N-BOC-1,6-diaminohexane
- CAS No.
- 51857-17-1
- Chemical Name:
- N-BOC-1,6-diaminohexane
- Synonyms
- tert-Butyl (6-aMinohexyl)carbaMate;N-BOC-1,6-DIAMINOHEXANE;N-BOC-1,6-HEXANEDIAMINE;TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE;tert-butyl (6-aMinohexyl)carbaMate hydrochloride;AURORA KA-7567;AURORA KA-7545;AURORA KA-4392;Boc-NH-(CH2)6-NH2;TIMTEC-BB SBB006530
- CBNumber:
- CB0702254
- Molecular Formula:
- C11H24N2O2
- Molecular Weight:
- 216.32
- MOL File:
- 51857-17-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Boiling point | 106-110 °C (0.3 mmHg) |
|---|---|
| Density | 0.965 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 125 °C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in dichloromethane and ethyl acetate. |
| pka | 12.93±0.46(Predicted) |
| form | Viscous Liquid |
| color | Clear light yellow |
| Sensitive | Air Sensitive |
| BRN | 2089264 |
| InChIKey | RVZPDKXEHIRFPM-UHFFFAOYSA-N |
| CAS DataBase Reference | 51857-17-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2735 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29241900 | |||||||||
| NFPA 704 |
|
N-BOC-1,6-diaminohexane price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 79229 | N-Boc-1,6-hexanediamine ≥98.0% (NT) | 51857-17-1 | 1G | ₹4330 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 79229 | N-Boc-1,6-hexanediamine ≥98.0% (NT) | 51857-17-1 | 5G | ₹15003.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A1375 | N-(tert-Butoxycarbonyl)-1,6-diaminohexane min. 97.0 % | 51857-17-1 | 1G | ₹2300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1375 | N-(tert-Butoxycarbonyl)-1,6-diaminohexane min. 97.0 % | 51857-17-1 | 5G | ₹9200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1375 | N-(tert-Butoxycarbonyl)-1,6-diaminohexane min. 97.0 % | 51857-17-1 | 25G | ₹19300 | 2022-05-26 | Buy |
N-BOC-1,6-diaminohexane Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
N-Boc-1,6-diaminohexane is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.
Application
N-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:
Biodegradable poly(disulfide amine)s for gene delivery.
A multifunctional dendrimer for theranostics.
Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
Self-assembled monolayers (SAMs) that resist adsorption of proteins.
[N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.
Preparation
synthesis of N-BOC-1,6-diaminohexane: 1,6-Diaminohexane 3 (Fig. 1) (100 g, 0.86 mol) was dissolved in CH2Cl2 (300 ml) and cooled in an ice bath to 0–3°C. To the stirred solution 0.3 eq. di-tert-butyl bicarbonate (62.6 g, 0.29 mol) was added slowly over a period of 1 h. The reaction was allowed to warm up to r.t., and proceeded overnight. The reaction mixture was extracted with saturated aqueous NaHCO3 (50 ml, three times). The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCl and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaO3, and extracted with ethyl acetate. The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCL and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaOH, and extracted with ethyl acetate. The organic extracts were pooled, dried over Na2SO4 and evaporated to give 10.5 g of homogeneous N-BOC-1, 6- diaminohexane 2c (Fig. 1) as a yellow oil which was used without further purification.
TLC Rf 0.51; 1H NMR (CDCL3) d 4.54 (bs, 1H; NH), 3.05 1 2.62 (m, 4H; NCH2), 1.41 (m, 9H; CH3), 1.29 (m, 8H; CH2).
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties on the polymerization methods
N-BOC-1,6-diaminohexane Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Eburon Organics (I) Pvt, Ltd | +91 260 240 0894 | Gujarat, India | 114 | 58 | Inquiry |
| Anji Biosciences | +91 40 40154989 | Hyderabad, India | 201 | 58 | Inquiry |
| Denisco Chemicals Pvt Ltd | +91 40 23552990 | Hyderabad, India | 133 | 58 | Inquiry |
| Siri Life Sciences Pvt Ltd | +91 9000234689 | Andhra Pradesh, India | 134 | 58 | Inquiry |
| SRC Laboratories PrivateLtd | + 91 40-230 77999 | Hyderabad, India | 75 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SRC Laboratories Pvt Ltd | +91 (40) 2307-7999 | New Delhi, India | 243 | 50 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Eburon Organics (I) Pvt, Ltd | 58 |
| Anji Biosciences | 58 |
| Denisco Chemicals Pvt Ltd | 58 |
| Siri Life Sciences Pvt Ltd | 58 |
| SRC Laboratories PrivateLtd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SRC Laboratories Pvt Ltd | 50 |
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