Cefazolin sodium salt
- CAS No.
- 27164-46-1
- Chemical Name:
- Cefazolin sodium salt
- Synonyms
- CEFAZOLIN SODIUM;Cefazolin sodium sterile;ancef;kefzol;CEFAZOLINE SODIUM;Cefazoline sodium sterile;sodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0;46083;Atirin;Azolin
- CBNumber:
- CB7403213
- Molecular Formula:
- C14H15N8NaO4S3
- Molecular Weight:
- 478.5
- MOL File:
- 27164-46-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/22 15:07:34
| Melting point | 190 °C |
|---|---|
| refractive index | 20 ° (C=10, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | crystalline powder |
| color | White to Off-White |
| Sensitive | Light Sensitive |
| Merck | 14,1917 |
| BRN | 3585038 |
| Stability | Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents. |
| InChIKey | LJIOGPYKTPCRAP-MVOALHSDNA-N |
| SMILES | C(C1=C(CS[C@]2([H])[C@H](NC(=O)CN3N=NN=C3)C(=O)N12)CSC1=NN=C(C)S1)(=O)O.[NaH] |&1:5,7,r| |
| LogP | 1.133 (est) |
| CAS DataBase Reference | 27164-46-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H334 | |||||||||
| Precautionary statements | P261-P280-P342+P311 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 42/43-36/37/38-20/21/22 | |||||||||
| Safety Statements | 22-36/37-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XI0390000 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead) | |||||||||
| NFPA 704 |
|
Cefazolin sodium salt price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C5020 | Cefazolin sodium salt 89.1-110.1% | 27164-46-1 | 100MG | ₹7588.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2681 | Cefazolin sodium salt certified reference material, pharmaceutical secondary standard | 27164-46-1 | 100MG | ₹11117.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5020 | Cefazolin sodium salt 89.1-110.1% | 27164-46-1 | 500MG | ₹16031.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C5020 | Cefazolin sodium salt 89.1-110.1% | 27164-46-1 | 1G | ₹27419.73 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2242 | Cefazolin Sodium Salt | 27164-46-1 | 5G | ₹6100 | 2022-05-26 | Buy |
Cefazolin sodium salt Chemical Properties,Uses,Production
Description
Cefazolin was synthesized by Fujisawa Pharmaceutical Co. in 1969. It was the first of the cephem antibiotics to introduce a thiadiazolylthiomethyl group at the 3 position and a tetrazole group at the 7 position in the side chain. Cefazolin is a parenteral cephem antibiotic showing better activity against gramnegative bacteria than cephalothin or cephaloridine. Its bactericidal activity, tissue distribution, and urinary excretion are excellent and it has wide clinical use.
Chemical Properties
White to off-white powder
Uses
Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial
Definition
ChEBI: A cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.
Clinical Use
Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle—here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.
Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.
Cefazolin sodium salt Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Nectar Lifesciences Ltd | +91-9357244445 +91-9357244445 | Punjab, India | 29 | 58 | Inquiry |
| JA Sterile Pvt Ltd | +91-9427679998 +91-9427679998 | Gujarat, India | 21 | 58 | Inquiry |
| Concept Pharmaceuticals Ltd | +91-2242418888 +91-2242418888 | Maharashtra, India | 19 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| AVIK PHARMACEUTICAL LIMITED | +91-22-67685000 | New Delhi, India | 54 | 58 | Inquiry |
| Pluto International | 09820708841 | Mumbai, India | 57 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Vitus Global Inc | 91-11-40516279 | Delhi, India | 91 | 58 | Inquiry |
| Nest Life Science Pvt., Ltd. | 91-79-26586039 | Gujarat, India | 26 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Aurobindo Pharma Limited | 58 |
| Nectar Lifesciences Ltd | 58 |
| JA Sterile Pvt Ltd | 58 |
| Concept Pharmaceuticals Ltd | 58 |
| Indogulf Group | 58 |
| AVIK PHARMACEUTICAL LIMITED | 58 |
| Pluto International | 58 |
| Anand Agencies | 58 |
| Vitus Global Inc | 58 |
| Nest Life Science Pvt., Ltd. | 58 |
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