α-Lipoic Acid
- CAS No.
- 1077-28-7
- Chemical Name:
- α-Lipoic Acid
- Synonyms
- ALA;THIOCTIC ACID;ALPHA-LIPOIC ACID;ALPHA-LIPOIC ACID;DL-THIOCTIC ACID;Thioctic acid CRS;A-LIPOIC ACID;alpha lipoic acid powder;DL-A-LIPOIC ACID;Alpha Acid Lipoic
- CBNumber:
- CB5180699
- Molecular Formula:
- C8H14O2S2
- Molecular Weight:
- 206.33
- MOL File:
- 1077-28-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/12 15:32:57
| Melting point | 60-62 °C |
|---|---|
| Boiling point | 160-165 °C(lit.) |
| Density | 1.2888 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Flash point | 160-165°C |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL |
| form | Crystals or Crystalline Powder |
| pka | 4.75±0.10(Predicted) |
| color | Yellow |
| Water Solubility | 0.9 g/L (20 ºC) |
| Merck | 14,9326 |
| BRN | 81853 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| LogP | 2.530 (est) |
| CAS DataBase Reference | 1077-28-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Dl-thioctic acid(1077-28-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H411 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 37/39-26-24/25-36-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JP1192000 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
α-Lipoic Acid price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T5625 | (±)-α-Lipoic acid synthetic, ≥99% (titration), powder | 1077-28-7 | 500MG | ₹1872.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5625 | (±)-α-Lipoic acid synthetic, ≥99% (titration), powder | 1077-28-7 | 1G | ₹3820 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5625 | (±)-α-Lipoic acid synthetic, ≥99% (titration), powder | 1077-28-7 | 5G | ₹10220 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5625 | (±)-α-Lipoic acid synthetic, ≥99% (titration), powder | 1077-28-7 | 25G | ₹19540 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5625 | (±)-α-Lipoic acid synthetic, ≥99% (titration), powder | 1077-28-7 | 50G | ₹35105.48 | 2022-06-14 | Buy |
α-Lipoic Acid Chemical Properties,Uses,Production
Description
DL-
Chemical Properties
Light-Yellow Solid
Uses
(±)-α-Lipoic acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay. It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.
General Description
Oxidized form. Has antioxidant properties. Growth factor for many bacteria and protozoa.
Pharmaceutical Applications
Lipoic acid(ALA), also known as α-lipoic acid (alpha-lipoic acid) or thioctic acid, has the formula C8H14S2O2 and
systematic name 5-(1,2-dithiolan-3-yl)pentanoic acid. It contains a disulfide group, which can be transformed
in the body to a dithiol group.
ALA has been on the market since the 1950s as a dietary supplement. It is a natural antioxidant usually
made by the body. The advantage of ALA over other antioxidants such as vitamin C and E is that it is soluble
both in water and in fat. Researchers in the former Soviet Union found that ALA can chelate mercury
once it is transformed into the dithiol-containing compound. ALA can penetrate both the blood–brain barrier
and the cell membrane and therefore would be a very interesting chelating agent. Nevertheless, there is much
debate about its mode of action, side effects and effectiveness. Other antidotes, such as BAL and DMSA, are
more efficient in the removal of heavy metals. ALA has not received FDA approval as a chelating agent, but
it is still sold as a food supplement.
Purification Methods
It forms yellow needles from cyclohexane or hexane and has been distilled at high vacuum; and sublimes at ~90o and very high vacuum. It is insoluble in H2O but dissolves in alkaline solution. [Lewis & Raphael J Chem Soc 4263 1962, Soper et al. J Am Chem Soc 76 4109, Reed & Niu J Am Chem Soc 77 416 1955, Tsuji et al. J Org Chem 43 3606 1978, Calvin Fed Proc USA 13 703 1954.] The S-benzylisothiuronium salt has m 153-154o (evacuated capillary, from MeOH), 132-134o, 135-137o (from EtOH). The dand lforms have m 45-47.5o and [] D 23 ±113o (c 1.88, *C6H6) and have UV in MeOH with max at 330nm ( 140). [Beilstein 19/7 V 237.] The reduced form, (±)-6,8-dimercaptooctanoic acid, [7516-48-5] M 208.3, is a light yellow liquid which is sold in sealed ampoules.
α-Lipoic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TAGOOR LABORATORIES PVT LTD | +919700187008 | AndhraPradesh, India | 93 | 58 | Inquiry |
| Veer Pharmachem | +91-02645661117 +91-9879471589 | Gujarat, India | 39 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Stabicoat Vitamins | +91-9376122600 +91-9825493831 | Gujarat, India | 4 | 58 | Inquiry |
| Goalsy Laboratories | +91-8247562464 +91-8247562464 | Hyderabad, India | 2 | 58 | Inquiry |
| Vanquest Pharma Pvt Ltd | +91-9920897640 +91-9920897640 | Mumbai, India | 36 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Fido Pharma | +91-9876274767 +91-9167231289 | Haryana, India | 23 | 58 | Inquiry |
| Paras Organics Pvt Ltd | +91-9372775279 +91-9867239238 | Maharashtra, India | 9 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TAGOOR LABORATORIES PVT LTD | 58 |
| Veer Pharmachem | 58 |
| Medi Pharma Drug House | 58 |
| Stabicoat Vitamins | 58 |
| Goalsy Laboratories | 58 |
| Vanquest Pharma Pvt Ltd | 58 |
| Merck Ltd | 58 |
| Fido Pharma | 58 |
| Paras Organics Pvt Ltd | 58 |
| Meteoric Biopharmaceuticals Pvt. Ltd. | 58 |
Related articles
- α-Lipoic Acid: Chemistry and Pharmacodynamics in Diabetes Mellitus
- α-Lipoic Acid improves vascular health, reduces oxidative stress, and mitigates diabetic complications, showing potential for ....
- Jun 7，2024
- α-Lipoic acid: pharmacokinetics and activities
- α-Lipoic acid exhibits a wide range of potential health benefits, including antioxidant activity, antidiabetic effects, and an....
- Jul 20，2023
- Systhesis of Lipoic acid
- α- Lipoic acid is light yellow powder crystal, almost tasteless Low solubility in water, about 1 g / L (20 ° C) Soluble in 10%....
- Dec 31，2021
Related Qustion
- Q:Which foods include α-Lipoic Acid?
- A:?α-Lipoic Acid is an antioxidant made naturally in the body and found in foods. It is used to break down carbohydrates and to ....
- Jun 5，2024
1077-28-7(α-Lipoic Acid)Related Search:
1of4
chevron_right