ChemicalBook > Product Catalog >API >Antineoplastic agents >Natural sources of antineoplastic >Docetaxel
Docetaxel
- CAS No.
- 114977-28-5
- Chemical Name:
- Docetaxel
- Synonyms
- TAXOTERE;rp56976;BIND-014;Doxetaxel;Decetaxel;Anhydrous Docetaxel;Docetere;Docetaxel;Docetaxet;NSC_628503
- CBNumber:
- CB1163212
- Molecular Formula:
- C43H53NO14
- Molecular Weight:
- 807.88
- MOL File:
- 114977-28-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/10 15:15:42
| Melting point | 186-192 °C (dec.) |
|---|---|
| alpha | -36 º (c=0.74,EtOH) |
| Boiling point | 900.5±65.0 °C(Predicted) |
| Density | 1.38 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride. |
| form | Solid |
| pka | 11.20±0.46(Predicted) |
| color | White |
| Water Solubility | Soluble in dimethyl sulfoxide and ethanol. Insoluble in water. |
| Merck | 14,3397 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | BEDLLNJKXXVTSX-LWWLJZAUSA-N |
| LogP | 2.456 (est) |
| CAS DataBase Reference | 114977-28-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H341-H360D-H362-H372 |
| Precautionary statements | P202-P260-P263-P302+P352-P305+P351+P338-P308+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36/37-53-45 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | DA4172750 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29322090 |
| Toxicity | LD50 intravenous in dog: 2500ug/kg |
Docetaxel price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 01885 | Docetaxel purum, ≥97.0% (HPLC) | 114977-28-5 | 5MG | ₹15945.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 01885 | Docetaxel purum, ≥97.0% (HPLC) | 114977-28-5 | 25MG | ₹40842.73 | 2022-06-14 | Buy |
| ottokemi | D 2402 | Docetaxel+ 97% | 114977-28-5 | 5mg | ₹14004 | 2022-05-26 | Buy |
| ottokemi | D 2402 | Docetaxel+ 97% | 114977-28-5 | 25mg | ₹47079 | 2022-05-26 | Buy |
Docetaxel Chemical Properties,Uses,Production
Description
Docetaxel, a semi-synthetic product from the taxoid family, was launched in 1995 first in South Africa and subsequently in several other markets for the treatment of ovarian, breast and non-small cell lung cancers. Like the naturally occurring antitumor agent paclitaxel, the first marketed taxoid, docetaxel promotes both the rate and extent of tubulin assembly into stable microtubules and inhibits their depolymerization. It acts as a mitotic spindle poison and induces a mitotic block in proliferating cells. This mechanism of action for taxoids is unique from other classes of anticancer agents. Docetaxel was reported to be twice as potent as paclitaxel in several in vitro protocols and also exhibit higher cytotoxicity. Clinical trials are on going for docetaxel for other types of tumors including pancreatic, gastric, head and neck cancers and soft tissue sarcomas.
Chemical Properties
Off-white Cryst
Uses
Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and hormone-refractory prostate cancer. This product is intended for research applications.
Definition
ChEBI: A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.
Hazard
A poison. Human systemic effects.
Docetaxel Preparation Products And Raw materials
Raw materials
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Global( 897)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Green Vision Life Sciences Pvt Ltd. | +91-2067919200 +91-9404953243 | Maharashtra, India | 30 | 58 | Inquiry |
| Zyphars Biopharmaceuticals Pvt. Ltd | +91-8007587007 +91-8007587007 | Mumbai, India | 14 | 58 | Inquiry |
| Arch Pharmalabs Ltd | +91-2242871210 +91-2242871210 | Maharashtra, India | 51 | 58 | Inquiry |
| Basil Drugs AND Pharmaceuticals Pvt Ltd | +91-2249700250 +91-9619320820 | Mumbai, India | 108 | 58 | Inquiry |
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| AVD pharmaceuticals Pvt Ltd | 58 |
| J S LABS | 58 |
| Hetero Drugs Limited | 58 |
| Green Vision Life Sciences Pvt Ltd. | 58 |
| Zyphars Biopharmaceuticals Pvt. Ltd | 58 |
| Arch Pharmalabs Ltd | 58 |
| Basil Drugs AND Pharmaceuticals Pvt Ltd | 58 |
| Laurus Labs Ltd | 58 |
| Sakar Healthcare | 58 |
| Ralington Pharma | 58 |
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Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
Docetaxel N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
Taxotere anhydrous
n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol
)benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
ydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
DOCETAXEL ANHYDROUS 99.5%
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
docetaxcel，DTX
N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl
Docetaxel(other anti-cancers)
Docetaxel
DOCETAXEL OR TAXOTERE
NSC_628503
N-DEBENZOYL-N-BOC-10-DEACETYL TAXOL
Taxotere(R)
Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
Docetaxel9.5%
Docetaxel (Trihydrate/Anhydrous)
DOCETAXEL(P)
-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr
benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
DOCETAXEL (TAXOTERE)
DocetaxelAnhydrous/Trihydrate
DocetaxelAnhydrousin-HouseStandard
Docetaxel99.5%
[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
Docetaxel >99%
Docetaxel Anhydrous(Taxotere)
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]aMino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetraMethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyc
Benzenepropanoic acid, beta-[[(1,1-diMethylethoxy)carbonyl]aMino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano
Docetere
Docetaxel￡DOC
Decetaxel anhydrous
Docetaxet
docetaxel api
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramet
Docetaxel RS
Anhydrous Docetaxel CRS
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-ylbenzoate
TAXOTERE,DOCETAXEL
Docetaxel USP/EP/BP
Docetaxel1
Taxotere Docetaxel Powder CAS 114977-28-5
Docetaxel (RP 56976)
Docetaxel, 97%+
DocetaxelQ: What is
Docetaxel Q: What is the CAS Number of
Docetaxel Q: What is the storage condition of
Docetaxel Q: What are the applications of
Docetaxel
TAXOTERE
BIND-014
rp56976
Anhydrous Docetaxel
Doxetaxel
4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-61-THIOSEMICARBAZIDE
Methanol,6-chloro-,benzoate
Phenol,9-(bromomethyl)-,acetate