Ascorbic Acid
- CAS No.
- 50-81-7
- Chemical Name:
- Ascorbic Acid
- Synonyms
- ASCORBIC ACID;VITAMIN C;L-ASCORBIC ACID;Ascorbate;ascorbic;L-ASCORBATE;(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one;ASCOBIC ACID;3-Keto-L-gulofuranolactone;Ascorb
- CBNumber:
- CB7853704
- Molecular Formula:
- C6H8O6
- Molecular Weight:
- 176.12
- MOL File:
- 50-81-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | 190-194 °C (dec.) |
|---|---|
| alpha | 20.5 º (c=10,H2O) |
| Boiling point | 227.71°C (rough estimate) |
| Density | 1,65 g/cm3 |
| FEMA | 2109 | ASCORBIC ACID |
| refractive index | 21 ° (C=10, H2O) |
| storage temp. | Store at +5°C to +30°C. |
| solubility | H2O: 50 mg/mL at 20 °C, clear, nearly colorless |
| form | powder |
| pka | 4.04, 11.7(at 25℃) |
| color | white to slightly yellow |
| PH | 3.59(1 mM solution);3.04(10 mM solution);2.53(100 mM solution); |
| Odor | Odorless |
| PH Range | 1 - 2.5 |
| optical activity | [α]25/D 19.0 to 23.0°, c = 10% in H2O |
| Odor Type | green |
| Water Solubility | 333 g/L (20 ºC) |
| Merck | 14,830 |
| BRN | 84272 |
| BCS Class | 1 |
| Stability | Stable. May be weakly light or air sensitive. Incompatible with oxidizing agents, alkalies, iron, copper. |
| InChIKey | CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
| LogP | -1.85 |
| CAS DataBase Reference | 50-81-7(CAS DataBase Reference) |
| NIST Chemistry Reference | L-Ascorbic acid(50-81-7) |
| EPA Substance Registry System | Ascorbic acid (50-81-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338-P370+P378 | |||||||||
| Hazard Codes | ||||||||||
| Risk Statements | ||||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CI7650000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29362700 | |||||||||
| Toxicity | LD50 oral in rat: 11900mg/kg | |||||||||
| NFPA 704 |
|
Ascorbic Acid price More Price(102)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W210901 | L-Ascorbic acid FCC, FG | 50-81-7 | 1SAMPLE | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W210901 | L-Ascorbic acid FCC, FG | 50-81-7 | 1KG | ₹8865.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W210901 | L-Ascorbic acid FCC, FG | 50-81-7 | 10KG | ₹39478.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W210901 | L-Ascorbic acid FCC, FG | 50-81-7 | 25KG | ₹76283.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V-038 | L-Ascorbic acid solution 1.0?mg/mL in acetonitrile: water, certified reference material, Cerilliant? | 50-81-7 | 1ML | ₹8032.15 | 2022-06-14 | Buy |
Ascorbic Acid Chemical Properties,Uses,Production
Description
Ascorbic acid, a water-soluble dietary supplement, is consumed by humans more than any other supplement. The name ascorbic means antiscurvy and denotes the ability of ascorbic to combat this disease. Vitamin C is the l-enantiomer of ascorbic acid. Ascorbic acid deficiency in humans results in the body’s inability to synthesize collagen, which is the most abundant protein in vertebrates.
Chemical Properties
White crystals (plates or needles). Soluble in water; slightly soluble in alcohol; insoluble in ether, chloroform, benzene, petroleum ether, oils and fats. Stable to air when dry. One international unit is equivalent to 0.05 milligram of l-ascorbic acid.
Physical properties
Appearance: white crystal or crystalline powder, and it is odorless and flavors sour. The color changes yellowish when exposed in the air for a long time. Its aqueous solution is acidic reaction. Solubility: vitamin C is soluble in water, slightly soluble in ethanol, and insoluble in chloroform or ether. Melting point: 190–192? °C.? It would decompose when it melts. Specific optical rotation: +20.5 to +21.5°. Ascorbic acid is two-base acid (the pKa is 4.1 and 11.8). It occurs mainly in the form of sodium salt and calcium salt, and its aqueous solution is strongly acidic reaction. Ascorbic acid is a strong reducing agent.
History
Vitamin C is a general term for compounds having ascorbic acid activity, including ascorbic acid, dehydroascorbic acid, and its isomers.
The understanding of vitamin C has gone through a long and painful process. Although the relationship between scurvy and stored food is obvious, but the
treatments of this disease have been misguided. By 1601, British armed Captain
James Lancaster discovered the disease on the ship of the East India Company and
regarded the scurvy as “rot,” which could be made tissue alkaline.
At the early stage of the nineteenth century, the understanding and treatment of scurvy had developed to a right approach. The exposition of
scurvy etiology and metabolic theory took more than a century.
By the early stage of the twentieth century, inspired by the animal model of beriberi, researchers in the Christchurch Oslo University discovered one animal that
could suffer scurvy accidentally and then established a valuable scurvy animal
model. This experiment demonstrated that the extract isolated from lemon had antiscurvy activity. Until 1932, many research groups obtained the anti-scurvy crystal
from different plants and identified the crystal as ascorbic acid vitamin C. Next year,
the chemical structure of ascorbic acid was elucidated, and then its artificial synthesis was accomplished.
Uses
antiscorbutic, antiviral
Indications
Vitamin C (ascorbic acid) is essential for the maintenance of the ground substance that binds cells together and for the formation and maintenance of collagen.The exact biochemical role it plays in these functions is not known, but it may be related to its ability to act as an oxidation–reduction system.
Definition
ChEBI: L-ascorbic acid is the L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate. It has a role as a coenzyme, a flour treatment agent, a food antioxidant, a plant metabolite, a cofactor, a skin lightening agent and a geroprotector. It is an ascorbic acid and a vitamin C. It is a conjugate acid of a L-ascorbate. It is an enantiomer of a D-ascorbic acid.
General Description
White to very pale yellow crystalline powder with a pleasant sharp acidic taste. Almost odorless.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light. Sensitive to moisture. Soluble in water. Aqueous solutions are oxidized by air in a reaction that is accelerated by alkalis, iron and copper. The rate depends on the pH and on oxygen concentration. Also subject to degradation under anaerobic conditions.
Reactivity Profile
L(+)-Ascorbic acid is a lactone. Reacts as a relatively strong reducing agent and decolorizes many dyes. Forms stable metal salts. Incompatible with oxidizers, dyes, alkalis, iron and copper. Also incompatible with ferric salts and salts of heavy metals, particularly copper, zinc and manganese .
Fire Hazard
Flash point data for L(+)-Ascorbic acid are not available; however, L(+)-Ascorbic acid is probably combustible.
Pharmacology
Vitamin C is considered as a classical enzyme cofactor or antioxidant but also as a transition material in metal ion reaction. And all of these functions of vitamin C are related to the property of antioxidation.
Clinical Use
Vitamin C is indicated for the treatment and prevention of known or suspect deficiency. Although scurvy occurs infrequently, it is seen in the elderly, infants, alcoholics, and drug users.Ascorbate can also be used to enhance absorption of dietary nonheme iron or iron supplements. Ascorbic acid (but not the sodium salt) was historically used to acidify the urine as a result of excretion of unchanged ascorbic acid, although this use has fallen into disfavor. Ascorbate also increases iron chelation by deferoxamine, explaining its use in the treatment of iron toxicity.
Side effects
Megavitamin intake of vitamin C may result in diarrhea due to intestinal irritation. Since ascorbic acid is partially metabolized and excreted as oxalate, renal oxalate stones may form in some patients.
Toxicology
L-Ascorbic acid, or vitamin C, is widely present in plants. The structures of ascorbic acid and dehydroascorbic acid are shown in Figure 10.5. Vitamin C is not only an important nutrient but is also used as an antioxidant in various foods. However, it is not soluble in fat and is unstable under basic conditions. Vitamin C reduces cadmium toxicity and excess doses prolong the retention time of an organic mercury compound in a biological system. Overdoses of vitamin C (106 g) induce perspiration, nervous tension, and lowered pulse rate. WHO recommends that daily intake be less than 0.15 mg/kg. Toxicity due to ascorbic acid has not been reported. Although repeated intravenous injections of 80 mg dehydroascorbic acid was reported to be diabetogenic in rats, oral consumption of 1.5 g/day of ascorbic acid for six weeks had no effect on glucose tolerance or glycosuria in 12 normal adult males and produced no change in blood glucose concentrations in 80 diabetics after five days. The same report noted that a 100-mg intravenous dose of dehydroascorbic acid given daily for prolonged periods produced no signs of diabetes. Ascorbic acid is readily oxidized to dehydroascorbic acid, which is reduced by glutathione in blood.
Safety Profile
Moderately toxic by ingestion and intravenous routes. Human systemic effects by intravenous route: blood, changes in tubules (including acute renal failure, acute tubular necrosis). An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise it from MeOH/Et2O/pet ether [Herbert et al. J Chem Soc 1270 1933]. [Beilstein 18/5 V 26.]
Ascorbic Acid Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| Shreenath Chemicals | +91-8369634120 +91-8369634120 | Maharashtra, India | 48 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Organo Chem (India) | +91-8459110412 +91-9810846377 | Uttar Pradesh, India | 21 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| ANWITA APIS | 58 |
| Anant Pharmaceuticals Pvt Ltd | 58 |
| ADVENT CHEMBIO PRIVATE LIMITED | 58 |
| AMINO ORGANICS | 58 |
| Shreenath Chemicals | 58 |
| JSK Chemicals | 58 |
| Medi Pharma Drug House | 58 |
| Organo Chem (India) | 58 |
| Bajaj Healthcare Ltd | 58 |
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