HYDROXYLAMINE
- CAS No.
- 7803-49-8
- Chemical Name:
- HYDROXYLAMINE
- Synonyms
- NH2OH;hydroxylamine,freebase;Hydroxylamine solution;HydroxylaMine in Methanol;FH-50;FH-50TM;Oxyammonia;Oxammonium;Hydroxyamine;azinous acid
- CBNumber:
- CB3345090
- Molecular Formula:
- H3NO
- Molecular Weight:
- 33.03
- MOL File:
- 7803-49-8.mol
- Modify Date:
- 2024/7/11 8:40:50
| Melting point | 7°C |
|---|---|
| Boiling point | >100 °C |
| Density | 1.078 g/mL at 25 °C |
| vapor pressure | 9 mm Hg ( 40 °C) |
| refractive index |
n |
| RTECS | NC2975000 |
| storage temp. | Store below +30°C. |
| solubility | Water |
| pka | pK (20°) 7.97 |
| form | white flakes or needles |
| color | white orthorhombic flakes or needles |
| Water Solubility | Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform. |
| Merck | 13,4853 |
| Stability | Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites. |
| InChIKey | AVXURJPOCDRRFD-UHFFFAOYSA-N |
| CAS DataBase Reference | 7803-49-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydroxylamine(7803-49-8) |
| EPA Substance Registry System | Hydroxylamine (7803-49-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |      GHS02,GHS05,GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H208-H290-H302-H315-H317-H318-H335-H351-H373-H400 | |||||||||
| Precautionary statements | P210-P212-P230-P233-P280-P305+P351+P338-P371+P380+P375-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 5-22-37/38-41-43-48/22-50-40-21/22 | |||||||||
| Safety Statements | 23-26-36/37/39-47-61-22-46 | |||||||||
| RIDADR | UN 3082 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 4.8 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 28251090 | |||||||||
| Toxicity | LD50 i.p. in mice: 1.83 mmol/kg (Smith, Layne) | |||||||||
| NFPA 704 |
|
HYDROXYLAMINE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.14441 | Hydroxylamine (50% solution in water) for synthesis | 7803-49-8 | 100ML | ₹6270 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.14441 | Hydroxylamine (50% solution in water) for synthesis | 7803-49-8 | 500ML | ₹19320.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 467804 | Hydroxylamine solution 50?wt. % in H2O, 99.999% | 7803-49-8 | 10ML | ₹5336.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 467804 | Hydroxylamine solution 50?wt. % in H2O, 99.999% | 7803-49-8 | 50ML | ₹12113.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 438227 | Hydroxylamine solution 50?wt. % in H2O | 7803-49-8 | 50ML | ₹3864.53 | 2022-06-14 | Buy |
HYDROXYLAMINE Chemical Properties,Uses,Production
Description
Hydroxylamine was first synthesized by Wilhem Clemens Lossen in 1865 in the laboratory of Wilhelm Heinrich Heintz while working in Halle. The Lossen synthesis originally generated hydroxylamine in aqueous solution. Anhydrous hydroxylamine was prepared later by Lobry de Bruyn and Crismer in 1891. The free base is extremely volatile, and industrial-scale production has been fraught with problems, including large explosions at facilities in the United States and Japan. Much of the hydroxylamine produced and transported is in salt form or as a dilute aqueous solution.
Chemical Properties
slightly yellow liquid
Physical properties
White crystalline solid; orthogonal plates or needles; unstable; density 1.21g/cm3at 20°C; melts at 33°C; vaporizes at 58°C; very soluble in water, liquidammonia and lower alcohols; sparingly soluble in most other organic solvents;decomposes in hot water; pKa5.94 at 25°C.
Uses
Hydroxylamine is used as a reducing agent in photography, in synthetic and analytical chemistry, as an antioxidant for fatty acids and soaps, and as a dehairing agent for hides. In addition, hydroxylamine is used in the production of cyclohexanone oxime, an isomer of caprolactam, which is an intermediate in the production of nylon-6. In the semiconductor industry, hydroxylamine can be a component of a solution that dissolves a photoresist following lithography. Hydroxylamine can also be used to selectively cleave asparaginyl-glycine peptide bonds.
Definition
ChEBI: The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria.
Preparation
Hydroxylamine is unstable as a free base. It is prepared from hydroxy-lamine hydrochloride, NH2OH?HCl, which is obtained by electrolytic reduc-tion of ammonium chloride solution. The hydrochloride undergoes alkalinedecomposition to hydroxylamine, which is collected by vacuum distillation.
General Description
Odorless white crystalline solid. Sinks and mixes with water.
Air & Water Reactions
Decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. Reacts with water or steam to produce heat and corrosive liquids.
Reactivity Profile
HYDROXYLAMINE is a white solid, thermally unstable, decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. HYDROXYLAMINE should be stored below 10° C [Bailar, 1973, vol. 2, p. 272]. Explosive reaction with strong oxidizers (chromium trioxide, potassium dichromate) or powdered zinc upon heat. Reaction with zinc or calcium produces explosive bishydroxylamides. HYDROXYLAMINE ignites on contact with cupric sulfate, alkali metals (sodium, potassium), oxidants (e.g., barium oxide, barium peroxide, lead dioxide, potassium permanganate, chlorine), phosphorus trichloride and pentachloride. HYDROXYLAMINE reacts vigorously with hypochlorites, pyridine, carbonyls [Sax, 9th ed., 1996, p. 1875]. On contact with organic materials in thin layer (e.g., crystals on filter paper), HYDROXYLAMINE may ignite spontaneously in air. HYDROXYLAMINE explodes when heated above 70° C [Brauer, 1963, vol. 1, p. 502]. During a distillation process, an explosion occurred. Potassium hydroxide is thought to be involved in the explosion. Employees in the plant complained of chest pains and suffered chemical burns. Five people were killed by the explosion.
Hazard
Decomposes rapidly at room temperature, violently when heated, detonates in flame-heated test tube. Irritant to tissue.
Health Hazard
INHALATION: Moderately toxic by inhalation and oral routes with the following symptoms possible: headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported. EYES: Corrosive - highly irritating. SKIN: Irritating or corrosive to skin. INGESTION: Moderately toxic by inhalation and oral routes with the following symptoms possible; headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported.
Contact allergens
Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.
Carcinogenicity
Carcinogenicity of hydroxylamine and its salts has not been demonstrated. Several studies have shown a decreased incidence of spontaneous mammary tumors in mice exposed to the sulfate and hydrochloride.3–7 There was some indication of an increase in the incidence of spontaneous mammary tumors when the sulfate was administered to older animals whose mammary glands were already well developed.
Environmental Fate
The large-scale production and use of hydroxylamine may
result in its release to the environment through various waste
streams. Hydroxylamine will exist solely as a vapor in the
ambient atmosphere, and will be degraded in the atmosphere
by reaction with photochemically produced hydroxyl radicals;
the half-life for this reaction in air is estimated to be 18 h.
Abiotic degradation of hydroxylamine by photochemically
produced peroxy radicals is an important environmental fate
process in surface waters, with the half-life of the reaction
measured at approximately 2 h. An estimated bioconcentration
factor of 3 suggests that the potential for bioconcentration in
aquatic organisms is low. If released terrestrially, hydroxylamine
will most likely exist in its protonated form due to its
pKa of 5.94; the protonated form is nonvolatile. Koc estimates
of 14 for hydroxylamine suggest that it may have very high
mobility in soil.
Purification Methods
Crystallise it from n-butanol at -10o, collect it by vacuum filtration and wash it with cold diethyl ether. Harmful vapours. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1932.]
HYDROXYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| Sintilla Medcoms Pvt Ltd | +91-4027808001 +91-8886733867 | Telangana, India | 307 | 58 | Inquiry |
| RPN ORGANICS PVT LTD | +919010289956 | Telangana, India | 166 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Deepak Nitrite Limited | 08069023791Ext 560 | Hyderabad, India | 84 | 58 | Inquiry |
| R. R. Group | 91-22-61207777 | Maharashtra, India | 71 | 58 | Inquiry |
| Ruchak Chemicals | 09223434848 | Mumbai, India | 62 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| RPN ORGANICS PVT LTD | 58 |
| HiMedia Laboratories | 58 |
| Deepak Nitrite Limited | 58 |
| R. R. Group | 58 |
| Ruchak Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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