p-아미노안식향산에틸에스테르
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p-아미노안식향산에틸에스테르 속성
- 녹는점
- 88-90 °C
- 끓는 점
- 172 °C (12.7517 mmHg)
- 밀도
- 1.17
- 굴절률
- 1.5600 (estimate)
- 인화점
- 172°C/13mm
- 저장 조건
- 2-8°C
- 용해도
- 알코올: 5ml에 용해성 1g
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 2.5(at 25℃)
- 색상
- 하얀색
- 냄새
- 냄새 없는
- 수용성
- 에탄올, 클로로포름, 에틸 에테르 및 묽은 산에 용해됩니다. 물에 거의 녹지 않음
- Merck
- 14,1086
- BRN
- 638434
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- BLFLLBZGZJTVJG-UHFFFAOYSA-N
- LogP
- 1.860
- CAS 데이터베이스
- 94-09-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 43-36/37/38-39/23/24/25-23/24/25-11 | ||
안전지침서 | 22-24/25-37/39-26-24-45-36/37-16-7 | ||
유엔번호(UN No.) | 3077 | ||
WGK 독일 | 2 | ||
RTECS 번호 | DG2450000 | ||
TSCA | Yes | ||
위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 29224995 | ||
유해 물질 데이터 | 94-09-7(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 3042mg/kg | ||
기존화학 물질 | KE-01203 |
p-아미노안식향산에틸에스테르 C화학적 특성, 용도, 생산
개요
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.
화학적 성질
Benzocaine is a white odourless needle-like crystal, slightly soluble in water and easily soluble in organic solvents. For example: ethanol, chloroform, ether, soluble in almond oil, olive oil.용도
Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.정의
ChEBI: Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.Biological Functions
Benzocaine is a PABA derivative used primarily for topical application to skin and mucous membranes. Its low aqueous solubility allows it to stay at the site of application for long periods. Its minimal rate of absorption after topical administration is associated with a low incidence of systemic toxicity. Benzocaine is contraindicated in patients with known sensitivity to ester-linked anesthetics or PABA-containing compounds.일반 설명
Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.Because it is uncharged, it is not water soluble but is ideal fortopical applications. The onset of action is within 30 secondsand the duration of drug action is 10 to 15 minutes.Clinical Use
Benzocaine is used for endoscopy, bronchoscopy, and topicalanesthesia. Benzocaine is available as a 20% solution topicalspray, in a 1% gel for mucous membrane application, and a14% glycerin suspension for topical use in the outer ear.Toxicity to benzocaine can occur when the topical doseexceeds 200 to 300 mg resulting in methemoglobinemia.Infants and children are more susceptible to this and methemoglobinemiahas been reported after benzocaine lubricationof endotracheal tubes and after topical administration to treata painful diaper rash.Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer. Local contact may cause contact dermatitis. Used as a topical anesthetic and as a sun-screening agent. When heated to decomposition it emits highly toxic fumes of NOx. See also ETHYL ALCOHOL and ESTERSPurification Methods
Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]p-아미노안식향산에틸에스테르 준비 용품 및 원자재
원자재
준비 용품
Benzonatate
4-Fluorobenzoic acid
에틸4-(부틸아미노)벤조에이트
에틸 4-(디메틸아미노)벤조에이트
2-메톡시프로판
에틸4-(5-FORMYL-2-FURYL)벤조에이트
Diethyl (hydroxymethyl)phosphonate
1,3-프로판디올 비스(4-아미노벤조에이트)
4-AZIDOBENZOIC ACID
ETHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE
BOC-4-아미노벤질알콜
Viaminate
SGI-1027
4-(2-OXO-PROPYL)-BENZOIC ACID ETHYL ESTER
Benzocaine hydrochloride
2-아미노벤조티아졸-6-카르복실산
C.I.Disperse Yellow 102
p-아미노안식향산에틸에스테르 공급 업체
글로벌( 865)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 |
info@longyupharma.com | China | 2534 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 853 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3320 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3145 | 58 |