Ketotifen fumarate
Ketotifen fumarate
- CAS:
- 34580-14-8
- MF:
- C23H23NO5S
- MW:
- 425.5
Suppliers by country/region
- India(29)
- CHINA(206)
- United States(53)
- United Kingdom(19)
- Canada(4)
- Germany(7)
- Europe(2)
- Switzerland(2)
- Japan(2)
- Belgium(2)
- Uruguay(1)
- Austria(1)
- Italy(1)
- Egypt(2)
- Mexico(1)
- South Korea(1)
- Spain(1)
- Greece(1)
- The Netherlands(1)
- Brazil(3)
- France(2)
- Venezuela(1)
- Poland(1)
- Malaysia(1)
- United Arab Emirates(1)
Company Type
Properties
- Melting point:
- 192 C
- storage temp.
- 2-8°C
- solubility
- Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile.
- form
- Solid
- color
- White to Pale Beige
- PH
- pH (10g/l, 25℃) : 3.0～4.0
- Water Solubility
- Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
- λmax
- 297nm(MeOH)(lit.)
- Merck
- 14,5307
- InChIKey
- YNQQEYBLVYAWNX-WLHGVMLRSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H319
- Precautionary statements
- P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
- Hazard Codes
- Xn,T
- Risk Statements
- 22-36/37/38-23/24/25
- Safety Statements
- 36-45-36/37/39-26
- WGK Germany
- 3
- RTECS
- DE8260000
- HS Code
- 29349990
- Toxicity
- child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992.
Use
Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. It also has antagonism effect on the calcium ion; can inhibit the activity of phosphodiesterase; increase the intracellular cAMP level inside mast cells. Moreover, it can also inhibiting the chemotaxis and inflammation of neutrophil with an effect 10 times as strong as that of chlorpheniramine, and it also has a long duration time which is better compared with sodium cromolyn. Ketotifen fumarate has therapeutic effect on both Ⅰ and Ⅲ type of allergic reaction. Its peak blood concentrations can sustain for 2 to 3 hours with a half-life of 22 hours during which 60% goes through urinary excretion, 40% goes through the fecal excretion. Children usually have a faster excretion rate of it than adults. Long-term treatment will not cause resistance. No rebound phenomenon will occur with interruption of treatment.
29 India supplier list of "Ketotifen fumarate "
- Product Name:Ketotifen fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:KETOTIFEN FUMARATE
- Products Intro:Purity: 95-99 % | Package: 1-5 gm, the rest upon order
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Ketotifen fumarate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Ketotifenfumaratesalt
- Products Intro:Brand:sigma aldrich | Product Number:K2628
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Ketotifen fumarate 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.131326
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:KetotifenFumarate
- Products Intro:Brand:synzeal | Product Number:199293251
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Ketotifen Fumarate
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
- Product Name:Ketotifen fumarate
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Ketotifen fumarate
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:KetotifenFumarate
- Products Intro:Brand:tcichemicals | Product Number:K0048
- Company Type: Reagent
- Country/Region: New Delhi,INDIA