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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Aminopyridine >4-Dimethylaminopyridine

4-Dimethylaminopyridine

4-Dimethylaminopyridine Structure
CAS No.
1122-58-3
Chemical Name:
4-Dimethylaminopyridine
Synonyms
DMAP;N,N-Dimethylpyridin-4-amine;N,N-Dimethyl-4-aminopyridine;p-Dimethylaminopyridine;4-(N,N-dimethlyamino)pyridine;4,4-dimethylaminopyridine;4-(Dimethylamino)pyridine, 99%, prilled;26DCLPY;AURORA KA-6495;4-DiMethylaMin
CBNumber:
CB9852862
Molecular Formula:
C7H10N2
Molecular Weight:
122.17
MOL File:
1122-58-3.mol
MSDS File:
SDS
Modify Date:
2024/6/19 22:55:17
Request For Quotation

4-Dimethylaminopyridine Properties

Melting point 112 °C
Boiling point 162 °C
Density 0.906 g/mL at 25 °C
vapor pressure 0.169 hPa at 20 °C
refractive index n20/D 1.431
Flash point 110 °C
storage temp. Store below +30°C.
solubility methanol: 50 mg/mL, clear
form prilled
pka pKa (20°): 9.7
color off-white to yellow
Odor characteristic odor
PH Range 9.7 (10% aq soln)
PH 11 (60g/l, H2O, 20℃)
Water Solubility 76 g/L (25 ºC)
Merck 14,3389
BRN 110354
Stability Stable. Incompatible with acids, oxidizing agents.
LogP 1.34 at 25℃
CAS DataBase Reference 1122-58-3(CAS DataBase Reference)
NIST Chemistry Reference 4-Pyridinamine, N,N-dimethyl-(1122-58-3)
EPA Substance Registry System 4-(Dimethylamino)pyridine (1122-58-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H331-H310-H315-H318-H370-H411
Precautionary statements  P262-P273-P280-P301+P310-P302+P352+P310-P305+P351+P338
Hazard Codes  T,C,T+,Xn,F
Risk Statements  25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19
Safety Statements  36/37/39-45-28A-26-28-36/37-53-27-22-16
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  US8400000
Autoignition Temperature 420 °C
Hazard Note  Toxic/Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29333999
Toxicity LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg
NFPA 704
1
3 0

4-Dimethylaminopyridine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.20499 4-(Dimethylamino)pyridine for synthesis 1122-58-3 5G ₹3989.99 2022-06-14 Buy
Sigma-Aldrich(India) 8.20499 4-(Dimethylamino)pyridine for synthesis 1122-58-3 25G ₹8919.99 2022-06-14 Buy
Sigma-Aldrich(India) 8.20499 4-(Dimethylamino)pyridine for synthesis 1122-58-3 100G ₹15130.01 2022-06-14 Buy
Sigma-Aldrich(India) PHR2925 Valacyclovir Related Compound G certified reference material, pharmaceutical secondary standard 1122-58-3 500MG ₹41308.2 2022-06-14 Buy
Sigma-Aldrich(India) 8.51055 DMAP 4-(Dimethylamino)pyridine Novabiochem? 1122-58-3 25G ₹3350 2022-06-14 Buy
Product number Packaging Price Buy
8.20499 5G ₹3989.99 Buy
8.20499 25G ₹8919.99 Buy
8.20499 100G ₹15130.01 Buy
PHR2925 500MG ₹41308.2 Buy
8.51055 25G ₹3350 Buy

4-Dimethylaminopyridine Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

4-Dimethylaminopyridine (Valaciclovir EP Impurity G; Valacyclovir USP Related Compound G) is a highly efficient catalyst for acylation reactions.

General Description

Valacyclovir Related Compound G, also called as 4-(Dimethylamino)pyridine (DMAP) is an excellent catalyst for acylation of hindered alcohols and in chemical transformations. It is highly nucleophilic in nature.

Hazard

4-Dimethylaminopyridine (4-DMAP) is readily absorbed through the skin and is highly toxic by skin absorption. It also causes skin and eye burns. All skin and eye contact and inhalation should be avoided. Appropriate OSHA/ MSHA-approved respirator, chemical-resistant gloves and impervious or disposable protective clothing should be worn. Work should be carried out in a chemical fume hood.

Solubility in organics

4-Dimethylaminopyridine can be soluble in methanol, benzene, ethyl acetate, chloroform, methylene chloride, acetone, and acetic acid. Less soluble in ether, diisopropyl ether, cyclohexane, hexane, and water.

Purification Methods

Recrystallise DMAP from toluene [Sadownik et al. J Am Chem Soc 108 7789 1986]. [Beilstein 22 V 112.] § A polystyrene supported version (PS-DMAP) is commercially available.

4-Dimethylaminopyridine Preparation Products And Raw materials

Raw materials

Hexamethylphosphoramide 4-Hydroxypyridine Pyridine

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-Hydroxy-4-(trifluoromethyl)pyrimidine 2-Chloro-4-(trifluoromethyl)pyrimidine Docetaxel 1-(2-PYRROLIDINOETHYL)PIPERAZINE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBALDEHYDE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 2-Hydrazinyl-1-morpholinoethanone 4-TRIFLUOROMETHYL-N-METHYLANILINE 97
1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 1-ACETYL-5-BROMOINDOLINE N4-Benzoylcytosine 2-Acetylamino-4-methylpyridine 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE
Boc-L-beta-Homoproline BETA-(4-ACETOXYPHENYL)PROPIONIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE TERT-BUTYL 5-FORMYLTHIAZOL-2-YLCARBAMATE 1-TERT-BUTYL-4-BROMO-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE
3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one Aniracetam MONO-METHYL SUCCINATE 2-Aminoisonicotinic acid Ethyl 2-Aminoisonicotinate
4-AMINOBENZANILIDE 4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID 1-TERT-BUTYL-4-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 3-Hydrazinyl-1-morpholinopropan-1-one 2'-BROMOACETANILIDE
LIMAPROST 4-BROMO-5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE 2,2,2-TRIFLUORO-1-(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)ETHANONE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone (2R)-(-)-Glycidyl tosylate
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4-Dimethylaminopyridine Suppliers

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Supplier Advantage
BTC pharm India 58
CLEARSYNTH LABS LTD. 58
ANJI BIOSCIENCES 58
SRI HAIMAVATHI ORGANICS 58
GSV speciality chemicals 58
Island Veer Chemie Pvt Ltd 58
Vardhaman P Golechha 58
Hyderabad 58
Suposha Life Sciences 58
Varna Chems 58

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AKOS BBS-00004314 4-(DIMETHYLAMINO)PYRIDINE SOLUTION 4-(Dimethylamino)pyridine, ReagentPlus, 99% N,N'-DIMEHTYL-4-PYRIDINAMINE 4-(Dimethylamino)PyridineForSynthesis 4-Dimethylaminopyridine,>99% Dmap(4-Dimethylaminopyridine) 4,4-DIMETHYLAMINOPYRIDINE (DMAP) 4-(DIMETHYLAMINO)PYRIDINE 99.7% 4-Dimethylaminopyridine 4-DMAP DIMETHYLPYRIDIN-4-YLAMINE 4-Amino-2,6-dimethyl-8-(2’-deoxy--D-ribofuranosyl)-7(8H)-pteridone 4-(DiMethylaMino)pyridine puruM, >=98.0% (NT) 4-(DiMethylaMino)pyridine ReagentPlus(R), >=99% 4-Dimethylaminopyridine N,N-Dimethylpyridin-4-amine Valaciclovir impurity G (PhEur) 4-(Dimethylamino)pyridine, ChemDose? tablets The diMethyl aMinopyridine Famciclovir Dimethylaminopyridine Impurity (USP) 4-(Dimethylamino)pyridine solution 0.5 M in ethyl acetate 4-(Dimethylamino)pyridine, prilled, 99% 4-DMA PYRIDINA 4-Dimethylaminopyridine≥ 99% (HPLC) DMAP 4-(Dimethylamino)pyridine Novabiochem 4-DIMETHYLAMINOPYRIDINE extrapure 4-(Dimethylamino)-pyridine, synthesis grade DMAP solution 4-(Dimethylamino)pyridine, ChemDose(R) tablets DMAP, ChemDose(R) impregnated tablets, ChemDose(R), 4-(Dimethylamino)pyridine impregnated tablets N,N-Dimethyl(4-pyridyl)amine N,N-Dimethylpyridin-4-amine, DMAP Valacyclovir Related Compound G (50 mg) (N,N-dimethylpyridin-4-amine) DiMethyl-pyridin-4-yl-aMine (DMAP) 4-DiMethylaMinopyridine, 99% 100GR 4-DiMethylaMinopyridine, 99% 25GR 4-DiMethylaMinopyridine, 99% 5GR DMAP N-(4-Pyridyl)dimethylamine Valacyclovir IMpurity-G DMAP)4-DiMethylaMinopyr Valacyclovir Related CoMpound G (4-DMAP) 4-(dimethylamino)-pyridin 4-Dimethylaminepyridine gamma-(Dimethylamino)pyridine n,n-dimethyl-4-pyridinamin Pyridine, 4-(dimethylamino)- Valacyclovir Related Compound G (R02250) 4-DimethylaminopyridineQ: What is 4-Dimethylaminopyridine Q: What is the CAS Number of 4-Dimethylaminopyridine Q: What is the storage condition of 4-Dimethylaminopyridine Q: What are the applications of 4-Dimethylaminopyridine 4-Dimethylaminopyridine (DMAP) extrapure, 98% Valacyclovir Related Compound G (N,N-dimethylpyridin-4-amine) (1707894) Valaciclovir EP Impurity G imethylaminopyridine Valacyclovir Impurity 7(Valacyclovir EP Impurity G) JACS-1122-58-3 N,N-Dimethylpyridin-4-amine DMAP 4-Dimethylaminopyridine 1122-58-3 In stock 4-Dimethylaminopyridine 1122-58-3 In stock N,N-Dimethylpyridin-4-amine DMAP 4-DIMETHYLAMINOPYRIDINE, 99%4-DIMETHYLAMINOPYRIDINE, 99%4-DIMETHYLAMINOPYRIDINE, 99% Valacyclovir EP Impurity G