4-Hydroxyphenylacetic acid
- CAS No.
- 156-38-7
- Chemical Name:
- 4-Hydroxyphenylacetic acid
- Synonyms
- P-HYDROXYPHENYLACETIC ACID;PHPA;2-(4-hydroxyphenyl)acetic acid;4-Hydroxybenzeneacetic acid;4-carboxymethylphenol;4-Hydroxyphenylacetic;4-hydrophenylacetic acid;4-hydroxybenzeneaceticacid;Benzeneacetic acid, 4-hydroxy-;NSC 27460
- CBNumber:
- CB6314323
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MOL File:
- 156-38-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/30 19:23:35
| Melting point | 148-151 °C(lit.) |
|---|---|
| Boiling point | 234.6°C (rough estimate) |
| Density | 1.2143 (rough estimate) |
| vapor pressure | 0.007Pa at 25℃ |
| refractive index | 1.4945 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 50g/l |
| form | Crystalline Powder |
| pka | 4.50±0.10(Predicted) |
| color | White to cream or light tan |
| PH | 2.0-2.4 (30g/l, H2O, 20℃) |
| Water Solubility | Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water. |
| BRN | 1448766 |
| InChIKey | XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| LogP | 0.75 at 25℃ |
| CAS DataBase Reference | 156-38-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzeneacetic acid, 4-hydroxy-(156-38-7) |
| EPA Substance Registry System | Benzeneacetic acid, 4-hydroxy- (156-38-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AI2680000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29182990 | |||||||||
| NFPA 704 |
|
4-Hydroxyphenylacetic acid price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | H0290 | 4-Hydroxyphenylacetic Acid min. 99.0 % | 156-38-7 | 25G | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0290 | 4-Hydroxyphenylacetic Acid min. 99.0 % | 156-38-7 | 100G | ₹10800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0290 | 4-Hydroxyphenylacetic Acid min. 99.0 % | 156-38-7 | 500G | ₹15500 | 2022-05-26 | Buy |
| ALFA India | ALF-A15018-36 | 4-Hydroxyphenylacetic acid, 99% | 156-38-7 | 500g | ₹29793 | 2022-05-26 | Buy |
| ALFA India | ALF-A15018-22 | 4-Hydroxyphenylacetic acid, 99% | 156-38-7 | 100g | ₹5867 | 2022-05-26 | Buy |
4-Hydroxyphenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.
Uses
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
Definition
ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.
Preparation
4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.
4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
Purification Methods
Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]
4-Hydroxyphenylacetic acid Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Seema Finechem Industry LLP | +91-8451840941 +91-8451840941 | NaviMumbai, India | 43 | 58 | Inquiry |
| Indo Amines Ltd | +91-7045592702 +91-7045592702 | Mumbai, India | 42 | 58 | Inquiry |
| Sris Synthesis Pvt Ltd., | +91-9989522441 +91-9989522441 | Hyderabad, India | 282 | 58 | Inquiry |
| Clemetiz Pharmaceuticals Priavte Limited | +91-9922687058 +91-9922687058 | Maharashtra, India | 9 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| ASCENT FINE CHEM | +91 9869071684 | Gujarat, India | 18 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Aventus Labs | +91-7021872517 +91-9324342304 | Maharashtra, India | 168 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| Glenfin Chemicals Pvt Ltd | +91-9923430013 +91-9323802458 | Maharashtra, India | 63 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Seema Finechem Industry LLP | 58 |
| Indo Amines Ltd | 58 |
| Sris Synthesis Pvt Ltd., | 58 |
| Clemetiz Pharmaceuticals Priavte Limited | 58 |
| JSK Chemicals | 58 |
| ASCENT FINE CHEM | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Aventus Labs | 58 |
| S D Fine Chem Limited | 58 |
| Glenfin Chemicals Pvt Ltd | 58 |