Dimethyl fumarate
- CAS No.
- 624-49-7
- Chemical Name:
- Dimethyl fumarate
- Synonyms
- Methyl fumarate;Dimethyl fumaratedisc. 10/26/00;tl353;BG-12);Dimethylfumarat;imethylfumarate;BIS-METHYL ESTER;dimethylfumalate;TwoMethylfuMarate;Dimethylefumarate
- CBNumber:
- CB6712800
- Molecular Formula:
- C6H8O4
- Molecular Weight:
- 144.13
- MOL File:
- 624-49-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/30 16:33:02
| Melting point | 102-106 °C (lit.) |
|---|---|
| Boiling point | 192-193 °C (lit.) |
| Density | 1,37 g/cm3 |
| vapor pressure | 5 hPa (25 °C) |
| refractive index | 1.4062 (estimate) |
| Flash point | 192-193°C |
| storage temp. | Store below +30°C. |
| solubility | 1.6g/l |
| form | Liquid |
| color | Clear colorless to faintly yellow |
| PH | 4.0-6.0 (10g/l, H2O, 20℃)suspension |
| Water Solubility | Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml). |
| Merck | 14,4287 |
| BRN | 774590 |
| Stability | Stable. Incompatible with acids, bases, oxidizing agents, reducing agents. |
| CAS DataBase Reference | 624-49-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Butenedioic acid (E)-, dimethyl ester(624-49-7) |
| EPA Substance Registry System | 2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312-H315-H317-H335-H411 | |||||||||
| Precautionary statements | P261-P264-P271-P273-P280-P302+P352+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 21-38-41-43-36/37/38-36/38 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | EM6125000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29171990 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg | |||||||||
| NFPA 704 |
|
Dimethyl fumarate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 242926 | Dimethyl fumarate 97% | 624-49-7 | 25G | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50744 | Dimethyl fumarate certified reference material, TraceCERT? | 624-49-7 | 100MG | ₹9504.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 242926 | Dimethyl fumarate 97% | 624-49-7 | 100G | ₹4070.2 | 2022-06-14 | Buy |
| ALFA India | ALF-A10402-30 | Dimethyl fumarate, 99% | 624-49-7 | 250g | ₹8149 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0069 | Dimethyl Fumarate min. 98.0 % | 624-49-7 | 25G | ₹2100 | 2022-05-26 | Buy |
Dimethyl fumarate Chemical Properties,Uses,Production
Description
In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.
Chemical Properties
fine white crystalline powder
Uses
Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing
Definition
ChEBI: Dimethyl fumarate is an enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis. It has a role as an immunomodulator and an antipsoriatic. It is an enoate ester, a methyl ester and a diester. It is functionally related to a methanol and a fumaric acid.
General Description
Dimethyl fumarate is a novel oral therapeutic agent, which can be used for patients suffering from relapsing-remitting multiple sclerosis. It shows an effective inhibition of mould in bread and can also serve as a potential candidate for the treatment of psoriasis, a chronic autoimmune condition.
Contact allergens
Dimethylfumarate, a strong irritant, is used as an industrial wide spectrum biocide in Asia and mainly in China, for textiles, leather, seeds, food, and cosmetic ingredients. It provoked a worldwide epidemic of severe contact dermatitis, initially from Chinese sofas sold in Finland, Great Britain, and France. It also induced severe burning and contact allergy due to shoes, and to contaminated clothing as well. This chemical, presents as is (white powder) or as tablets contained in little bags disposed in/or around the materials to protect, progressively evaporates and contaminates the environment. It is forbidden in the European Union since 2008
Dimethyl fumarate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| Sekhment pharmaventures | +91-9030088669 +91-9030088669 | Mumbai, India | 105 | 58 | Inquiry |
| Lofty labs | +91-7673920392 +91-7673920392 | Telangana, India | 32 | 58 | Inquiry |
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| Dishman Carbogen Amcis Ltd (Dishman Group) | +91-2717420100 +91-8154017093 | Gujarat, India | 90 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Unichem Laboratories Ltd | +91-2266888333 +91-2266888333 | Maharashtra, India | 62 | 58 | Inquiry |
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