Irinotecan
![Irinotecan Structure](CAS/GIF/97682-44-5.gif)
- CAS No.
- 97682-44-5
- Chemical Name:
- Irinotecan
- Synonyms
- CPT-11;IRINOTECAN HCL;CAMPTOSAR;Irinotecan(TECANS);Irinotecan (free Base);[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID;(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate;DQ-2805;SN-38-11;IRINOTECAN
- CBNumber:
- CB1124156
- Molecular Formula:
- C33H38N4O6
- Molecular Weight:
- 586.68
- MOL File:
- 97682-44-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/7 18:57:57
Melting point | 222-223° |
---|---|
Boiling point | 873.4±65.0 °C(Predicted) |
Density | 1.40±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 11.20±0.20(Predicted) |
color | White to Brown |
CAS DataBase Reference | 97682-44-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS07,GHS08,GHS05 |
---|---|
Signal word | Danger |
Hazard statements | H315-H361-H302-H318-H373 |
Precautionary statements | P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310 |
Hazard Codes | Xn |
Risk Statements | 22 |
RTECS | DW1061000 |
Irinotecan Chemical Properties,Uses,Production
Uses
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively
Definition
ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
brand name
Camptosar (Pharmacia &Upjohn) .
Irinotecan Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Kekule Pharma Limited | +919849798889 | Hyderabad, India | 59 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Yag Mag Labs Private Limited | 09346030006 | Hyderabad, India | 12 | 58 | Inquiry |
Supplier | Advantage |
---|---|
J S LABS | 58 |
HRV Global Life Sciences | 58 |
Laurus Labs Ltd | 58 |
Ralington Pharma | 58 |
Kekule Pharma Limited | 58 |
CLEARSYNTH LABS LTD. | 58 |
A.J Chemicals | 58 |
SynZeal Research Pvt Ltd | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Yag Mag Labs Private Limited | 58 |
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