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10-Hydroxycamptothecin

CAS No.: 19685-09-7

Chemical Name:: 10-Hydroxycamptothecin

Synonyms: SN38;HCPT;HYDROXYCAMPTOTHECIN;10-HCPT;(S)-10-HYDROXYCAMPTOTHECIN;Ampule;NSC 107124;HYDROCAMPTOTHECINE;hydroxy-camptotheci;Irinotecan USP RC A

CBNumber:: CB4445430

Molecular Formula:: C20H16N2O5

Molecular Weight:: 364.35

MOL File:: 19685-09-7.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 9:02:14

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10-Hydroxycamptothecin Properties

Melting point	265-270°C
Boiling point	820.7±65.0 °C(Predicted)
Density	1.60
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form	powder to crystal
pka	8.93±0.40(Predicted)
color	White to Yellow to Orange
InChIKey	HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference	19685-09-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H340

Precautionary statements

P202-P264-P270-P280-P301+P310-P405

Safety Statements

24/25

HS Code

29349990

NFPA 704

	0
2		0

10-Hydroxycamptothecin price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR2491	Irinotecan Related Compound A certified reference material, pharmaceutical secondary standard	19685-09-7	25MG	₹44804.68	2022-06-14	Buy
TCI Chemicals (India)	H1463	10-Hydroxycamptothecin	19685-09-7	1G	₹14200	2022-05-26	Buy

Product number	Packaging	Price	Buy
PHR2491	25MG	₹44804.68	Buy
H1463	1G	₹14200	Buy

10-Hydroxycamptothecin Chemical Properties,Uses,Production

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G₂/M phase.

Chemical Properties

Yellow Solid

Uses

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

10-Hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

TOPOTECANACETATE

10-Hydroxycamptothecin Suppliers

Global( 468)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Avra Laboratories Pvt Ltd	+91-8008572391 +91-8008572391	Hyderabad, India	43	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
AVRA LABORATORIES PRIVATE LTD	+91-040- 27178571	New Delhi, India	3	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
VIVAN Life Sciences Pvt. Limited.	+91(22) 2544 4584 / 2544 4585	New Delhi, India	138	50	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry

Supplier	Advantage
JSK Chemicals	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Avra Laboratories Pvt Ltd	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
AVRA LABORATORIES PRIVATE LTD	58
TCI Chemicals (India) Pvt. Ltd.	58
Manus Aktteva	34
VIVAN Life Sciences Pvt. Limited.	50
CLEARSYNTH LABS LTD.	58

10-Hydroxycamptothecin Spectrum

10-Hydroxycamptothecin(19685-09-7)¹HNMR

19685-09-7(10-Hydroxycamptothecin)Related Search:

10-HYDROXYCAMPTOTHECIN 10-Nitrocamptothecin (+)-Camptothecin Irinotecan hydrochloride 7-Ethyl-10-hydroxycamptothecin

SN-38 GLUCURONIDE sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6

Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G

Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N

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Camptothecae Acuminatae extract hydrate,(s)-dihydroxy hydroxy-camptotheci Hydroxycamptothencine (20S)-10-HYDROXYCAMPTOTHECIN 98% (20S)-10-Hydroxycamptothecin HYDROCAMPTOTHECINE CAMPTOTHECIN, 10-HYDROXY(SH) HYDROXYCAMPTOTHECIN, 10-(P) 10-hydroxycamptothecin (TECANS) 10-HYDROCAMPTOTHECIN Ampule (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione NSC 107124 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)- (4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)- (S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan USP RC A CAMPTOTHECIN, 10-HYDROXY- CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA HYDROXYCAMPTOTHECIN, 10- (20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN CaMptothecin IMpurity CaMptothecin 10-Hydroxy IMpurity 10-HydroxycaMptothecin, froM Taxus chinensis (s)-10-hydroxycamptothecinhydrate 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3 (4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione (4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-Hydroxycamptothecin 10-Hydroxycamptothecine HYDROXYCAMPTOTHECIN, 10-(RG) 10-hydroxycamptothecin,HCPT (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione Irinotecan Related CoMpound A (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione) 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-HydroxycaMptothecin, HydroxycaMptothecine 10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder Irinotecan Impurity 12 Irinotecan EP Impurity B 10-Hydroxycamptothecin 19685-09-7 (S)-4-ethyl-4,9-dihydroxy-1H-pyrano 10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B) Fructus Camptothecae Hydroxycamptothecin 80-98% (S)-10-Hydroxycamptothecin,>98% (20S)-10-Hydroxycamptothecine Camptotheca acuminata fruit extract (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione 1-Hydroxy camptothecin 10 hydroxy CamptothecinQ: What is 10 hydroxy Camptothecin Q: What is the CAS Number of 10 hydroxy Camptothecin Q: What is the storage condition of 10 hydroxy Camptothecin Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quino (1347610) (S)-10-HYDROXYCAMPTOTHECIN SN38