Phenazine methosulfate
- CAS No.
- 299-11-6
- Chemical Name:
- Phenazine methosulfate
- Synonyms
- PMS;Phenazine methosuL;5-Methylphenazinium;Phenazine methosulfa;PHENAZINE METHOSULFATE;Phenazine Methoshlphate;PHENAZINE METHOSULPHATE;PHENAZINE METHOLSULPHATE;PHENAZINE METHYL SULFATE;PhenazineMethylSulfate>
- CBNumber:
- CB4315528
- Molecular Formula:
- C14H14N2O4S
- Molecular Weight:
- 306.34
- MOL File:
- 299-11-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/18 17:30:06
| Melting point | 158-160 °C (dec.)(lit.) |
|---|---|
| Density | 1.3395 (rough estimate) |
| refractive index | 1.6930 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 0.2 g/mL at 20 °C, clear, deep orange |
| form | Crystalline Powder |
| color | Dark yellow to brown or khaki |
| Water Solubility | soluble in water (approximately 200 mg/ml). |
| Sensitive | Light Sensitive |
| Merck | 14,6109 |
| BRN | 3898869 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 299-11-6(CAS DataBase Reference) |
| EPA Substance Registry System | Phenazinium, 5-methyl-, methyl sulfate (299-11-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn,T | |||||||||
| Risk Statements | 36/37/38-68-46 | |||||||||
| Safety Statements | 26-36/37/39-53-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SG1645000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Phenazine methosulfate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P9625 | Phenazine methosulfate ≥90% (UV) | 299-11-6 | 500MG | ₹3853.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9625 | Phenazine methosulfate ≥90% (UV) | 299-11-6 | 1G | ₹5693.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9625 | Phenazine methosulfate ≥90% (UV) | 299-11-6 | 5G | ₹20719.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9625 | Phenazine methosulfate ≥90% (UV) | 299-11-6 | 10G | ₹33341 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9625 | Phenazine methosulfate ≥90% (UV) | 299-11-6 | 25G | ₹64679.38 | 2022-06-14 | Buy |
Phenazine methosulfate Chemical Properties,Uses,Production
Description
Phenazine is a free radical generator. It has been used as an electron transfer reactant in cell viability assays. Phenazine (10 μM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 μM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 μM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.
Chemical Properties
orange to light brown crystals or powder
Uses
Phenazine Methosulfate is used in tyrosine transaminase test and for enzymic determination of ethanol in blood by the colorimetric micromethod. Used with ascorbic acid to determine nitric oxide reductase activity. Since the reduced PMS is easily oxidized by oxygen, it is used in assays as an electron carrier between enzymes and oxygen, cytochrome c, indophenols, or tetrazolium salts. The reduced PMS is used as an electron donor to reduce cytochrome c or in photosynthetic experiments. Usage of PMS for detection of specific dehydrogenases has been reported.
Definition
ChEBI: 5-methylphenazinium methyl sulfate is an azaheterocycle sulfate salt and a member of phenazines. It is used as an electron carrier in place of the flavine enzyme of Warburg in the hexosemonophosphate system and also in the preparation of succinic dehydrogenase. Green et al., J. Biol. Chem. 217, 551 (1955).
Application
Phenazine methosulfate is a compound used to determine nitric oxide reductase activity. Phenazine methosulfate has been used:
as a component of succinate dehydrogenase enzyme substrate solution.
to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability.
as a component of complex II histochemistry media.
Used in the discovery of potent bromophenazine antibacterial agents against Staphylococcus.
General Description
Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.
Purification Methods
It forms yellow-brown prisms from EtOH (charcoal), or EtOH/Et2O. Its solubility in H2O at 20o is 10%. In the presence of aqueous KI it forms a semiquinone which crystallises as blue leaflets from EtOH. [Wieland & Roseen Chem Ber 48 1117 1913, Voriskova Collect Czech Chem Commun 12 607 1947, Bülow Chem Ber 57 1431 1924, Campbell et al. J Chem Soc 404 1938, Morley J Chem Soc 4008 1952, Beilstein 23 I 59, 23 II 234, 23 III/IV 1658, 23/8 V 395.]
Phenazine methosulfate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Innovative | 07942565925 | Mumbai, India | 617 | 58 | Inquiry |
| Loba Chemie Pvt., Ltd. | 91-22-66636663 | Maharashtra, India | 766 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| A.J Chemicals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Central Drug House(P) Ltd. | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Triveni chemicals | 58 |
| Innovative | 58 |
| Loba Chemie Pvt., Ltd. | 58 |
| Anand Agencies | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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