(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate

(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate Structure
CAS No.
201856-57-7
Chemical Name:
(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate
Synonyms
Docetaxel Impurity 48;Docetaxel Impurity 54;Docetaxel Intermediate I;SIDE CHAINS OF DOCETAXEL--1;(3R,4S)-3-(1-ethoxyethoxy)-4-phenyl-N-Boc-2-azetidinone;(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidin...;(3R,4S)-1-t-butoxycarbonyl-3-(2-ethoxyethoxyl)-4-phenyl-2-azetidinone;(3R,4S)-1-T-BUTOXYCARBONYL-3-(2-ETHOXYETHOXYL)-4-PHENYL-2-AZETIDINONE,98+%;(3R, 4S) -1-tert butoxycarbonyl-3- (2-ethoxyethoxy) -4-phenyl-2-propanolam;tert-butyl (3R,4S)-3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate
CBNumber:
CB9855065
Molecular Formula:
C18H25NO5
Molecular Weight:
335.39
MOL File:
201856-57-7.mol
MSDS File:
SDS

(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate Properties

Boiling point 459.6±45.0 °C(Predicted)
Density 1.16
storage temp. 2-8°C
pka -4.97±0.60(Predicted)
CAS DataBase Reference 201856-57-7(CAS DataBase Reference)

(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate Chemical Properties,Uses,Production

Uses

(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is used as a reagent in the synthesis of abeo-taxane derivatives that possess broad inhibitory effects against proliferation of colon cancer, melanoma, and renal cancer cell lines. (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is also used as a reagent in the synthesis of a novel D-ring modified Docetaxel (D494420) analogue which has proven to have equipotent cytotoxicity in relation to Paclitaxel (P132500) towards cancer cell lines.

(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-dimethylethyl ester (3r,4s)-tert-butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate (3R,4S)-1-AZETIDINECARBOXYLIC ACID-3-(2-ETHOXYETHOXY)-4-PHENYL-2-PHENYL-AZETIDIONE (3R,4S)-1-t-butoxycarbonyl-3-(2-ethoxyethoxyl)-4-phenyl-2-azetidinone (3R,4S)-1-T-BUTOXYCARBONYL-3-(2-ETHOXYETHOXYL)-4-PHENYL-2-AZETIDINONE,98+% SIDE CHAINS OF DOCETAXEL--1 (1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-dimethyl ethyl ester Docetaxel Intermediate I (3R,4S)-3-(1-ethoxyethoxy)-4-phenyl-N-Boc-2-azetidinone tert-butyl (3R,4S)-3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester 3-(1-ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid tert-butyl ester Docetaxel Impurity 48 1-Azetidinecarboxylic acid, 3-(1-ethoxyethoxy)-2-oxo-4-phenyl-, 1,1-dimethylethyl ester, (3R,4S)- Docetaxel Impurity 54 (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidin... (3R, 4S) -1-tert butoxycarbonyl-3- (2-ethoxyethoxy) -4-phenyl-2-propanolam 201856-57-7