Thiamine chloride
- CAS No.
- 59-43-8
- Chemical Name:
- Thiamine chloride
- Synonyms
- Vitamin B1;thiamin;VITAMIN B1(THIAMINE)(BASF)(SH);aneurine;ViatmineB1;THIAMIMEMONOCHLORIDE;VITAMIN B1(THIAMINE)(SH);Thiamine chloride vitamin B1;Vitamin B1 Mononitrate (Mono);b-amin
- CBNumber:
- CB0154385
- Molecular Formula:
- C12H17ClN4OS
- Molecular Weight:
- 300.81
- MOL File:
- 59-43-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 13:37:16
| Melting point | 248 °C (decomp) |
|---|---|
| Density | 1.3175 (rough estimate) |
| refractive index | 1.5630 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO : 6 mg/mL (19.95 mM) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1 |
| InChIKey | MYVIATVLJGTBFV-UHFFFAOYSA-M |
| SMILES | O([H])CCC1=C(C)[N+](=CS1)CC1C=NC(=NC=1N)C.[Cl-] |
| LogP | -3.930 (est) |
| CAS DataBase Reference | 59-43-8(CAS DataBase Reference) |
| EPA Substance Registry System | Thiamine (59-43-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
| Hazardous Substances Data | 59-43-8(Hazardous Substances Data) |
Thiamine chloride Chemical Properties,Uses,Production
General Description
Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases.
Biological Activity
Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP).
TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):
This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment.
Clinical Use
Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent.
Safety Profile
Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.
Thiamine chloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Gloria Interchem Pvt Ltd | +91-9825029521 +91-9825029521 | Gujarat, India | 49 | 58 | Inquiry |
| PROTECH TELELINKS | +91-8571891912 +91-9855060837 | Himachal Pradesh, India | 62 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Mau Crops | 08048371779Ext 488 | Uttar Pradesh, India | 1 | 58 | Inquiry |
| Aurora Industry Co., Ltd. | +86-13591747876 +86-13591747876 | China | 299 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | China | 8808 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12809 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Besil Chem LLP | 58 |
| Gloria Interchem Pvt Ltd | 58 |
| PROTECH TELELINKS | 58 |
| Medilink Pharmachem | 50 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Mau Crops | 58 |
| Aurora Industry Co., Ltd. | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | 58 |