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Irinotecan

CAS No.: 97682-44-5

Chemical Name:: Irinotecan

Synonyms: CPT-11;IRINOTECAN HCL;CAMPTOSAR;Irinotecan(TECANS);Irinotecan (free Base);[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID;(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate;DQ-2805;SN-38-11;IRINOTECAN

CBNumber:: CB1124156

Molecular Formula:: C33H38N4O6

Molecular Weight:: 586.68

MOL File:: 97682-44-5.mol

MSDS File:: SDS

Modify Date:: 2023/9/7 18:57:57

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Irinotecan Properties

Melting point	222-223°
Boiling point	873.4±65.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.20±0.20(Predicted)
color	White to Brown
CAS DataBase Reference	97682-44-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08,GHS05
Signal word	Danger
Hazard statements	H315-H361-H302-H318-H373
Precautionary statements	P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310
Hazard Codes	Xn
Risk Statements	22
RTECS	DW1061000

Irinotecan Chemical Properties,Uses,Production

Uses

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively

Definition

ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

brand name

Camptosar (Pharmacia &Upjohn) .

Irinotecan Preparation Products And Raw materials

Raw materials

Nitrogen (+)-Camptothecin 7-Ethyl camptothecin 7-Ethyl-10-hydroxycamptothecin N-ACETYL-D-GALACTOSAMINE(GALACTOSE-13C6, 99%)

Preparation Products

Irinotecan Suppliers

Global( 408)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
J S LABS	+91-7330612784 +91-7330612784	Tamil Nadu, India	160	58	Inquiry
HRV Global Life Sciences	+91-9820219686 +91-9820219686	Telangana, India	379	58	Inquiry
Laurus Labs Ltd	+91-4066594333 +91-4039804333	Telangana, India	50	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Kekule Pharma Limited	+919849798889	Hyderabad, India	59	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Yag Mag Labs Private Limited	09346030006	Hyderabad, India	12	58	Inquiry

Supplier	Advantage
J S LABS	58
HRV Global Life Sciences	58
Laurus Labs Ltd	58
Ralington Pharma	58
Kekule Pharma Limited	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Yag Mag Labs Private Limited	58

Medical uses, Mechanism and Toxicities of Irinoteca
Irinotecan, sold under the brand name Camptosar among others, is an antineoplastic enzyme inhibitor primarily used in the trea....
Nov 14，2019

Irinotecan Spectrum

Irinotecan(97682-44-5)¹HNMR

97682-44-5(Irinotecan)Related Search:

Paclitaxel Docetaxel (+)-Camptothecin Diethyl malonate Diethyl carbonate

IRINOTECAN HCL,IRINOTECAN HYDROCHLORIDE Mefenpyr-diethyl Diethyl phthalate sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate 7,11-Diethyl-10-hydroxycaMptothecin

Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan SN-38 GLUCURONIDE 10-Hydroxycamptothecin

7-Ethylcamptothecin 7-Ethyl-10-hydroxycamptothecin Irinotecan IMpurity G

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1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester DQ-2805 (4S)-4,11-Diethyl-4-hydroxy-9-[[(4-piperidinopiperidino)carbonyl]oxy]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione SN-38-11 [1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv. Irinotecan base (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylic acid (s)-[1,4'-bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER Irinotecan Labeled d10 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2- TOPOTECIN HYDROCHLORIDE IRINOTECAN CAMPTOTHECIN 11 HYDROCHLORIDE CAMPTOTHECIN 11 HYDROCHLORIDE,TOPOTECIN Irinotecan(Cpt-11) (1,4'-Bipiperidine)-1'-carboxylicacid(S)-4,11-di] Irinotecane [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester IRINOTECAN HCL(P) [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester (9CI) Irinotecan USP/EP/BP (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate Irinotecan EP Impurity L Irinotecan Monomer Irinotecanum IrinotecanQ: What is Irinotecan Q: What is the CAS Number of Irinotecan Q: What is the storage condition of Irinotecan Q: What are the applications of Irinotecan Irinotecan (free Base) [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID CPT-11 IRINOTECAN HCL CAMPTOSAR Irinotecan(TECANS) (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate Propanamide,N-(3-bromophenyl)-8-chloro- (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate 97682-44-5 97682-44-8 C33H38N4O6 Camptothecin series APIs Natural Anti-cancer Medical Materials and It's Derivatives API's chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract API Anti cancer Inhibitors Camptosar, Campto Anti-cancer&immunity