Vitamin B12
- CAS No.
- 68-19-9
- Chemical Name:
- Vitamin B12
- Synonyms
- CYANOCOBALAMIN;Vb12;METHYLCOBALAMIN;CYANOCOBALAMINE;hemomin;cyanocobalamin (b12);COBALAMINE;hydroxycobalamin chloride;VIT B12;lldfactor
- CBNumber:
- CB6126463
- Molecular Formula:
- C63H88CoN14O14P
- Molecular Weight:
- 1355.37
- MOL File:
- 68-19-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/15 19:00:21
| Melting point | >300°C |
|---|---|
| alpha | 23656 -59 ± 9° (dil aq soln) |
| Boiling point | >300 °C |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic. |
| pka | pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain) |
| form | Crystalline Powder or Crystals |
| color | Red to dark red |
| Odor | dark red cryst. or powd., odorless and tasteless |
| Water Solubility | Soluble |
| Sensitive | Hygroscopic |
| Merck | 14,10014 |
| BRN | 4122889 |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| Stability | Hygroscopic. Keep cold and dry. |
| InChIKey | RMRCNWBMXRMIRW-WZHZPDAFSA-L |
| LogP | 3.570 (est) |
| EPA Substance Registry System | Vitamin B12 (68-19-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | ||||||||||
| HS Code | 2936260000 | |||||||||
| Toxicity | LD50 intravenous in mouse: 2gm/kg | |||||||||
| NFPA 704 |
|
Vitamin B12 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V6629 | Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98% | 68-19-9 | 100MG | ₹4622.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V6629 | Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98% | 68-19-9 | 250MG | ₹6765.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V6629 | Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98% | 68-19-9 | 1G | ₹18575.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V2876 | Vitamin B12 ≥98% | 68-19-9 | 100MG | ₹1796.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V2876 | Vitamin B12 ≥98% | 68-19-9 | 250MG | ₹2987.7 | 2022-06-14 | Buy |
Vitamin B12 Chemical Properties,Uses,Production
Chemical Properties
Dark red, crystalline powder or dark red crystals.
History
VITAMIN B12 (Cobalamin), Sometimes also called cyanocobalamin, this vitamin is one of the more recent of the major B complex vitamins to be fully identified, with its structure not definitized (by Hodkin et al.)
Uses
Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesi zed almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.
Production Methods
Vitamin B12 dietary supplements are often prepared commercially by the fermentation of S. griseus, S. aureofaciens, Propionibacterium; or as a by-product of antibiotic production.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cyanocobalamin, also known as vitamin B12, belongs to a group of organic compounds important for the normal growth and development of human and animal bodies. It is used for the treatment of trigeminal neuralgia and multiple sclerosis.
Health Hazard
Deficiency diseases or disorders include retarded growth; pernicious anemia; megaloblastic anemia; macrocytic, hyperchromic anemia; glossitis; spinal cord degeneration; and sprue.
Biological Activity
Principal physiological functions include: (1) Coenzyme in nucleic acid, protein, and lipid synthesis; (2) maintains growth; (3) participates in methylations; (4) maintains epithelial cells and nervous system (myelin sheath); (5) erythropoiesis (with folic acid); (6) leukopoiesis.
Safety Profile
Poison by subcutaneous route. Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of POx and NOx. See also COBALT COMPOUNDS.
Vitamin B12 Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CRYSTAL PHARMA | +91-9322218073 +91-9820141331 | Mumbai, India | 106 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| Triveni Interchem Private Limited | +91-02606618618 +91-7574814001 | Gujarat, India | 42 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Believe Pharma | +91-9376562200 +91-7990821661 | Gujarat, India | 19 | 58 | Inquiry |
| Supreem Pharmaceuticals Mysore Pvt Ltd | +91-9449813468 +91-9741498883 | Karnataka, India | 13 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
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