Aminopyrine
- CAS No.
- 58-15-1
- Chemical Name:
- Aminopyrine
- Synonyms
- AMINOPYRINE;AMINOPHENAZONE;AMIDOPYRINE;4-DIMETHYLAMINOANTIPYRINE;dimethylaminophenazone;Piramidon;Aminopyrazolin;Dimethylaminoantipyrine;4-DiMethylaMino-1,5-diMethyl-2-phenyl-1-pyrazolone;2-dihydro-4-(N.,N-dimethylamino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
- CBNumber:
- CB1476086
- Molecular Formula:
- C13H17N3O
- Molecular Weight:
- 231.29
- MOL File:
- 58-15-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/26 17:21:34
| Melting point | 107-109 °C(lit.) |
|---|---|
| Boiling point | 373.38°C (rough estimate) |
| Density | 1.0744 (rough estimate) |
| refractive index | 1.6140 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | Crystalline Powder, Crystals and/or Chunks |
| pka | pKa 5.0 (Uncertain) |
| color | Off-white to brownish |
| Water Solubility | 5.55 g/100 mL |
| Sensitive | Air & Light Sensitive |
| Merck | 14,474 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water. |
| InChIKey | RMMXTBMQSGEXHJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 58-15-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Aminopyrine(58-15-1) |
| EPA Substance Registry System | Aminopyrine (58-15-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CD2625000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29331190 | |||||||||
| Toxicity | LD50 orally in rats: 1.7 g/kg (Hart) | |||||||||
| NFPA 704 |
|
Aminopyrine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D8015 | 4-Dimethylaminoantipyrine reactive nitrogen species scavenger | 58-15-1 | 25G | ₹9526 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D8015 | 4-Dimethylaminoantipyrine reactive nitrogen species scavenger | 58-15-1 | 100G | ₹27852.73 | 2022-06-14 | Buy |
| ALFA India | ALF-B21436-30 | 4-(Dimethylamino)antipyrine, 98+% | 58-15-1 | 250g | ₹19133 | 2022-05-26 | Buy |
| ALFA India | ALF-B21436-18 | 4-(Dimethylamino)antipyrine, 98+% | 58-15-1 | 50g | ₹3928 | 2022-05-26 | Buy |
| ALFA India | ALF-B21436-0B | 4-(Dimethylamino)antipyrine, 98+% | 58-15-1 | 1000g | ₹59039 | 2022-05-26 | Buy |
Aminopyrine Chemical Properties,Uses,Production
Chemical Properties
White leaf-like crystals or crystalline powder. Odorless, slightly bitter taste. It is stable in the air, but will deteriorate in sunlight. When there is moisture, it is easy to chemically react with weak oxidants. Soluble in alcohol, chloroform, benzene and ether, soluble in water. The solubility in water increases with the addition of sodium benzoate. Aqueous solutions are weakly alkaline to litmus. The melting point is 107-109°C.
Uses
Aminopyrine is used as an antipyretic and analgesic drug. It belongs to the pyrazolone derivatives having a most toxic and most dangerous analgesic effect and it is a non-narcotic drug. Due to strong adverse effects, its single medicine preparation is gradually replaced by compound preparation.
Definition
ChEBI: Aminopyrine is a pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an environmental contaminant and a xenobiotic. It is a tertiary amino compound and a pyrazolone.
Preparation
Aminopyrine is synthesized from 4-Aminoantipyrine by catalytic hydrogenation (alkylation). Water is firstly added to the dissolving tank, heated to 50-60°C, put into 4-Aminoantipyrine under stirring, and poured into the hydrogenation tank after complete dissolving. Wash the dissolving tank with water, mix it with the nickel catalyst, and then add it to the hydrogenation tank. The hydrogenation tank was evacuated, then the vacuum valve was closed, hydrogen was introduced, and stirring was started. When the pressure rose to 0.245MPa, the hydrogen was stopped. Add formaldehyde and continue to feed hydrogen. The speed of adding formaldehyde is based on the standard of 1.8-2 cubic meters of hydrogen absorption per 5L of formaldehyde, and the reaction temperature is controlled at 60-85°C. After passing the test, filter by pressure, cool the filtrate to below 25°C, and separate out crystals, which are then filtered to obtain the crude aminopyrine. The crude aminopyrine, ethanol, and activated carbon were heated to 75-80°C, stirred for 1 hour, and filtered under pressure. The filtrate was cooled to 10°C, crystals were precipitated, filtered, washed with ethanol, and air-dried to obtain aminopyrine.
World Health Organization (WHO)
Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)
General Description
Small colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
Aminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.
Fire Hazard
Flash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.
Safety Profile
Human poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
It crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]
Aminopyrine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Ultra Pure Lab Chem Industries LLP | 08046077962 | Mumbai, India | 252 | 58 | Inquiry |
| A. B. Enterprises | +91-8048077585 | Mumbai, India | 1396 | 58 | Inquiry |