Ethylenediaminetetraacetic acid disodium salt
- CAS No.
- 139-33-3
- Chemical Name:
- Ethylenediaminetetraacetic acid disodium salt
- Synonyms
- EDTA-2NA;DISODIUM EDTA;DISODIUM EDETATE;ETA;EDETATE DISODIUM;EDTA DISODIUM;EDTA DISODIUM SALT;TITRIPLEX III;DISODIUM ETHYLENEDIAMINETETRAACETATE;EDTA NA2
- CBNumber:
- CB8371263
- Molecular Formula:
- C10H14N2Na2O8
- Molecular Weight:
- 336.21
- MOL File:
- 139-33-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/25 11:16:06
| Melting point | 248 °C (dec.)(lit.) |
|---|---|
| Boiling point | >100 °C |
| Density | 1.01 g/mL at 25 °C |
| vapor pressure | 0Pa at 25℃ |
| refractive index | n20/D 1.363 |
| storage temp. | 2-8°C |
| solubility | H2O: clear, colorless |
| form | solution |
| color | ≤5 (0.5 M)(APHA) |
| PH | 8.0±0.2 |
| Odor | at 100.00?%. odorless |
| Water Solubility | Miscible with water. |
| BRN | 3822669 |
| Stability | Hygroscopic |
| LogP | -4.3 at 25℃ |
| CAS DataBase Reference | 139-33-3(CAS DataBase Reference) |
| EPA Substance Registry System | Ethylenediaminetetraacetic acid disodium salt (139-33-3) |
| Absorption | cut-off at 268nm |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H303-H332-H372-H412 | |||||||||
| Precautionary statements | P260-P271-P273-P304+P340+P312-P312-P501 | |||||||||
| Hazard Codes | Xn,C | |||||||||
| Risk Statements | 36/38-36/37/38-22-34-21/22 | |||||||||
| Safety Statements | 26-36-37/39-45-36/37/39-36/37 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AH4410000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29224999 | |||||||||
| Hazardous Substances Data | 139-33-3(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,260mg/kg (260mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 126S, 1956. | |||||||||
| NFPA 704 |
|
Ethylenediaminetetraacetic acid disodium salt price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E7889 | Ethylenediaminetetraacetic acid disodium salt solution for molecular biology, 0.5?M in H2O, DNase, RNase, NICKase and protease, none detected | 139-33-3 | 100ML | ₹6733.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E7889 | Ethylenediaminetetraacetic acid disodium salt solution for molecular biology, 0.5?M in H2O, DNase, RNase, NICKase and protease, none detected | 139-33-3 | 1L | ₹26932.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 2854 | Ethylenediaminetetraacetic acid disodium salt solution 2%, solution | 139-33-3 | 15ML | ₹5834.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 03690 | Ethylenediaminetetraacetic acid disodium salt solution BioUltra, for molecular biology, pH 8.0, ~0.5?M in H2O | 139-33-3 | 100ML | ₹5390.85 | 2022-06-14 | Buy |
Ethylenediaminetetraacetic acid disodium salt Chemical Properties,Uses,Production
Chemical Properties
Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.
Uses
Ethylenediaminetetraacetic acid disodium salt is widely used in textile industry. Usually applied to dissolve limescale. It is applied in textile industry, pulp and paper industry and also in chelation therapy. In cosmetics, it acts as a sequestering agent. It acts as a corrosion inhibitor to carbon steel in the industries. It also acts as a food additive.
Application
Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten. It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Production Methods
Disodium edetate may be prepared by the reaction of edetic acid and sodium hydroxide.
Definition
ChEBI: An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).
General Description
Ethylenediamine tetraacetate (EDTA) is a calcium ion chelator, that has a low molecular mass of 292.24 Da.
Pharmaceutical Applications
Disodium edetate is used as a chelating agent in a wide range of
pharmaceutical preparations, including mouthwashes, ophthalmic
preparations, and topical preparations, typically at concentrations
between 0.005 and 0.1% w/v.
Disodium edetate forms stable water-soluble complexes (chelates)
with alkaline earth and heavy-metal ions. The chelated form
has few of the properties of the free ion, and for this reason
chelating agents are often described as ‘removing’ ions from
solution, a process known as sequestering. The stability of the
metal–edetate complex is dependent on the metal ion involved and
the pH.
Disodium edetate is also used as a water softener as it will chelate
calcium and magnesium ions present in hard water. It is also used
therapeutically as an anticoagulant as it will chelate calcium and
prevent the coagulation of blood in vitro. Concentrations of 0.1%
w/v are used in small volumes for hematological testing and 0.3%
w/v in transfusions.
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and NasO.
storage
Edetate salts are more stable than edetic acid (see also Edetic acid).
However, disodium edetate dihydrate loses water of crystallization
when heated to 120°C. Aqueous solutions of disodium edetate may
be sterilized by autoclaving, and should be stored in an alkali-free
container.
Disodium edetate is hygroscopic and is unstable when exposed
to moisture. It should be stored in a well-closed container in a cool,
dry place.
Incompatibilities
Disodium edetate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic preparations; oral capsules, solutions, suspensions, syrups, and tablets; rectal topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Ethylenediaminetetraacetic acid disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Indiana ChemPort | +91-91-2652638667 +91-7574886711 | Gujarat, India | 85 | 58 | Inquiry |
| Yogi Dye Chem Industries | +91-9821098577 +91-9821098577 | Mumbai, India | 124 | 58 | Inquiry |
| S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
| VITRAG CHEMICALS PVT LTD | +91-7490053194 +91-7490053194 | Gujarat, India | 47 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| AVA CHEMICALS PVT LTD | +91-8879390046 +91-8879390046 | Maharashtra, India | 74 | 58 | Inquiry |
| Kronox Lab Sciences Pvt Ltd | +91-9313231074 +91-9313231074 | Gujarat, India | 240 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Annexe Chem Pvt Ltd | +91-9724624061 +91-9898722162 | Gujarat, India | 57 | 58 | Inquiry |
| Satyajit Chemicals Pvt Ltd | +91-2227801134 +91-9930081962 | Maharashtra, India | 10 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Indiana ChemPort | 58 |
| Yogi Dye Chem Industries | 58 |
| S.V ENTERPRISES | 58 |
| VITRAG CHEMICALS PVT LTD | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| AVA CHEMICALS PVT LTD | 58 |
| Kronox Lab Sciences Pvt Ltd | 58 |
| HRV Global Life Sciences | 58 |
| Annexe Chem Pvt Ltd | 58 |
| Satyajit Chemicals Pvt Ltd | 58 |
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