6-Aminocaproic acid
- CAS No.
- 60-32-2
- Chemical Name:
- 6-Aminocaproic acid
- Synonyms
- 6-AMINOHEXANOIC ACID;ACS;Aminocaproic;6-aminohexanoate;EACA;Amicar;H-ACP-OH;Hepin;177 J.D;aminocaproic acid,EACA
- CBNumber:
- CB5223888
- Molecular Formula:
- C6H13NO2
- Molecular Weight:
- 131.17
- MOL File:
- 60-32-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:08:52
| Melting point | 207-209 °C (dec.) (lit.) |
|---|---|
| Boiling point | 242.49°C (rough estimate) |
| Density | 1.042 g/cm3 |
| vapor pressure | <0.1 hPa (20 °C) |
| refractive index | 1.4870 (estimate) |
| Flash point | 207-209°C |
| storage temp. | Store below +30°C. |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 4.373(at 25℃) |
| color | white |
| Odor | Odorless |
| PH | 7.0-7.5 (50g/l, H2O, 20℃) |
| Water Solubility | SOLUBLE |
| Merck | 14,432 |
| BRN | 906872 |
| InChIKey | SLXKOJJOQWFEFD-UHFFFAOYSA-N |
| LogP | 0.027 (est) |
| CAS DataBase Reference | 60-32-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Hexanoic acid, 6-amino-(60-32-2) |
| EPA Substance Registry System | Hexanoic acid, 6-amino- (60-32-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H320-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MO6300000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29224995 | |||||||||
| Hazardous Substances Data | 60-32-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy) | |||||||||
| NFPA 704 |
|
6-Aminocaproic acid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A7824 | 6-Aminocaproic acid BioUltra, ≥99% | 60-32-2 | 25G | ₹4838.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7824 | 6-Aminocaproic acid BioUltra, ≥99% | 60-32-2 | 100G | ₹10944.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1224 | Aminocaproic acid Pharmaceutical Secondary Standard; Certified Reference Material | 60-32-2 | 1G | ₹8346.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7824 | 6-Aminocaproic acid BioUltra, ≥99% | 60-32-2 | 500G | ₹36198.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7824 | 6-Aminocaproic acid BioUltra, ≥99% | 60-32-2 | 1KG | ₹60154.53 | 2022-06-14 | Buy |
6-Aminocaproic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform.
Definition
ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.
Preparation
6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide.
Application
6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.
6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect.
General Description
6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity.
Mechanism of action
Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.
Safety Profile
Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.
6-Aminocaproic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TRC FINE CHEMS | +91-7400278327 +91-8097105248 | Mumbai, India | 73 | 58 | Inquiry |
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) | +91-9100091731 +91-9573334999 | Telangana, India | 57 | 58 | Inquiry |
| SETV ASRV LLP | +91-9731133411 +91-9731133411 | Telangana, India | 437 | 58 | Inquiry |
| Micro Labs Ltd | 08048372692Ext 280 | Karnataka, India | 16 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Oxford laboratories | +91 250 239 0032 | Maharashtra, India | 652 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TRC FINE CHEMS | 58 |
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| JSK Chemicals | 58 |
| Neugen Labs | 58 |
| Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) | 58 |
| SETV ASRV LLP | 58 |
| Micro Labs Ltd | 58 |
| Clearsynth Labs | 58 |
| Oxford laboratories | 58 |
| Pharma Affiliates | 58 |
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