Dimethyl fumarate
Dimethyl fumarate
- CAS:
- 624-49-7
- MF:
- C6H8O4
- MW:
- 144.13
Suppliers by country/region
Company Type
Properties
- Melting point:
- 102-106 °C (lit.)
- Boiling point:
- 192-193 °C (lit.)
- Density
- 1,37 g/cm3
- vapor pressure
- 5 hPa (25 °C)
- refractive index
- 1.4062 (estimate)
- Flash point:
- 192-193°C
- storage temp.
- Store below +30°C.
- solubility
- 1.6g/l
- form
- Liquid
- color
- Clear colorless to faintly yellow
- PH
- 4.0-6.0 (10g/l, H2O, 20℃)suspension
- Water Solubility
- Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
- Merck
- 14,4287
- BRN
- 774590
- Stability:
- Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
Safety Information
- Symbol(GHS)
GHS07,GHS09
- Signal word
- Warning
- Hazard statements
- H312-H315-H317-H335-H411
- Precautionary statements
- P261-P264-P271-P273-P280-P302+P352+P312
- Hazard Codes
- Xn
- Risk Statements
- 21-38-41-43-36/37/38-36/38
- Safety Statements
- 26-36/37/39-36/37
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 1
- RTECS
- EM6125000
- TSCA
- Yes
- HS Code
- 29171990
- Toxicity
- LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg
Use
Dimethyl fumarate is the methyl ester of fumaric acid. Dimethyl fumarate, marketed in Germany under the trade name of Fumaderm, is used for oral therapy of psoriasis in combination with other drugs. Later it has been used to treat adults with relapsing multiple sclerosis[a chronic inflammatory, demyelinating and neurodegenerative disease of the CNS resulting in neurological disability] since 2013(trade name Tecfidera). Dimethyl fumarate is thought to have immunomodulatory properties without significant immunosuppression. In preclinical studies, dimethyl fumarate exhibited anti-inflammatory and cytoprotective properties that are generally thought to be mediated via activation of the nuclear factor [erythroid-derived 2]-like 2 transcriptional pathway, which is involved in the cellular response to oxidative stress.
76 India supplier list of "Dimethyl fumarate"
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:DIMETHYL FUMARATE
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl Fumarate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl Fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Dimethyl fumarate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA