설파닐아미드

설파닐아미드 속성

설파닐아미드 MSDS

Sulfanilamide

설파닐아미드 C화학적 특성, 용도, 생산

용도

현대에서는 항생제가 이 화합물을 대체하여 사용량이 줄어들었고 현재는 질의 칸디다증 치료에 사용된다. 궤장성 대장염 혹은 류마티즈성 관절염에도 사용된다.

제품 소개

엽산 생산에 필요한 파라 아미노 벤조산(PABA)과 유사한 구조를 띄어 PABA 대신 엽산 생산에 관여하게 되어 미생물의 엽산 생합성을 막는다. 숙주의 세포는 엽산을 자체 생산하지 않기에 해당 물질에 영향을 받지 않는다.

개요

Sulfanilamide is an organic sulfur compound structurally similar to p-aminobenzoic acid (PABA) with antibacterial property. Sulfanilamide competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

화학적 성질

White granules or powder crystals, odorless. Taste slightly bitter. Slightly soluble in cold water, ethanol, methanol, ether and acetone, easily soluble in boiling water, glycerin, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene and petroleum ether.

용도

Sulfanilamide is an antibacterial agent and antimicrobial agent of sulfonamide type (topical and vaginal).

정의

ChEBI: Sulfanilamide is a sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, an antibacterial agent and a drug allergen. It is a substituted aniline, a sulfonamide antibiotic and a sulfonamide.

제조 방법

Sulfonamide is synthesized from acetanilide by chlorosulfonation, amination, hydrolysis, and neutralization:
Acetanilide is reacted with chlorosulfonic acid at 40～50℃, then cooled, slowly added to water for acid decomposition, precipitated at the same time, dried and filtered to obtain p-acetamidobenzenesulfonyl chloride, and then subjected to ammoniation, and the amination temperature is controlled at 40～ 45 ℃, and then hydrolyzed, acidified to obtain sulfonamide.

World Health Organization (WHO)

Sulfanilamide, a sulfonamide anti-infective agent, was introduced in 1936 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfanilamide is still used in some countries as a pessaries or as vaginal cream.

일반 설명

White powder. pH of 0.5% aqueous solution: 5.8-6.1.

공기와 물의 반응

May be unstable if exposed for long periods air and light . Slightly water soluble.

반응 프로필

Sulfanilamide is an amino acid. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May react with azo and diazo compounds to generate toxic gases.

화재위험

Flash point data for Sulfanilamide are not available but Sulfanilamide is probably combustible.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intravenous routes. Human teratogenic effects by unspecified route: developmental abnormalities of the blood and lymphatic systems (including the spleen and bone marrow). Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NOx and SOx.

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설파닐아미드 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	193	58
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	Jerry@xhobio.com	China	882	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18152	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	232	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58

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