Acetazolamide
- CAS No.
- 59-66-5
- Chemical Name:
- Acetazolamide
- Synonyms
- 6063;Diamox;Acetazolamid;Acetazolamide for system suitability CRS;N-(5-SULFAMOYL-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;N-(5-[AMINOSULFONYL]-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;Didoc;Donmox;Edemox;Glupax
- CBNumber:
- CB0430959
- Molecular Formula:
- C4H6N4O3S2
- Molecular Weight:
- 222.25
- MOL File:
- 59-66-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/16 16:12:12
| Melting point | 258-259 °C |
|---|---|
| Density | 1.610 (estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol. |
| pka | 7.2(at 25℃) |
| form | solid |
| color | White to Off-White |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| λmax | 265nm(H2O)(lit.) |
| Merck | 14,53 |
| BRN | 212994 |
| BCS Class | 4 |
| Stability | Hygroscopic |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
| CAS DataBase Reference | 59-66-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide(59-66-5) |
| EPA Substance Registry System | Acetazolamide (59-66-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AC8225000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 oral in mouse: 4300mg/kg | |||||||||
| NFPA 704 |
|
Acetazolamide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A6011 | Acetazolamide ≥99%, powder | 59-66-5 | 10G | ₹5758.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6011 | Acetazolamide ≥99%, powder | 59-66-5 | 25G | ₹10987.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6011 | Acetazolamide ≥99%, powder | 59-66-5 | 100G | ₹24312.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1908 | Acetazolamide Pharmaceutical Secondary Standard; Certified Reference Material | 59-66-5 | 5G | ₹31652.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6011 | Acetazolamide ≥99%, powder | 59-66-5 | 250G | ₹47792.38 | 2022-06-14 | Buy |
Acetazolamide Chemical Properties,Uses,Production
Description
Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness.
Chemical Properties
White Solid
Uses
Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs.
General Description
White to yellowish-white fine crystalline powder. No odor or taste.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A weak acid and a diazo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Fire Hazard
Flash point data for Acetazolamide are not available; however, Acetazolamide is probably combustible.
Mechanism of action
Acetazolamide is an aromatic sulfonamide used as a carbonic anhydrase inhibitor. It facilitates production of alkaline urine with an elevated biocarbonate, sodium, and potassium ion concentrations. By inhibiting carbonic anhydrase, the drug suppresses reabsorption of sodium ions in exchange for hydrogen ions, increases reflux of bicarbonate and sodium ions and reduces reflux of chloride ions. During this process, chloride ions are kept in the kidneys to cover of insufficiency of bicarbonate ions, and for keeping an ion balance. Electrolytic contents of fluid secreted by the kidneys in patients taking carbonic anhydrase inhibitors are characterized by elevated levels of sodium, potassium, and bicarbonate ions and a moderate increase in water level. Urine becomes basic, and the concentration of bicarbonate in the plasma is reduced.
Clinical Use
Acetazolamide was the first of the carbonic anhydrase inhibitors to be introduced as an orally effective diuretic, with a diuretic effect that lasts approximately 8 to 12 hours. As mentioned earlier, its diuretic action is limited because of the systemic acidosis it produces. Acetazolamide reduces the rate of aqueous humor formation and is used primarily for reducing intraocular pressure in the treatment of glaucoma. The dose is 250 mg to 1 g per day.
Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: dyspnea. An experimental teratogen by many routes. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, and SOx,. A carbonic anhydrase inhibitor and dmretic used to treat glaucoma.
Purification Methods
It is recrystallised from water. [Roblin & Clapp J Am Chem Soc 72 4890 1950, Beilstein 27 III/IV 8219.]
Acetazolamide Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
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| Nakoda Chemicals Ltd | +91-9848218200 +91-9848218200 | Telangana, India | 15 | 58 | Inquiry |
| KPS Chemicals And Pharmaceuticals | +91-9870076629 +91-8469484608 | Gujarat, India | 33 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Meruvax Pharma (South Asia) | +91 917-735-9925 | Andhra Pradesh, India | 106 | 58 | Inquiry |
| CTX Lifesciences Private Limited | +91 22 3209 2669 | Mumbai, India | 9 | 58 | Inquiry |
| Nest Life Science Pvt., Ltd. | 91-79-26586039 | Gujarat, India | 26 | 58 | Inquiry |
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