Sodium metabisulfite
- CAS No.
- 7681-57-4
- Chemical Name:
- Sodium metabisulfite
- Synonyms
- Sodium pyrosulfite;Metabisulfite Sodium;Sodium pyrosulphite;Sodium disulphite;E223;Sodiummetabisufite;Disodium disulphite;fertisilo;Sodium metabisuL;SodiuM pyrosulfit
- CBNumber:
- CB9854280
- Molecular Formula:
- H2O5S2.2Na
- Molecular Weight:
- 192.12
- MOL File:
- 7681-57-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/21 15:02:05
| Melting point | >300 °C (lit.) |
|---|---|
| Density | 1.48 |
| storage temp. | Store at +5°C to +30°C. |
| solubility | 540 g/L (20°C) |
| form | Powder/Solid |
| Specific Gravity | 1.48 |
| color | White to slightly yellow |
| Odor | Sulphorous |
| PH Range | 4.5 at 50 g/l at 20 °C |
| PH | 3.5-5 (50g/l, H2O, 20℃) |
| Water Solubility | 540 g/L (20 ºC) |
| Sensitive | Air & Moisture Sensitive |
| Merck | 14,8638 |
| Exposure limits |
ACGIH: TWA 5 mg/m3 NIOSH: TWA 5 mg/m3 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. Contact with strong acids releases a poisonous gas. May be moisture and air sensitive. |
| InChIKey | HRZFUMHJMZEROT-UHFFFAOYSA-L |
| CAS DataBase Reference | 7681-57-4(CAS DataBase Reference) |
| EPA Substance Registry System | Sodium metabisulfite (7681-57-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-31-41-36/37/38-52 | |||||||||
| Safety Statements | 26-39-46-36-16 | |||||||||
| RIDADR | 3260 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | UX8225000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2832 10 00 | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 orally in Rabbit: 1540 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Sodium metabisulfite price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9000 | Sodium metabisulfite ReagentPlus?, ≥99% | 7681-57-4 | 500G | ₹3496.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9000 | Sodium metabisulfite ReagentPlus?, ≥99% | 7681-57-4 | 1KG | ₹4568.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9000 | Sodium metabisulfite ReagentPlus?, ≥99% | 7681-57-4 | 5KG | ₹6116.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 799343 | Sodium metabisulfite anhydrous, free-flowing, Redi-Dri?, ReagentPlus?, ≥99% | 7681-57-4 | 500G | ₹2630.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 799343 | Sodium metabisulfite anhydrous, free-flowing, Redi-Dri?, ReagentPlus?, ≥99% | 7681-57-4 | 1KG | ₹3323.28 | 2022-06-14 | Buy |
Sodium metabisulfite Chemical Properties,Uses,Production
Chemical Properties
Sodium metabisulfite is a white crystalline powder. Sulfur dioxide odor. It may be considered the anhydride of 2 molecules of sodium disulfite.
Uses
sodium metabisulfite is an anti-oxidant and reducing agent.
Production Methods
Sodium metabisulfite is prepared by saturating a solution of sodium hydroxide with sulfur dioxide and allowing crystallization to occur; hydrogen is passed through the solution to exclude air. Sodium metabisulfite may also be prepared by saturating a solution of sodium carbonate with sulfur dioxide and allowing crystallization to occur, or by thermally dehydrating sodium bisulfite.
Definition
ChEBI: An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.
General Description
Sodium metabisulfite (MBS, Sodium disulfite) is an inorganic salt. It is the sodium salt of disulphurous (pyrosulfurous) acid. It is widely used in textile dyeing, photography and paper industry. It is also commonly added to various food products and wines as a preservative.
Hazard
Toxic by inhalation. Upper respiratory tract irritant. Questionable carcinogen.
Health Hazard
Sodium metabisulfite may cause bronchospasm, oculonasal symptoms, and urticaria in sulfite-sensitive individuals; irritation of mucous membranes may occur from inhalation of the dust.
Pharmaceutical Applications
Sodium metabisulfite is used as an antioxidant in oral, parenteral,
and topical pharmaceutical formulations, at concentrations of
0.01–1.0% w/v, and at a concentration of approximately 27% w/v
in intramuscular injection preparations. Primarily, sodium metabisulfite
is used in acidic preparations; for alkaline preparations,
sodium sulfite is usually preferred. Sodium
metabisulfite also has some antimicrobial activity, which is greatest
at acid pH, and may be used as a preservative in oral preparations
such as syrups.
In the food industry and in wine production, sodium metabisulfite
is similarly used as an antioxidant, antimicrobial preservative,
and antibrowning agent. However, at concentrations above
about 550 ppm it imparts a noticeable flavor to preparations.
Sodium metabisulfite usually contains small amounts of sodium
sulfite and sodium sulfate.
Contact allergens
This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.
Safety Profile
An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.
Safety
Sodium metabisulfite is widely used as an antioxidant in oral,
topical, and parenteral pharmaceutical formulations; it is also
widely used in food products.
Although it is extensively used in a variety of preparations,
sodium metabisulfite and other sulfites have been associated with a
number of severe to fatal adverse reactions. These are usually
hypersensitivity-type reactions and include bronchospasm and
anaphylaxis. Allergy to sulfite antioxidants is estimated to occur
in 5–10% of asthmatics, although adverse reactions may also occur
in nonasthmatics with no history of allergy.
Following oral ingestion, sodium metabisulfite is oxidized to
sulfate and is excreted in urine. Ingestion may result in gastric
irritation, owing to the liberation of sulfurous acid, while ingestion
of large amounts of sodium metabisulfite can cause colic, diarrhea,
circulatory disturbances, CNS depression, and death.
In Europe, the acceptable daily intake of sodium metabisulfite
and other sulfites used in foodstuffs has been set at up to 3.5 mg/kg
body-weight, calculated as sulfur dioxide (SO2). The WHO has
similarly also set an acceptable daily intake of sodium metabisulfite,
and other sulfites, at up to 7.0 mg/kg body-weight, calculated as
sulfur dioxide (SO2).
LD50 (rat, IV): 0.12 g/kg
Potential Exposure
Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.
Carcinogenicity
Sodium metabisulfite was genotoxic in mice in vivo as determined by chromosomal aberration, micronucleus, and sperm shape assays. It was not mutagenic in bacterial assays.
storage
On exposure to air and moisture, sodium metabisulfite is slowly
oxidized to sodium sulfate with disintegration of the crystals.
Addition of strong acids to the solid liberates sulfur dioxide.
In water, sodium metabisulfite is immediately converted to
sodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodium
metabisulfite solutions also decompose in air, especially on heating.
Solutions that are to be sterilized by autoclaving should be filled into
containers in which the air has been replaced with an inert gas, such
as nitrogen. The addition of dextrose to aqueous sodium
metabisulfite solutions results in a decrease in the stability of the
metabisulfite.
The bulk material should be stored in a well-closed container,
protected from light, in a cool, dry place.
Shipping
UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
Incompatibilities
Sodium metabisulfite reacts with sympathomimetics and other
drugs that are ortho- or para-hydroxybenzyl alcohol derivatives to
form sulfonic acid derivatives possessing little or no pharmacological
activity. The most important drugs subject to this inactivation
are epinephrine (adrenaline) and its derivatives. In addition,
sodium metabisulfite is incompatible with chloramphenicol owing
to a more complex reaction; it also inactivates cisplatin in
solution.
It is incompatible with phenylmercuric acetate when autoclaved
in eye drop preparations.
Sodium metabisulfite may react with the rubber caps of
multidose vials, which should therefore be pretreated with sodium
metabisulfite solution.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (epidural;inhalation; IM and IV injections; ophthalmic solutions; oral preparations; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium metabisulfite Preparation Products And Raw materials
Raw materials
Preparation Products
1of8
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Annexe Chem Pvt Ltd | +91-9724624061 +91-9898722162 | Gujarat, India | 57 | 58 | Inquiry |
| Varun Enterprises | +91-8700598846 +91-9811508889 | New Delhi, India | 4 | 58 | Inquiry |
| Ghanshyam Chemicals | +91-7210130135 +91-9824087558 | Gujarat, India | 20 | 58 | Inquiry |
| Sujata Chemicals | +91-9898025496 +91-9898025496 | Gujarat, India | 73 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Shree Sulphurics Pvt Ltd (SSPL) | +91-2224915709 +91-9833300322 | Mumbai, India | 30 | 58 | Inquiry |
| Snow White Products | +91-9820070100 +91-9820070100 | Maharashtra, India | 35 | 58 | Inquiry |
| Jay Dinesh Chemicals | +91-9974013523 +91-9909949962 | Gujarat, India | 6 | 58 | Inquiry |
| Pd Navkar Bio Chem Pvt Ltd | +91-8022157444 +91-8022157444 | Karnataka, India | 49 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| HRV Global Life Sciences | 58 |
| Annexe Chem Pvt Ltd | 58 |
| Varun Enterprises | 58 |
| Ghanshyam Chemicals | 58 |
| Sujata Chemicals | 58 |
| Merck Ltd | 58 |
| Shree Sulphurics Pvt Ltd (SSPL) | 58 |
| Snow White Products | 58 |
| Jay Dinesh Chemicals | 58 |
| Pd Navkar Bio Chem Pvt Ltd | 58 |
Related articles
- The Multifaceted Role of Sodium Metabisulfite in Modern Chemistry
- Sodium metabisulfite, a chemical compound with the formula Na2S2O5, serves as a versatile agent widely utilized in various ind....
- May 29，2024
- Sodium Metabisulfite: Uses, Synthesis and Hazards
- The passage introduces the uses, synthesis and hazards of sodium metabisulfite, also mention the reaction with water of it.
- Nov 24，2022
- a challenging allergen：sodium metabisulfite
- Sodium metabisulfite appears as a white crystalline or powder solid with a slight sulfur odor. Toxic by inhalation. Sodium dis....
- Apr 11，2022
7681-57-4(Sodium metabisulfite)Related Search:
1of4
chevron_right