cereals.
Definition
ChEBI: A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops.
Hazard
Moderately toxic by skin contact. Low tox-icity by ingestion and inhalation.
Safety Profile
Moderately toxic by skin contact. Low toxicity by ingestion and inhalation. Questionable carcinogen with experimental data reported. When heated to decomposition it emits toxic vapors of NOx.
Metabolic pathway
By hepatocyte suspensions prepared from goats, pigs, hens, and rats that have been cryopreserved and thawed, BAS 490 F is metabolized via the same pathways as observed using fresh rat hepatocytes. The rate of hydrolysis of 14C-BAS 490 F leading to a carboxylic acid derivative seems to be constant between the cryopreserved and fresh hepatocytes except for goats. The oxidation reaction at the methyl group of the phenoxy ring, leading to the hydroxymethyl analog of the carboxylic acid of BAS 490 F, significantly decreases after cryopreservation, whereas the formation of (E)-2-methoxyimino-2[2-(4- hydroxy-2-methylphenyloxymethyl)phenyl] acetic acid by hydroxylation at the 4-position of the phenoxy ring remains at a constant rate. In pig hepatocytes, the two hydroxylated metabolites of the phenoxy ring, carboxy BAS 409 F and (E)-2-methoxyimino-2-o- hydroxymethylphenyl acetic acid, are formed to a lesser extent after cryopreservation.
Metabolism
Kresoxim-methyl is rapidly metabolized in mammalian systems to the virtually inactive carboxylic acid, accounting for its low toxicity and high level of selectivity. Atharvest residues in cereals and top fruit are <0.05 mg/kg and <1 mg/kg in grapes and vegetables. The soil DT50 = <3 days, and the Koc is 219 to 372. For the main metabolite, the Koc is 17 to 24. Hydrolytic stability tests indicate a DT50 of 34 days at pH 7 but only 7 h at pH 9.
Kresoxim-methyl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Parijat Industries India Private Limited | 08048372460Ext 265 | Delhi, India | 19 | 58 | Inquiry |
| Qingdao Trust Agri Chemical Co.,Ltd | +8613573296305 | China | 213 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
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