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4-Aminoantipyrine

CAS No.: 83-07-8

Chemical Name:: 4-Aminoantipyrine

Synonyms: 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene

CBNumber:: CB7485059

Molecular Formula:: C11H13N3O

Molecular Weight:: 203.24

MOL File:: 83-07-8.mol

MSDS File:: SDS

Modify Date:: 2024/3/25 11:48:53

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4-Aminoantipyrine Properties

Melting point	105-110 °C(lit.)
Boiling point	340 C
Density	0.8
refractive index	1.4930 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H₂O: 0.1 g/mL, clear
pka	pK1: 4.94(+1) (25°C)
form	Powder or Crystals
color	Yellow to yellow-brown
PH	7.1 (100g/l, H2O, 20℃)(slurry)
Odor	Odorless
Water Solubility	ca. 500 g/L (20 ºC)
Merck	14,591
BRN	181635
Stability	Stable. May be light sensitive.
LogP	-0.257 (est)
CAS DataBase Reference	83-07-8(CAS DataBase Reference)
NIST Chemistry Reference	Aminoantipyrene(83-07-8)
EPA Substance Registry System	4-Aminoantipyrene (83-07-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

22-36/37/38-20/21/22

Safety Statements

26-36-36/37/39

WGK Germany

RTECS

CD2480000

8-9-23

Hazard Note

Harmful

TSCA

Yes

HS Code

29331190

Toxicity

LD50 orally in Rabbit: 1700 mg/kg

NFPA 704

	1
2		1

4-Aminoantipyrine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A4382	4-Aminoantipyrine reagent grade	83-07-8	10G	₹5434.15	2022-06-14	Buy
Sigma-Aldrich(India)	A4382	4-Aminoantipyrine reagent grade	83-07-8	25G	₹5748.08	2022-06-14	Buy
Sigma-Aldrich(India)	A4382	4-Aminoantipyrine reagent grade	83-07-8	50G	₹6430.05	2022-06-14	Buy
Sigma-Aldrich(India)	A4382	4-Aminoantipyrine reagent grade	83-07-8	100G	₹9125.48	2022-06-14	Buy
Sigma-Aldrich(India)	A4382	4-Aminoantipyrine reagent grade	83-07-8	250G	₹17298.35	2022-06-14	Buy

Product number	Packaging	Price	Buy
A4382	10G	₹5434.15	Buy
A4382	25G	₹5748.08	Buy
A4382	50G	₹6430.05	Buy
A4382	100G	₹9125.48	Buy
A4382	250G	₹17298.35	Buy

4-Aminoantipyrine Chemical Properties,Uses,Production

Chemical Properties

Amber crystalline powder

Application

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Definition

ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.

Preparation

synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.

General Description

4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine Preparation Products And Raw materials

Raw materials

Ammonium bisulfite Iodine solution Sodium nitrite Antipyrine Starch paper

Sulfuric acid 2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one

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Preparation Products

Aminopyrine N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one AMMONIUM ALGINATE Ramifenazone

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide 2-CYANO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE 3-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)PROPANAMIDE AMINOPROPYLON

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4-Aminoantipyrine Suppliers

Global( 407)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ADVENT CHEMBIO PRIVATE LIMITED	+91-9821524116 +91-9821524116	Mumbai, India	353	58	Inquiry
SNA HEALTHCARE PVT LTD	+91-8652842416 +91-8652842416	Mumbai, India	88	58	Inquiry
PERFECT CHEMICAL	+91-9820465461 +91-9820465461	Mumbai, India	391	58	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry
KARPSCHEM LABORATORIES	+91-7249203006 +91-7249203006	Maharashtra, India	786	58	Inquiry
Sri Neelima Laboratories	+91-7981733602 +91-9849736989	Telangana, India	205	58	Inquiry
Orgamine Chemicals(I) Pvt Ltd	+91-9820080281 +91-9820080281	Maharashtra, India	451	58	Inquiry
S D Fine Chem Limited	+91-9323715856 +91-9323715856	Maharashtra, India	368	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry

Supplier	Advantage
ADVENT CHEMBIO PRIVATE LIMITED	58
SNA HEALTHCARE PVT LTD	58
PERFECT CHEMICAL	58
JSK Chemicals	58
KARPSCHEM LABORATORIES	58
Sri Neelima Laboratories	58
Orgamine Chemicals(I) Pvt Ltd	58
S D Fine Chem Limited	58
Alfa Aesar	58
Sisco Research Laboratories Pvt. Ltd.	58

4-Aminoantipyrine Spectrum

4-Aminoantipyrine(83-07-8)MS 4-Aminoantipyrine(83-07-8)¹HNMR 4-Aminoantipyrine(83-07-8)¹³CNMR 4-Aminoantipyrine(83-07-8)IR1 4-Aminoantipyrine(83-07-8)IR2

83-07-8(4-Aminoantipyrine)Related Search:

Cefazolin sodium salt Cefazolin Chlorodimethylphenylsilane Dimethyl ether Dimethyl fumarate

Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine Antipyrine Dimethyl sebacate Dimethyl sulfoxide

Propyphenazone 4,4'-Diaminodiphenylsulfone N,N-Dimethylformamide Acetaminophen Glucosamine

3,4'-DIAMINODIPHENYLMETHANE DIANTIPYRYLMETHANE EC 2.6.1.2

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4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on AKOS BBS-00007964 AMINOANTIPYRINE, 4- AMINOANTIPYRINE REAGENT AMINOPHENYZONE 1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE 1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE 4-AMINOANTIPYRENE 4-AMINOANTIPYRINE 4-AMINOANTIPYRINE REAGENT 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE 4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone 1,5-dimethyl-2-phenyl-4-aminopyrazolin 4-AMINOANTIPYRINE [4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE] 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one 1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone 4-Aminoantipyrine [for Biochemical Research] 4-Aminoantipyrine,98% 4-Aminoantipyrine;4-aminophenazone 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYR-AZOL IN-5-ON R. G., REAG. PH. EUR. I 4-AMINOANTIPYRINE FREE BASE 4-AminoantipyrinePuriss 4-AminoantipyrinePuriss(4-Aminophenazone) 4-AMINOBENZENE SULFONIC ACID( Sulphanilic Acid) 4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one Aminoantipyrene 4-amino antipyirine 4-AMINOANTIPYRIDINE (AMPYRONE) AMINOANTIPYRINE, 4-(RG) 4-Aminoantipyrine,4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 4-Aminoantipyrine p.a. AMINOANTIPYRINE, 4-(AMPYRONE)(RG) 4-AMINOANTIPYRINERESEARCH GRADE 1,5-Dimethyl-2-phenyl-4-aminopyrazoline 1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5] 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl- 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Aminophenazone (2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)aMine Minoazophene NSC 60242 (2,3-Dihydro-1,5-(diMethyl-d3)-3-oxo-2-phenyl-1H-pyrazol- 4-yl)aMine 1,2-Dihydro-1,5-(diMethyl-d3)-2-phenyl-4-aMino-3H-pyrazol-3-one 4-AMino-1,2-dihydro-1,5-(diMethyl-d3)-2-phenyl-3H-pyrazol-3-one 4-AMinoantipyrine-d3 4-Aminophenazone 4-AA 4-AMinoantipyrine 4-AMinoantipyrine, 98% 100GR 4-AMinoantipyrine, 98% 25GR 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLI 4-Aminoantipyrine puriss. p.a., Reag. Ph. Eur., >=99% FORMAMIDE DEIONIZED ULTRA PURE GRADE 4-Aminoantipyine