3,4-Diaminopyridine
- CAS No.
- 54-96-6
- Chemical Name:
- 3,4-Diaminopyridine
- Synonyms
- Amifampridine;PYRIDINE-3,4-DIAMINE;3,4-diamino-pyridin;3,4-DAP;NSC 521760;Amipyridine;WLN: T6NJ CZ DZ;TIMTEC-BB SBB004341;diamino-3,4pyridine;4,5-diaminopyridine
- CBNumber:
- CB6676074
- Molecular Formula:
- C5H7N3
- Molecular Weight:
- 109.13
- MOL File:
- 54-96-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/26 13:21:49
| Melting point | 216-218 °C (lit.) |
|---|---|
| Boiling point | 194.6°C (rough estimate) |
| Density | 1.1118 (rough estimate) |
| refractive index | 1.5340 (estimate) |
| Flash point | 240 °C |
| storage temp. | Store below +30°C. |
| solubility | 30g/l |
| pka | 9.17±0.12(Predicted) |
| form | Crystalline Powder |
| color | Brownish to brown-gray |
| Water Solubility | 24 g/L (20 ºC) |
| Merck | 14,2986 |
| BRN | 110232 |
| InChI | InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8) |
| InChIKey | OYTKINVCDFNREN-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(N)=C1N |
| CAS DataBase Reference | 54-96-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330-H311-H319 | |||||||||
| Precautionary statements | P260-P264-P280-P302+P352+P312-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+,T,Xi | |||||||||
| Risk Statements | 25-26-36/37/38 | |||||||||
| Safety Statements | 26-28-36/37/39-45-37/39-28A-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7600000 | |||||||||
| F | 10-23 | |||||||||
| Autoignition Temperature | 480 °C | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orally in Rabbit: 47 mg/kg LD50 dermal Rabbit > 200 mg/kg | |||||||||
| NFPA 704 |
|
3,4-Diaminopyridine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7148 | 3,4-Diaminopyridine ≥98% | 54-96-6 | 1G | ₹3377.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7148 | 3,4-Diaminopyridine ≥98% | 54-96-6 | 5G | ₹9287.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.18392 | 3,4-Diaminopyridine for synthesis | 54-96-6 | 1G | ₹3190 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.18392 | 3,4-Diaminopyridine for synthesis | 54-96-6 | 5G | ₹11830 | 2022-06-14 | Buy |
| ALFA India | ALF-A12465-14 | 3,4-Diaminopyridine, 98+% | 54-96-6 | 25g | ₹44952 | 2022-05-26 | Buy |
3,4-Diaminopyridine Chemical Properties,Uses,Production
Chemical Properties
brownish to brown-grey crystalline powder
Uses
It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.
Indications
3,4-diaminopyridine has been used to treat Lambert Eaton myasthenia (LEM) for thirty years despite the lack of conclusive evidence of efficacy.
Lambert–Eaton myasthenic syndrome is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction, which result from impaired release of acetylcholine from cholinergic nerve terminals. It is frequently associated with cancer, it is autoimmune-mediated, and treatment has been unsatisfactory.
The drug 3,4-diaminopyridine (3,4-DAP) increases neurotransmitter release and also the action potential (by blocking potassium conductance); these actions lead to a nonspecific excitatory effect on the cholinergic system, and provide benefit. It should be taken orally, 4-5 times per day. Adverse effects due to CNS excitation (insomnia, seizures) can occur.
Purification Methods
It crystallises from *benzene and is stored under N2 because it is deliquescent and absorbs CO2. [Beilstein 22/11 V 266.]
3,4-Diaminopyridine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| visachem pvt ltd | +91-919550300259 +91-9704672724 | Telangana, India | 65 | 58 | Inquiry |
| SUMUKHA LIFESCIENCES | +919000487488 | Hyderabad, India | 200 | 58 | Inquiry |
| SIRI LIFE SCIENCES | +91-9000234689 +91-9000234689 | Hyderabad, India | 177 | 58 | Inquiry |
| ChemBioReas Life Sciences | +91-7989264158 +91-7989264158 | Hyderabad, India | 82 | 58 | Inquiry |
| Credas Labs Pvt Ltd | +91 9133918031 | Hyderabad, India | 119 | 58 | Inquiry |
| sales@alchemecopharma.com | +91-91777666469 +91-7799666469 | Telangana, India | 83 | 58 | Inquiry |
| CHATURYA BIOTECH | +91-7702707258 +91-7702707258 | Telangana, India | 479 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| M M Kemicals | +91-7032683572 +91-9989927761 | Telangana, India | 38 | 58 | Inquiry |
| Vital synthetics | +917799889789 | Telangana, India | 98 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| visachem pvt ltd | 58 |
| SUMUKHA LIFESCIENCES | 58 |
| SIRI LIFE SCIENCES | 58 |
| ChemBioReas Life Sciences | 58 |
| Credas Labs Pvt Ltd | 58 |
| sales@alchemecopharma.com | 58 |
| CHATURYA BIOTECH | 58 |
| Shilpa Medicare Limited (SML) | 58 |
| M M Kemicals | 58 |
| Vital synthetics | 58 |
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