4-Cyanophenol
- CAS No.
- 767-00-0
- Chemical Name:
- 4-Cyanophenol
- Synonyms
- 4-HYDROXYBENZONITRILE;4-HYDROXYBENZOHYDRAZIDE;P-CYANOPHENOL;PARA-CYANOPHENOL;Hydroxybenzonitrile;Benzonitrile, 4-hydroxy-;P-nitrile;AKOS 217-25;AKOS B004225;4-CYANOPHENOL
- CBNumber:
- CB6681698
- Molecular Formula:
- C7H5NO
- Molecular Weight:
- 119.12
- MOL File:
- 767-00-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/5 15:33:49
| Melting point | 110-113 °C(lit.) |
|---|---|
| Boiling point | 146 °C / 2mmHg |
| Density | 1.1871 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystalline Powder |
| pka | 7.97(at 25℃) |
| color | Off-white to beige-gray |
| Water Solubility | slightly soluble |
| BRN | 386130 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 767-00-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxybenzoic acid nitrile(767-00-0) |
| EPA Substance Registry System | Benzonitrile, 4-hydroxy- (767-00-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DI4375000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29269095 | |||||||||
| NFPA 704 |
|
4-Cyanophenol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C94009 | 4-Cyanophenol 95% | 767-00-0 | 25G | ₹1851.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C94009 | 4-Cyanophenol 95% | 767-00-0 | 5G | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C94009 | 4-Cyanophenol 95% | 767-00-0 | 100G | ₹6473.35 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0842 | 4-Hydroxybenzonitrile min. 98.0 % | 767-00-0 | 25G | ₹2100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0842 | 4-Hydroxybenzonitrile min. 98.0 % | 767-00-0 | 500G | ₹13700 | 2022-05-26 | Buy |
4-Cyanophenol Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder or chips. 4-Hydroxybenzonitrile [767-00-0], 4-cyanophenol, 1-cyano-4-hydroxybenzene, Mr 119.2, forms colorless crystals of mp 113℃. 4-Hydroxybenzonitrile is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia. The nitrile is used for the production of the herbicides 3,5-dibromo- and 3,5-diiodo-4- hydroxybenzonitrile (Bromoxynil, Ioxynil, May & Baker).
Uses
4-Cyanophenol is a precursor for the synthesis of a vasodilator, Levcromakalim. Bromination of 4-cyanophenol results in bromoxynil, a commercial herbicide. It can also be used as a component of deep eutectic solvent (DES) mixture.
Preparation
4-Cyanophenol is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia.
Purification Methods
Crystallise the phenol from pet ether, *benzene or water and keep it under vacuum over P2O5. [Bernasconi & Paschelis J Am Chem Soc 108 2969 1986.] [Beilstein 10 H 167, 10 IV 441.]
4-Cyanophenol Preparation Products And Raw materials
Raw materials
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| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
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| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| United Phosphorus Limited | +91-2271528737 +91-9004390689 | Mumbai, India | 32 | 58 | Inquiry |
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| Apiqule Pharmachem LLP | +91-9537957857 +91-9904897541 | Gujarat, India | 21 | 58 | Inquiry |
| Samruddhi Agro and Lifescience | +91-9923605583 +91-7028045583 | Ahmedabad, India | 8 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| Allchem Lifescience Pvt. Ltd | 58 |
| JSK Chemicals | 58 |
| CHEMAZON LABORATORIES | 58 |
| United Phosphorus Limited | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Apiqule Pharmachem LLP | 58 |
| Samruddhi Agro and Lifescience | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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