Mecobalamin
- CAS No.
- 13422-55-4
- Chemical Name:
- Mecobalamin
- Synonyms
- METHYLCOBALAMIN;MECOBALAMINE;methylcobalamine;methycobal;Mecobalamin Tablets;vitamin B12 Mecobalamin;Mecobalamin(Methylcobalamin);Methyl-5,6-dimethylbenzimidazolylcobalamin;MeCbl;mbl-a
- CBNumber:
- CB1106194
- Molecular Formula:
- C63H90CoN13O14P
- Molecular Weight:
- 1343.4
- MOL File:
- 13422-55-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | >190°C (dec.) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Sparingly), Water (Slightly) |
| pka | pK1:7.64(+1) (25°C) |
| form | Solid |
| color | Dark Red |
| Odor | Odorless |
| Water Solubility | Partially soluble in cold water, hot water. |
| Stability | Light Sensitie |
| InChIKey | JEWJRMKHSMTXPP-WYVZQNDMSA-L |
| LogP | -2.812 (est) |
| CAS DataBase Reference | 13422-55-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GG3745000 | |||||||||
| HS Code | 29362600 | |||||||||
| Toxicity | LD50 oral in rat: > 5gm/kg | |||||||||
| NFPA 704 |
|
Mecobalamin price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M9756 | Methylcobalamin vitamin B12 analog | 13422-55-4 | 25MG | ₹9136.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9756 | Methylcobalamin vitamin B12 analog | 13422-55-4 | 100MG | ₹10272.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9756 | Methylcobalamin vitamin B12 analog | 13422-55-4 | 250MG | ₹23544.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9756 | Methylcobalamin vitamin B12 analog | 13422-55-4 | 1G | ₹71336.75 | 2022-06-14 | Buy |
Mecobalamin Chemical Properties,Uses,Production
Description
Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
Chemical Properties
Dark Red Crystalline Powder
Physical properties
Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above
300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water
and are fairly stable to heat but decompose at temperatures above ～210 °C without
melting.
Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent
degradation of the former, which releases its cobalt atom as the free ion. Cobalamins
are more stable in the presence of ascorbic acid but unstable to light
Uses
One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).
Definition
A vitamin B 12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated to methanearsonic acid then to cacodylic acid.
Side effects
Common side effects of Mecobalamin include: vomiting, diarrhoea, nausea, headache and loss of appetite. Rarely, hypotension, hypokalaemia and thrombocytosis occur. Serious allergic reactions are rare, contact your doctor if you experience hives, difficulty breathing, swelling of the face, lips, tongue or throat, difficulty breathing.
Mecobalamin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Organo Chem (India) | +91-8459110412 +91-9810846377 | Uttar Pradesh, India | 21 | 58 | Inquiry |
| Prachi Pharmaceuticals Pvt Ltd | +919004877711 | Mumbai, India | 36 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| Deccan Nutraceuticals Pvt. Ltd | +91-9822641298 +91-9822641298 | Mumbai, India | 18 | 58 | Inquiry |
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Supriya Lifescience Ltd | +91-9820804279 +91-9821266261 | Maharashtra, India | 27 | 58 | Inquiry |
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