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Fursultiamine

CAS No.: 804-30-8

Chemical Name:: Fursultiamine

Synonyms: ttfd;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin;alinaminf;Aliaron F;fursultiamin

CBNumber:: CB1161096

Molecular Formula:: C17H26N4O3S2

Molecular Weight:: 398.54

MOL File:: 804-30-8.mol

MSDS File:: SDS

Modify Date:: 2024/3/26 14:13:49

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Fursultiamine Properties

Melting point	130-136°C (decompos.)
Boiling point	652.3±55.0 °C(Predicted)
Density	1.29
refractive index	1.6270 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form	Solid
pka	14.42±0.10(Predicted)
color	White to Off-White
CAS DataBase Reference	804-30-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Toxicity	LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine Chemical Properties,Uses,Production

Description

Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.

Chemical Properties

white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.

Uses

Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.

Application

Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.

Preparation

Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.

Fursultiamine Preparation Products And Raw materials

Raw materials

2-Acetylbutyrolactone Acrylonitrile Dimethyl sulfate Thiamine hydrochloride Sodium hydroxide

Preparation Products

Fursultiamine Suppliers

Global( 160)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ami Lifesciences Pvt Ltd	+91-9426998100 +91-9426998100	Gujarat, India	62	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Shandong Natural Micron Pharm Tech Co.,LTD	+86-18653895227	China	94	58	Inquiry
Wuhan Qiami Technology Co., Ltd	+8618062705058	China	148	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	6011	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	China	1807	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry

Supplier	Advantage
Ami Lifesciences Pvt Ltd	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Shandong Natural Micron Pharm Tech Co.,LTD	58
Wuhan Qiami Technology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58

804-30-8(Fursultiamine)Related Search:

Methylene dithiocyanate Methylparaben Acetonitrile Paraquat dichloride DL-Dithiothreitol

Methanol Methyl acrylate 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Dimethyl disulfide Furan

CHLOROPHOSPHONAZO III Kresoxim-methyl Selenium sulfide Basic Violet 1 Methyl

Fursultiamine HCL JP Thiamine chloride Thiamine disulfide

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((tetrahydrofurfuryl)dithio)-1-butenyl)- adventan alinaminf diteftin fursultiamin n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide Fursutiamine Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI) Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]- N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide Retar B1 Tetrahydrofurfuryl thiamine disulfide Thiamin tetrahydrofurfuryl disulfide N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide Fursultiamine (base and/or unspecified salts) N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahyclrofurfury(dithio-1-bute Fursultiamine###Fursultiamine Hcl FURSULTIAMINE Fursultiamine Base Fursultiaminlim N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma FURSULTIAMINE HYDROCHLORIDE Aliaron F Alinaxin N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide judolor linamin retar-b(sub1) thiaminetetrahydrofurfuryldisulfide ttfd Fursultiamine Hydrochloride RS Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]- THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD) Fursultiamine USP/EP/BP Fursultiamine HCL JP USP/EP/BP Derivative Fursultiamine N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide Furan thiamine 804-30-8 C17H26N4O3S2 Vitamins and derivatives