N-Acetylsulfanilyl chloride
- CAS No.
- 121-60-8
- Chemical Name:
- N-Acetylsulfanilyl chloride
- Synonyms
- ASC;4-ACETAMIDOBENZENESULFONYL CHLORIDE;NASC;Acetylsulfanilyl chloride;CARD5;NSC 127860;dagenanchloride;acetylsulfanilyl;Dagenan chloride;N-Acetylsulfanilyl
- CBNumber:
- CB4452614
- Molecular Formula:
- C8H8ClNO3S
- Molecular Weight:
- 233.67
- MOL File:
- 121-60-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/4 19:18:49
| Melting point | 142-145 °C (dec.)(lit.) |
|---|---|
| Boiling point | 426.8±28.0 °C(Predicted) |
| Density | 1.2977 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6300 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 13.75±0.70(Predicted) |
| form | Granular Crystalline Powder or Crystals |
| color | White to cream-beige |
| Water Solubility | SLIGHTLY SOLUBLE |
| Sensitive | Moisture Sensitive |
| Merck | 14,103 |
| BRN | 746676 |
| LogP | 2.05 at 25℃ |
| CAS DataBase Reference | 121-60-8(CAS DataBase Reference) |
| NIST Chemistry Reference | P-acetamidobenzene sulfonyl chloride(121-60-8) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 4-(acetylamino)- (121-60-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H335 | |||||||||
| Precautionary statements | P260-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 22-34-37 | |||||||||
| Safety Statements | 26-36/37/39-45-28B | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DB8837500 | |||||||||
| F | 9-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29242995 | |||||||||
| Toxicity | LD50 oral in rat: > 3200mg/kg | |||||||||
| NFPA 704 |
|
N-Acetylsulfanilyl chloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 112747 | N-Acetylsulfanilyl chloride 98% | 121-60-8 | 100G | ₹1894.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112747 | N-Acetylsulfanilyl chloride 98% | 121-60-8 | 1KG | ₹10825 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0074 | 4-Acetamidobenzenesulfonyl Chloride | 121-60-8 | 25G | ₹8600 | 2022-05-26 | Buy |
N-Acetylsulfanilyl chloride Chemical Properties,Uses,Production
Chemical Properties
OFF-WHITE TO SLIGHTLY GREY GRANULAR CRYST. POWDER
Uses
N-Acetylsulfanilyl chloride is used?in the preparation of sulfanilamide and its derivatives which are intermediates to produce sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. It is also used as a Pharma raw material. N-Acetylsulfanilyl chloride widely used in the fields of dye, medicine, mainly used for preparation of Sulfanilamide, Sulfanilylureal, Sulfatolamide, Sulphathiourea , Sulfaguanidine and Sulfacetamide and etc.
Production Methods
Acetanilide is introduced into stirred chlorosulfuric acid solution at 20 ℃. The solution is then heated to 55 ℃ and kept at this temperature for 1.5 h. The solution is cooled to 20 ℃ and introduced as a thin jet into water, the temperature of which is kept at 0 – 5 ℃ by external cooling. The precipitated sulfochloride is filtered and washed with cold water until neutral to Congo Red. Yield is 80 – 82%. The crude product contains about 60% water; the dried product melts at 144 – 147 ℃. About 1 – 2% of bis(acetylaminophenyl) sulfone is obtained as a byproduct. If thionyl chloride is added, less chlorosulfuric acid is needed because it can be replaced partly byoleum. The product is stable for several days if kept in a cool place. It is generally used directly in the moist state. 4-(Acetylamino)benzenesulfonyl chloride is an important intermediate in the manufacture of sulfonamides and in the synthesis of parabase ester.
General Description
L-hydroxyproline has been derivatized with N-acetylsulfanilyl chloride and 5-chlorovaleric acid during the synthesis of the haptens HP1 and HP2.
Safety Profile
A poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic vapors of NOx, SOx, and Cl.
Purification Methods
Crystallise the chloride from toluene, CHCl3, or ethylene dichloride. [Beilstein 14 IV 2703.]
N-Acetylsulfanilyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Innovative Labs | +91-9885794886 +91-9885794886 | Telangana, India | 219 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Sirius Pharmaceuticals Pvt. Ltd. | 91-22-66921445 | Maharashtra, India | 38 | 58 | Inquiry |
| Sris Pharmaceuticals | 91-9989522441 | Telangana, India | 130 | 58 | Inquiry |
| Venshiv Pharmachem Private Limited | 09490747165 | Hyderabad, India | 2 | 58 | Inquiry |
| Porus Laboratories (P) Ltd. | 91-40-40118098 | Hyderabad, India | 16 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Innovative Labs | 91--9885794886 | Mallapur, India | 111 | 58 | Inquiry |
| Medkem Laboratories | 91-40-23700606 | Andhra Pradesh, India | 297 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Innovative Labs | 58 |
| Reax Chemicals | 58 |
| Sirius Pharmaceuticals Pvt. Ltd. | 58 |
| Sris Pharmaceuticals | 58 |
| Venshiv Pharmachem Private Limited | 58 |
| Porus Laboratories (P) Ltd. | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| HiMedia Laboratories | 58 |
| Innovative Labs | 58 |
| Medkem Laboratories | 58 |
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