Diclofenac sodium
- CAS No.
- 15307-79-6
- Chemical Name:
- Diclofenac sodium
- Synonyms
- DICLOFENAC SODIUM SALT;VOLTAREN;Solaraze;tsudohmin;SODIUM 2-(2,6-DICHLOROANILINO)PHENYLACETATE;N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid sodium salt;Naclof;Voldal;gp45840;kriplex
- CBNumber:
- CB5474464
- Molecular Formula:
- C14H10Cl2NNaO2
- Molecular Weight:
- 318.13
- MOL File:
- 15307-79-6.mol
- Modify Date:
- 2024/6/3 16:25:23
| Melting point | 288-290°C |
|---|---|
| Density | 0.781 g/cm3 |
| storage temp. | room temp |
| solubility | H2O: 50 mg/mL |
| form | White solid |
| pka | 4(at 25℃) |
| color | White to Almost white |
| Water Solubility | Soluble in water to 50mg/ml. |
| Merck | 14,3081 |
| BCS Class | 2 |
| Stability | Stable. |
| InChI | InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
| InChIKey | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
| SMILES | C1(=CC=CC=C1CC([O-])=O)NC1=C(Cl)C=CC=C1Cl.[Na+] |
| CAS DataBase Reference | 15307-79-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H361d-H372-H411 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P273-P301+P310 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36/37/38-63 | |||||||||
| Safety Statements | 22-36/37-45-36-26-60-20 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AG6330000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29224999 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp) | |||||||||
| NFPA 704 |
|
Diclofenac sodium price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D6899 | Diclofenac sodium salt | 15307-79-6 | 10G | ₹7967.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1144 | Diclofenac sodium salt Pharmaceutical Secondary Standard; Certified Reference Material | 15307-79-6 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D6899 | Diclofenac sodium salt | 15307-79-6 | 25G | ₹16670.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D6899 | Diclofenac sodium salt | 15307-79-6 | 100G | ₹52468.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93484 | Diclofenac sodium salt analytical standard | 15307-79-6 | 100MG | ₹5260.95 | 2022-06-14 | Buy |
Diclofenac sodium Chemical Properties,Uses,Production
Description
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Chemical Properties
Off-White Crystalline Solid
Uses
Diclofenac sodium is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
Definition
ChEBI: Diclofenac sodium is the sodium salt of diclofenac. It contains a diclofenac(1-).
World Health Organization (WHO)
The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diclofenac is a derivative of benzeneacetic acid. It is categorized under the class of non-steroidal anti-inflammatory drugs (NSAIDs). It shows inflammatory, analgesic and antipyretic activities.
Clinical Use
Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Side effects
The structure of diclofenac is a hybrid of a fenamate and an arylacetic acid. The compound is used as its sodium salt for the symptomatic relief of rheumatoid arthritis and osteoarthritis, including degenerative joint disease of the hip. The recommended dose is 75 – 150 mg/d which is clinically equivalent to 3.6g/d of aspirin. Gastrointestinal problems (ulceration and bleeding) and adverse CNS reactions (dizziness and headache) are the most commonly encountered adverse effects.
Synthesis
Synthesis: Acylation of N-phenyl-2,6- dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2,6- dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.
Diclofenac sodium Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Reenold Enterprises | +91-8208173540 +91-8208173540 | Maharashtra, India | 28 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Globus Pharmachem (Para Products Pvt Ltd) | +91-1204198900 +91-9899370547 | Uttar Pradesh, India | 22 | 58 | Inquiry |
| Rutu Chemicals | +91-9904014859 +91-9904014859 | Gujarat, India | 10 | 58 | Inquiry |
| Saral Chemtech LLP | +91-9045505010 +91-9760958282 | Maharashtra, India | 12 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Frolic Pharmachem | 58 |
| Reenold Enterprises | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Medi Pharma Drug House | 58 |
| Globus Pharmachem (Para Products Pvt Ltd) | 58 |
| Rutu Chemicals | 58 |
| Saral Chemtech LLP | 58 |
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