Bufexamac
- CAS No.
- 2438-72-4
- Chemical Name:
- Bufexamac
- Synonyms
- j3;cp1044;feximac;mofenar;parfenac;droxaryl;droxarol;cp1044j3;flogicid;norfemac
- CBNumber:
- CB7768637
- Molecular Formula:
- C12H17NO3
- Molecular Weight:
- 223.27
- MOL File:
- 2438-72-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:17
| Melting point | 153-155° |
|---|---|
| Boiling point | 364.56°C (rough estimate) |
| Density | 1.1223 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol. |
| form | Solid |
| pka | 9.24±0.20(Predicted) |
| color | White to Off-White |
| Merck | 14,1474 |
| CAS DataBase Reference | 2438-72-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352+P333+P313+P363-P501 |
| WGK Germany | 2 |
| RTECS | AK8280000 |
| HS Code | 2928.00.2500 |
| Toxicity | LD50 orally in mice, rats: >8, >4 g/kg (Lambelin) |
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Bufexamac Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.
Definition
ChEBI: A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.
World Health Organization (WHO)
Bufexamac, an analgesic and anti-inflammatory agent, was introduced in 1974 for the topical treatment of a wide range of dermatoses. The drug is widely marketed and the World Health Organization is not aware of restrictive action having been taken elsewhere.
Contact allergens
Bufexamac is an arylacetic nonsteroidal anti-inflammatory drug. It induces allergic contact dermatitis, eczematous or erythema multiforme like type, and even generalized eruptions like acute generalized exanthematous pustulosis.
Bufexamac Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
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