Dimethyl sulfate
- CAS No.
- 77-78-1
- Chemical Name:
- Dimethyl sulfate
- Synonyms
- DIMETHYL SULPHATE;METHYL SULFATE;Dimetilsolfato;Dimethylsulfat;Methylsulphate;DMS (Methyl sulfate);Dimethyl monosulfate;NSC 56194;ai3-52118;Methanesulfate
- CBNumber:
- CB9854316
- Molecular Formula:
- C2H6O4S
- Molecular Weight:
- 126.13
- MOL File:
- 77-78-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:33
| Melting point | -32 °C |
|---|---|
| Boiling point | 188 °C(lit.) |
| Density | 1.333 g/mL at 25 °C(lit.) |
| vapor density | 4.3 (vs air) |
| vapor pressure | 0.7 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 182 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: 0.26 g/mL, clear, colorless |
| form | Liquid |
| color | Clear colorless |
| Odor | Almost odorless |
| Water Solubility | 2.8 g/100 mL (18 ºC) |
| Merck | 13,3282 |
| BRN | 635994 |
| Exposure limits | TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH). |
| Dielectric constant | 55.0（20℃） |
| Stability | Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive. |
| CAS DataBase Reference | 77-78-1(CAS DataBase Reference) |
| IARC | 2A (Vol. 4, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Sulfuric acid, dimethyl ester(77-78-1) |
| EPA Substance Registry System | Dimethyl sulfate (77-78-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H314-H317-H330-H341-H350 | |||||||||
| Precautionary statements | P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 45-25-26-34-43-68 | |||||||||
| Safety Statements | 53-45-61 | |||||||||
| RIDADR | UN 1595 6.1/PG 1 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.1 ppm (0.5 mg/m3) [skin] | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WS8225000 | |||||||||
| F | 21 | |||||||||
| Autoignition Temperature | 495 °C | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29209090 | |||||||||
| Toxicity | LD50 orally in rats: 440 mg/kg (Smyth) | |||||||||
| IDLA | 7 ppm | |||||||||
| NFPA 704 |
|
Dimethyl sulfate Chemical Properties,Uses,Production
Description
Dimethyl sulfate is a colorless, oily liquid with a faint, onionlike
odor. It is soluble in water, ether, dioxane, acetone,
benzene, and other aromatic hydrocarbons, miscible with
ethanol, and sparingly soluble in carbon disulfide. It is stable
under normal temperatures and pressures, but hydrolyzes
rapidly in water at or above 18 ℃.
Dimethyl sulfate has been produced commercially since at
least the 1920s. One production method is continuous reaction
of dimethyl ether with sulfur trioxide. In 2009, dimethyl sulfate
was produced by 33 manufacturers worldwide, including 1 in
the United States, 14 in China, 5 in India, 5 in Europe, 6 in East
Asia, and 2 in Mexico, and was available from 44 suppliers,
including 16 US suppliers. There are no data on US imports or
exports of dimethyl sulfate. Reports filed from 1986 through
2002 under the US Environmental Protection Agency’s Toxic
Substances Control Act Inventory Update Rule indicate that US
production plus imports of dimethyl sulfate totaled 10–50
million pounds. The simplest way of synthesizing dimethyl
sulfate is by esterification of sulfuric acid with methanol as
follows:2CH3OH+ H2SO4→(CH3)2SO4 + 2H2O
Chemical Properties
Dimethyl sulfate is essentially odorless. The specific gravity of this colorless, corrosive, oily liquid is 1.3322 g/cm3. Dimethyl sulfate is soluble in ether, dioxane, acetone, benzene, and other aromatic hydrocarbons. It is sparingly soluble in carbon disulfide and aliphatic hydrocarbons, and only slightly soluble in water (28 g/l at 18 °C) (O'Neil, 2006).
Uses
Dimethyl sulfate is a strong alkylating agent and might also react with the carboxylic acid substrate, further reducing the DMS concentration in the mixture. It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.
Preparation
Dimethyl sulfate is prepared by distillation of an oleum/methanol mixture; technical production using dimethyl ether and SO3 has also been reported (NLM, 2013).
Definition
ChEBI: Dimethyl sulfate is the dimethyl ester of sulfuric acid. It has a role as an alkylating agent and an immunosuppressive agent.
Application
Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions.
General Description
Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.
Air & Water Reactions
Water soluble.
Reactivity Profile
Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].
Health Hazard
Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.
Flammability and Explosibility
Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.
Carcinogenicity
Dimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Chemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)
storage
work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.
Incompatibilities
Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.
Waste Disposal
Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.
Dimethyl sulfate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| sheetalchemicals | +91-9820130159 +91-9820130159 | Maharashtra, India | 77 | 58 | Inquiry |
| REVIN LABS PRIVATE LIMITED | +91-04029881685 +91-9989320685 | Telangana, India | 12 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Globus Pharmachem (Para Products Pvt Ltd) | +91-1204198900 +91-9899370547 | Uttar Pradesh, India | 22 | 58 | Inquiry |
| BanChem Group | +91-9321395999 +91-9769361999 | Maharashtra, India | 26 | 58 | Inquiry |
| Guljag Industries Limited | +91-9772500432 +91-9649049000 | Maharashtra, India | 11 | 58 | Inquiry |
| Industrial Solvents And Chemicals Pvt Ltd | +91-2222841180 +91-9819294980 | Maharashtra, India | 9 | 58 | Inquiry |
| Ganesh PolyChem Limited | +91-9820626284 | Maharashtra, India | 2 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANJI BIOSCIENCES | 58 |
| sheetalchemicals | 58 |
| REVIN LABS PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| CNS CHEMICALS | 58 |
| Globus Pharmachem (Para Products Pvt Ltd) | 58 |
| BanChem Group | 58 |
| Guljag Industries Limited | 58 |
| Industrial Solvents And Chemicals Pvt Ltd | 58 |
| Ganesh PolyChem Limited | 58 |
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