Ketotifen fumarate
- CAS No.
- 34580-14-8
- Chemical Name:
- Ketotifen fumarate
- Synonyms
- Ketotifene fumarate;4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate;zaditor;zaditen;ketotifen fuMarat;10H-Benzo4,5cyclohepta1,2-bthiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1);4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one hydrogen (E)-butenedioate;Zasten;Totifen;Anatifen
- CBNumber:
- CB5463479
- Molecular Formula:
- C23H23NO5S
- Molecular Weight:
- 425.5
- MOL File:
- 34580-14-8.mol
- Modify Date:
- 2024/9/10 19:09:04
| Melting point | 192 C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile. |
| form | Solid |
| color | White to Pale Beige |
| PH | pH (10g/l, 25℃) : 3.0～4.0 |
| Water Solubility | Soluble in water (10 mg/ml), DMSO (100 mM), and methanol. |
| λmax | 297nm(MeOH)(lit.) |
| Merck | 14,5307 |
| InChIKey | YNQQEYBLVYAWNX-WLHGVMLRSA-N |
| CAS DataBase Reference | 34580-14-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36/37/38-23/24/25 | |||||||||
| Safety Statements | 36-45-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DE8260000 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992. | |||||||||
| NFPA 704 |
|
Ketotifen fumarate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | K2628 | Ketotifen fumarate salt | 34580-14-8 | 100MG | ₹4459.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K2628 | Ketotifen fumarate salt | 34580-14-8 | 1G | ₹23804.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | K0048 | Ketotifen Fumarate | 34580-14-8 | 1G | ₹7500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | K0048 | Ketotifen Fumarate | 34580-14-8 | 5G | ₹10000 | 2022-05-26 | Buy |
Ketotifen fumarate Chemical Properties,Uses,Production
Description
Ketotifen is a histamine H1 receptor antagonist (Ki = 1.3 nM) and mast cell stabilizer. It is selective for H1 receptors over H2 and H3 receptors (Kis = 987 and 2,500 nM, respectively). Ketotifen (50 and 100 μM) inhibits degranulation of rat peritoneal mast cells induced by compound 48/80 . It inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats by 54.6% when administered orally at a dose of 20 mg/kg. Ketotifen (30 mg/kg) inhibits the quick phase airway response in a rat ovalbumin-induced immediate airway response model. Formulations containing ketotifen have been used in the treatment of itching associated with allergic conjunctivitis.
Chemical Properties
Off-White Solid
Uses
Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water
General Description
Ketotifen fumarate, 4-(1-methyl-4-piperidylidene)-4Hbenzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogenfumarate (Zaditor), is a fine crystalline powder.Ketotifen is a ketothiophene isostere analog of the dibenzocycloheptaneantihistamines. The solution contains0.345 mg of ketotifen fumarate, which is equivalent to0.25 mg of ketotifen. The solution also contains the preservativebenzalkonium chloride (0.01%) as well as glycerol,sodium hydroxide and/or hydrochloric acid (to adjust pH),and purified water. It has a pH of 4.4 to 5.8 and an osmolalityof 210 to 300 mOsm/kg.
The recommended dose of ketotifen solution is 1 drop instilledinto each affected eye every 8 to 12 hours. The mostfrequently reported adverse reactions are conjunctival infection,headaches, and rhinitis. This drug product is for ocularadministration only and not for injection or oral use.Ketotifen solution should be used with caution during pregnancyor while nursing, because its safety has not been studiedunder these circumstances.
Biological Activity
An H 1 receptor antagonist.
Ketotifen fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Fleming Laboratories Ltd | +91-9666407333 +91-9666022445 | Hyderabad, India | 22 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| SETV ASRV LLP | +91-9731133411 +91-9731133411 | Telangana, India | 531 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Festiva Pharma | 08048372775Ext 728 | Gujarat, India | 238 | 58 | Inquiry |
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