Acetohydroxamic acid
- CAS No.
- 546-88-3
- Chemical Name:
- Acetohydroxamic acid
- Synonyms
- AHA;N-HYDROXYACETAMIDE;Acetylhydroxamic acid;Acetomenadione;Acetylhydroxylamine;NSC 5073;Lithostat;NSC 176136;NSC 408425;yangwosuan
- CBNumber:
- CB6395344
- Molecular Formula:
- C2H5NO2
- Molecular Weight:
- 75.07
- MOL File:
- 546-88-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 88-90 °C (lit.) |
|---|---|
| Boiling point | 133.7°C (rough estimate) |
| Density | 1.2269 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Methanol (Sparingly), Water (Sparingly) |
| form | Crystalline Solid |
| pka | 8.70(at 25℃) |
| color | White to pale yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,63 |
| BRN | 1739019 |
| Stability | Moisture and Temperature Sensitive |
| InChIKey | RRUDCFGSUDOHDG-UHFFFAOYSA-N |
| CAS DataBase Reference | 546-88-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide,N-hydroxy(546-88-3) |
| EPA Substance Registry System | Acetohydroxamic acid (546-88-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360 | |||||||||
| Precautionary statements | P201-P280-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-40 | |||||||||
| Safety Statements | 53-45-36/37/39-22 | |||||||||
| RIDADR | 3263 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AK8157000 | |||||||||
| Hazard Note | Toxic | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29225090 | |||||||||
| Toxicity | mmo-sat 160 mmol/plate JOPHDQ 3,557,80 | |||||||||
| NFPA 704 |
|
Acetohydroxamic acid price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 159034 | Acetohydroxamic acid 98% | 546-88-3 | 5G | ₹3258.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 159034 | Acetohydroxamic acid 98% | 546-88-3 | 10G | ₹6040.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 159034 | Acetohydroxamic acid 98% | 546-88-3 | 50G | ₹18088.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0051 | Acetohydroxamic Acid | 546-88-3 | 10G | ₹7400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A0051 | Acetohydroxamic Acid | 546-88-3 | 25G | ₹10800 | 2022-05-26 | Buy |
Acetohydroxamic acid Chemical Properties,Uses,Production
Description
Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.
Chemical Properties
White Crystalline Solid
Uses
Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Acetohydroxamic acid was used:
to study the mechanism of complexation of iron (III) with acetohydroxamic acid.
to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni.
in urease inhibition studies.
for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
General Description
Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pounding heartbeats or fluttering in your chest;
signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;
signs of a red blood cell disorder --pale or yellowed skin, dark colored urine, fever, confusion or weakness.
Common side effects may include:
headache during the first 2 days of treatment;
skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);
upset stomach, nausea, loss of appetite;
depressed mood;
anxiety, tremors, nervousness;
hair loss.
Safety Profile
Moderately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.
Acetohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| VIVAN Life Sciences Pvt. Limited. | +91(22) 2544 4584 / 2544 4585 | New Delhi, India | 138 | 50 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Central Drug House(P) Ltd. | 58 |
| Clearsynth Labs | 58 |
| VIVAN Life Sciences Pvt. Limited. | 50 |
| Pharma Affiliates | 58 |
546-88-3(Acetohydroxamic acid)Related Search:
1of4
chevron_right