Thioacetamide
![Thioacetamide Structure](CAS/GIF/62-55-5.gif)
- CAS No.
- 62-55-5
- Chemical Name:
- Thioacetamide
- Synonyms
- TAA;ETHANETHIOAMIDE;CH3CSNH2;THIOACETAMIDE ACS REAGENT;usafcb-21;USAF cb-21;usafek-1719;Thiacetamide;hioacetamide;Thioactamide
- CBNumber:
- CB7755552
- Molecular Formula:
- C2H5NS
- Molecular Weight:
- 75.13
- MOL File:
- 62-55-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/8 14:48:35
Melting point | 108-112 °C (lit.) |
---|---|
Boiling point | 111.7±23.0 °C(Predicted) |
Density | 1.37 |
refractive index | 1.5300 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
pka | 13.25±0.29(Predicted) |
form | Liquid |
color | Off-white to slightly beige |
PH | 5.2 (100g/l, H2O, 20℃) |
PH Range | 5.2 |
Water Solubility | 16.3 g/100 mL (25 ºC) |
Merck | 14,9319 |
BRN | 506006 |
Stability | Stability Incompatible with water, mineral acids. |
InChIKey | YUKQRDCYNOVPGJ-UHFFFAOYSA-N |
CAS DataBase Reference | 62-55-5(CAS DataBase Reference) |
NIST Chemistry Reference | Ethanethioamide(62-55-5) |
IARC | 2B (Vol. 7, Sup 7) 1987 |
EPA Substance Registry System | Thioacetamide (62-55-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H315-H319-H350-H412 | |||||||||
Precautionary statements | P201-P273-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 45-22-36/38-52/53 | |||||||||
Safety Statements | 53-45-61-99 | |||||||||
RIDADR | 2811 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AC8925000 | |||||||||
F | 10 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29309070 | |||||||||
Toxicity | MLD orally in rats: 200 mg/kg (Ambrose) | |||||||||
NFPA 704 |
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Thioacetamide price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 172502 | Thioacetamide reagent grade, 98% | 62-55-5 | 25G | ₹3399.05 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 172502 | Thioacetamide reagent grade, 98% | 62-55-5 | 100G | ₹3712.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 172502 | Thioacetamide reagent grade, 98% | 62-55-5 | 500G | ₹13866.83 | 2022-06-14 | Buy |
Sigma-Aldrich | 163678 | Thioacetamide ACS reagent, ≥99.0% | 62-55-5 | 25G | ₹4178.45 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 163678 | Thioacetamide ACS reagent, ≥99.0% | 62-55-5 | 25G | ₹4178.45 | 2022-06-14 | Buy |
Thioacetamide Chemical Properties,Uses,Production
Description
Thioacetamide (TAA) is not known to occur in nature. It is prepared by heating ammonium acetate and aluminum sulfide.
Chemical Properties
Thioacetamide is combustible, crystalline compound. Slight mercaptan odor.
Uses
Thioacetamide is a carcinogen, a hepatotoxicant. Thioacetamide induces acute chronic liver injury through the activation of protein synthesis of RNA, DNA, and gamma-glutamyl transpeptitase. Thioacetamide has been used in the synthesis of [email?protected] nano-array core-shell structure.
Definition
ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
General Description
White crystals with a mercaptan odor.
Air & Water Reactions
Slightly water soluble.
Reactivity Profile
Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .
Hazard
Toxic by ingestion and inhalation, a possible carcinogen.
Fire Hazard
Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES and MERCAPTANS.
Potential Exposure
Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel.
Carcinogenicity
Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
TAA’s production and use as a substitute for hydrogen sulfide in the laboratory may result in its release to the environment through various waste streams. If released to air, TAA’s estimated vapor pressure indicates that it will exist solely as a vapor in the ambient atmosphere. Vapor-phase TAA will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h. TAA was not biodegraded by activated sludge after 5 days, and therefore may be resistant to biodegradation in the environment. Hydrolysis is not expected since amides hydrolyze very slowly under environmental conditions. An estimated bioconcentration factor for TAA suggests that the potential for bioconcentration in aquatic organisms is low. TAA is expected to be highly mobile in soil, and to volatilize into the atmosphere from moist soil surfaces. In an aquatic environment, most of the substance will leave via volatilization and is not expected to adsorb to solids.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.
Thioacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Advantage |
---|---|
ORGANO FINE CHEMICALS | 58 |
SNECOFRi Pvt Ltd | 58 |
Ronak Chemicals | 58 |
JSK Chemicals | 58 |
AKASH PHARMA EXPORTS | 58 |
Artichempharma (Aarti Dye Chem) | 58 |
Loba Chemie Pvt., Ltd. | 58 |
Sachin Chemicals | 58 |
Organo Fine Chemicals | 60 |
FINAR LTD | 58 |
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