KETOTIFEN

CAS No.: 34580-13-7

Chemical Name:: KETOTIFEN

Synonyms: hc20-511;HC 20-511;KETOTIFEN;Ketotifeno;idinylidene)-;hiophen-10-one;Ketotifen base;KETOTIFENFUMARATC;Ketotifen Fumaratic;Ketotifen Free Base

CBNumber:: CB9249738

Molecular Formula:: C19H19NOS

Molecular Weight:: 309.43

MOL File:: 34580-13-7.mol

MSDS File:: SDS

Modify Date:: 2025/2/25 18:47:31

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KETOTIFEN Properties

Melting point	152-153℃
Boiling point	488.9±45.0 °C(Predicted)
Density	1.236
storage temp.	Amber Vial, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
pka	8.84±0.20(Predicted)
form	Solid
color	Light Yellow to Orange
InChI	InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
InChIKey	ZCVMWBYGMWKGHF-UHFFFAOYSA-N
SMILES	C12C(=O)CC3=CC=CC=C3/C(=C3/CCN(C)CC/3)/C=1C=CS2
EPA Substance Registry System	Ketotifen (34580-13-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
HS Code	29349990
Hazardous Substances Data	34580-13-7(Hazardous Substances Data)

KETOTIFEN Chemical Properties,Uses,Production

Uses

Ketotifen is an intermediate in the synthesis of Ketotifen N-Oxide Hydrochloride (K315410), which is a metabolite of Ketotifen (K315100) in humans; formed by human liver microsome. For the free base, see K315115.

General Description

Crystals (from ethyl acetate).

Fire Hazard

Flash point data for KETOTIFEN are not available. KETOTIFEN is probably combustible.

Clinical Use

Ketotifen is a potent, selective H1 antihistamine that also prevents release of transmitters from mast cells. It is approved in the United States for topical use to prevent itching of the eye because of allergic conjunctivitis, It is used as a systemic antiallergy agent in several countries outside the United States for the treatment of seasonal allergic rhinitis, hay fever, and asthma. Being structurally analogous to the cyproheptadine-like antihistamines, differences in activity of the two enantiomers (atropisomers) has been noted, being approximately six- to seven-fold in ligand displacement and rodent-based assays. Ketotifen has been shown to stabilize mast cells and to inhibit degranulation of eosinophils. Like olopatadine, it has been shown to interact with model membranes, stabilizing them by interaction with phospholipids monolayers.

KETOTIFEN Preparation Products And Raw materials

Raw materials

Magnesium Hydrochloric acid 4-Chloropiperidine hydrochloride 10-METHOXY-4H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHEN-4-ONE

Preparation Products

9,10-Dioxo Ketotifen

KETOTIFEN Suppliers

Global( 90)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	532-83657313 18663969289;	China	227	58	Inquiry
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210 +86-13129979210	China	376	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34563	58	Inquiry
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	CHINA	9414	58	Inquiry

Supplier	Advantage
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	58
Wuhan Cell Pharmaceutical Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Baoji Guokang Healthchem co.,ltd	58

34580-13-7(KETOTIFEN)Related Search:

KETOTIFEN HYDROGEN FUMARATE - REFERENCE SPECTRUM KETOTIFEN FUMARATE (N/H) KETOTIFEN IMPURITY G4-(1-METHYLPIPERIDIN-4-YLIDENE)-4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIPHEN-9,10-DIONE EPY(CRM STANDARD) KETOTIFEN HYDROGEN FUMARATE MM(CRM STANDARD) Ketotifen USP24 BP2000

KETOTIFEN IMPURITY G KETOTIFEN HYDROGEN FUMARATE 10-methoxy-4H-benzo[4,5]-cycloheta[1,2-b]thiophen-4-one(for Ketotifen) KETOTIFEN MM(CRM STANDARD) KETOTIFEN HYDROGEN FUMARATE REFERENCE SPECTRUM EPY(CRM STANDARD)

KETOTIFEN FUMARATE SALT,KETOTIFEN FUMARATE,KETOTIFEN FUMARATE EP 3-BENZYLTHIOPHENE Etolotifen Pizotifen IBD 78

KETOTIFEN

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KETOTIFEN 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piper 4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10h-benzo(4,5)cyclohepta(1,2-b)t 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one HC 20-511 hc20-511 hiophen-10-one idinylidene)- Ketotifen Fumaratic KETOTIFENFUMARATC 4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one Ketotifen base Ketotifeno 4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one Ketotifen Free Base 34580-13-7 C19H19NOS API's