4-(아세틸아미노)벤젠설포닐 클로라이드
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4-(아세틸아미노)벤젠설포닐 클로라이드 속성
- 녹는점
- 142-145 °C (dec.)(lit.)
- 끓는 점
- 426.8±28.0 °C(Predicted)
- 밀도
- 1.2977 (rough estimate)
- 증기압
- 0Pa at 25℃
- 굴절률
- 1.6300 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- 산도 계수 (pKa)
- 13.75±0.70(Predicted)
- 물리적 상태
- 입상 결정질 분말 또는 결정
- 색상
- 흰색~크림베이지
- 수용성
- 약간 용해됨
- 감도
- Moisture Sensitive
- Merck
- 14,103
- BRN
- 746676
- LogP
- 2.05 at 25℃
- CAS 데이터베이스
- 121-60-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C | ||
---|---|---|---|
위험 카페고리 넘버 | 22-34-37 | ||
안전지침서 | 26-36/37/39-45-28B | ||
유엔번호(UN No.) | UN 3261 8/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DB8837500 | ||
F 고인화성물질 | 9-21 | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | II | ||
HS 번호 | 29242995 | ||
유해 물질 데이터 | 121-60-8(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: > 3200mg/kg | ||
기존화학 물질 | KE-00083 |
4-(아세틸아미노)벤젠설포닐 클로라이드 C화학적 특성, 용도, 생산
화학적 성질
OFF-WHITE TO SLIGHTLY GREY GRANULAR CRYST. POWDER용도
N-Acetylsulfanilyl chloride is used?in the preparation of sulfanilamide and its derivatives which are intermediates to produce sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. It is also used as a Pharma raw material. N-Acetylsulfanilyl chloride widely used in the fields of dye, medicine, mainly used for preparation of Sulfanilamide, Sulfanilylureal, Sulfatolamide, Sulphathiourea , Sulfaguanidine and Sulfacetamide and etc.생산 방법
Acetanilide is introduced into stirred chlorosulfuric acid solution at 20 ℃. The solution is then heated to 55 ℃ and kept at this temperature for 1.5 h. The solution is cooled to 20 ℃ and introduced as a thin jet into water, the temperature of which is kept at 0 – 5 ℃ by external cooling. The precipitated sulfochloride is filtered and washed with cold water until neutral to Congo Red. Yield is 80 – 82%. The crude product contains about 60% water; the dried product melts at 144 – 147 ℃. About 1 – 2% of bis(acetylaminophenyl) sulfone is obtained as a byproduct. If thionyl chloride is added, less chlorosulfuric acid is needed because it can be replaced partly byoleum. The product is stable for several days if kept in a cool place. It is generally used directly in the moist state. 4-(Acetylamino)benzenesulfonyl chloride is an important intermediate in the manufacture of sulfonamides and in the synthesis of parabase ester.일반 설명
L-hydroxyproline has been derivatized with N-acetylsulfanilyl chloride and 5-chlorovaleric acid during the synthesis of the haptens HP1 and HP2.Safety Profile
A poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic vapors of NOx, SOx, and Cl.Purification Methods
Crystallise the chloride from toluene, CHCl3, or ethylene dichloride. [Beilstein 14 IV 2703.]4-(아세틸아미노)벤젠설포닐 클로라이드 준비 용품 및 원자재
원자재
준비 용품
4-(MORPHOLINE-4-SULFONYL)-PHENYLAMINE
fluorescent brightener 311
설파닐아미드
술파메톡사졸
(1R,2R)-N-BOC-1-AMINO-2-페닐사이클로프로판카복실산
P-ACETAMIDOBENZENESULFINIC ACID
설파살라진
4-아미노-N-에틸-벤젠술폰아미드
4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT
설파피라졸
P-톨일 다이설파이드
설파렌
4-아세타미도벤젠설포나닐리드
4'-(4-MethylphenylsulfaMoyl)acetanilide, 97%
4'-(2-MethoxyphenylsulfaMoyl)acetanilide, 97%
4-(아세틸아미노)벤젠설포닐 클로라이드 공급 업체
글로벌( 391)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12460 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20320 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16209 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |