4-Hydroxypyridine
- CAS No.
- 626-64-2
- Chemical Name:
- 4-Hydroxypyridine
- Synonyms
- PYRIDIN-4-OL;4-PYRIDINOL;4HYDROXYPRIDINE;4-Hydroxypyride;1H-Pyridin-4-ol;Compound Fr14055;4-HYDROXYPYRIDINE;TIMTEC-BB SBB000030;4-hydroxyl pyridine; 4-Hydroxypyridone
- CBNumber:
- CB6303828
- Molecular Formula:
- C5H5NO
- Molecular Weight:
- 95.1
- MOL File:
- 626-64-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/21 9:48:07
| Melting point | 150-151 °C (lit.) |
|---|---|
| Boiling point | 230-235 °C/12 mmHg (lit.) |
| Density | 1.1418 (rough estimate) |
| refractive index | 1.5939 (estimate) |
| Flash point | 221 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder or Chunks |
| pka | 3.2(at 20℃) |
| color | Beige to light brown |
| Water Solubility | Soluble |
| BRN | 105800 |
| InChIKey | GCNTZFIIOFTKIY-UHFFFAOYSA-N |
| LogP | -1.300 (est) |
| CAS DataBase Reference | 626-64-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Pyridinol(626-64-2) |
| EPA Substance Registry System | 4-Pyridinol (626-64-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36-37/39-39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU7701450 | |||||||||
| F | 3-8-10 | |||||||||
| Hazard Note | Harmful/Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4-Hydroxypyridine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 120618 | 4-Hydroxypyridine 95% | 626-64-2 | 25G | ₹4427.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | CDS013613 | 4-hydroxypyridine AldrichCPR | 626-64-2 | 1G | ₹6170.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 120618 | 4-Hydroxypyridine 95% | 626-64-2 | 100G | ₹12795.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 120618 | 4-Hydroxypyridine 95% | 626-64-2 | 500G | ₹53345.6 | 2022-06-14 | Buy |
| ALFA India | ALF-A14586-36 | 4-Hydroxypyridine, 97% | 626-64-2 | 500g | ₹49334 | 2022-05-26 | Buy |
4-Hydroxypyridine Chemical Properties,Uses,Production
Description
4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].
Chemical Properties
Beige crystalline powder
Uses
4-Hydroxypyridine was used in the synthesis of (Ag3MoO3F3) (Ag3MoO4)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.
Definition
ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.
Purification Methods
Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]
References
[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.
4-Hydroxypyridine Preparation Products And Raw materials
Raw materials
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