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D-Biotin

D-Biotin Structure
CAS No.
58-85-5
Chemical Name:
D-Biotin
Synonyms
BIOTIN;VITAMIN B7;VITAMIN H;5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanoic acid;BIOEPIDERM;5-(2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;BIOS H;BIOTINUM;BIOTIN(V-H);ETHYLPHENYLETHANOL
CBNumber:
CB3271542
Molecular Formula:
C10H16N2O3S
Molecular Weight:
244.31
MOL File:
58-85-5.mol
MSDS File:
SDS
Modify Date:
2024/9/4 23:37:13
Request For Quotation

D-Biotin Properties

Melting point 231-233 °C(lit.)
alpha 89 º (c=1, 0.1N NaOH)
Boiling point 573.6±35.0 °C(Predicted)
Density 1.2693 (rough estimate)
refractive index 90.5 ° (C=2, 0.1mol/L NaOH)
storage temp. -20°C
solubility H2O: 0.2 mg/mL Solubility increases with addition of 1 N NaOH.
form powder
pka 4.74±0.10(Predicted)
color White crystalline powder or fine long needles
PH 4.5 (0.1g/l, H2O)
optical activity [α]20/D +91±2°, c = 1% in 0.1 M NaOH
Water Solubility Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.
Sensitive Light Sensitive
Merck 14,1231
BRN 86838
Stability Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids, formaldehyde, chloramine-T, nitrous acid.
InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
LogP 0.861 (est)
CAS DataBase Reference 58-85-5(CAS DataBase Reference)
NIST Chemistry Reference Biotin(58-85-5)
EPA Substance Registry System Biotin (58-85-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  1
RTECS  XJ9088200
F  8
TSCA  Yes
HS Code  29362930
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
NFPA 704
0
1 0

D-Biotin price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B4639 Biotin powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99% 58-85-5 100MG ₹4167.63 2022-06-14 Buy
Sigma-Aldrich(India) B4639 Biotin powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99% 58-85-5 500MG ₹9406.93 2022-06-14 Buy
Sigma-Aldrich(India) PHR1233 Biotin Pharmaceutical Secondary Standard; Certified Reference Material 58-85-5 1G ₹11138.93 2022-06-14 Buy
Sigma-Aldrich(India) B4639 Biotin powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99% 58-85-5 1G ₹15447.28 2022-06-14 Buy
Sigma-Aldrich(India) B4501 Biotin ≥99% (HPLC), lyophilized powder 58-85-5 100MG ₹2760.38 2022-06-14 Buy
Product number Packaging Price Buy
B4639 100MG ₹4167.63 Buy
B4639 500MG ₹9406.93 Buy
PHR1233 1G ₹11138.93 Buy
B4639 1G ₹15447.28 Buy
B4501 100MG ₹2760.38 Buy

D-Biotin Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue.

Definition

ChEBI: An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biotin is a water-soluble vitamin, essential for amino acids and carbohydrates metabolism. It is involved in de novo synthesis of purine nucleotides and plays a role in gene expression and DNA replication.

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.

Purification Methods

D-(+)-Biotin crystallises from hot water in fine long needles with a solubility of 22 mg/100mL at 25o. Its solubility in 95% EtOH is 80 mg/100 mL at 25o. Its isoelectric point is at pH 3.5. Store solid and solutions under sterile conditions because it is susceptible to mould growth. [Confalone J Am Chem Soc 97 5936 1975, Wolf et al. J Am Chem Soc 67 2100 1945, Synthesis: Ohuri & Emoto Tetrahedron Lett 2765 1975, Harris et al. J Am Chem Soc 66 1756 1944.] The (+)-methyl ester has m 166-167o (from MeOH/Et2O), [] D 22 +57o (c 1, CHCl3) [du Vigneaud et al. J Biol Chem 140 643, 763 1941]; the (+)-S-oxide has m 200-203o, [] D 20 +130o (c 1.2, 0.1N NaOH) [Melville J Biol Chem 208 495 1954]; the SS-dioxide has m 274-275o(dec, 268-270o), and the SS-dioxide methyl ester has m 239-241o (from MeOH/Et2O) [Hofmann et al. J Biol Chem 141 207, 213 1941]. [Beilstein 27 III/IV 7979.]

D-Biotin Preparation Products And Raw materials

Raw materials

L-Cysteine Sodium hydroxide Ammonium formate

Preparation Products

L-Glutamic acid L-Lysine hydrochloride Monosodium glutamate L-(+)Sodium glutamate BIOTIN-NHS
biotinylamidoethylacetamide LC-LC(+)-Biotin N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE D-BIOTINOL (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID
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D-Biotin Suppliers

Global( 1126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Global Pharma +91-9819994077 +91-9819994077 Maharashtra, India 34 58 Inquiry
SNA HEALTHCARE PVT LTD +91-8652842416 +91-8652842416 Mumbai, India 88 58 Inquiry
SNECOFRi Pvt Ltd +91-9032850129 +91-9032850129 Telangana, India 404 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Meteoric Biopharmaceuticals Pvt. Ltd. +91-8511121361 +91-8511121361 Mumbai, India 71 58 Inquiry
Medi Pharma Drug House +919930911911 Mumbai, India 143 58 Inquiry
Supreem Pharmaceuticals Mysore Pvt Ltd +91-9449813468 +91-9741498883 Karnataka, India 13 58 Inquiry
Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) +91-1142631798 +91-9899000024 New Delhi, India 55 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
Global Pharma 58
SNA HEALTHCARE PVT LTD 58
SNECOFRi Pvt Ltd 58
JSK Chemicals 58
Meteoric Biopharmaceuticals Pvt. Ltd. 58
Medi Pharma Drug House 58
Supreem Pharmaceuticals Mysore Pvt Ltd 58
Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) 58
Clearsynth Labs 58

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D-Biotin Spectrum

D-Biotin(58-85-5)MSD-Biotin(58-85-5)1HNMRD-Biotin(58-85-5)FT-IRD-Biotin(58-85-5)RamanD-Biotin(58-85-5)IR

58-85-5(D-Biotin)Related Search:

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VITAMIN B6 HYDROCHLORIDE,VITAMIN B6, HCL BIOTINAMIDOCAPROYL HYDRAZIDE 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)-
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PHOTOPROBE(R) BIOTIN D-(+)-Biotin,98+% D-BIOTIN, 1%, 2% (VITAMIN H) (+)-Biotin , Vitamin B7, Coenzyme R 1H-Thieno3,4-dimidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)- BIOTIN,POWDER,FCC BIOTIN,POWDER,USP 5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-4-yl)pentanoic acid 1% BIOTIN 2% BIOTIN(FEEDSTUFFS GRADE) 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3aS-(3aα,4β,6aα)]- cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid Lutavit H2 Meribin Rovimix H 2 (+)-BIOTIN FACTOR S HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID COENZYME R D-(+)-Biotin Food Grade, 1% on DCP D-Biotin 1% D-Biotin Food Grade, 2%, Powder D-BIOTIN (VITAMIN H) D-BiotinForBiochemistry D-BiotinCrystalline,>99% Biotine-D D-BiotinCrystalline BiphenylForSynthesis D-Biotin,Pure,2%,1% D-Biotin(Biotin,VitaminH) VitaminHforanimalnutrition 4S,7S,8R-Hexahydro-2-oxothieno[3,4-d]imidazol-4-pentansure HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, VITAMIN H BIOTIN 1% FEED GRADE (3AS,4S,6AR)-HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID D-BIOTIN USP D(+)-Biotin >99.5% D-BIOTIN FCC (VITAMIN H) D-BIOTIN USP (VITAMIN H) D(+)-Biotin, 98% 5GR 5-(2-Hydroxy-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]iMidazol-6-yl)-pentanoic acid 3,3'-DiaMethyl-4,4'-diaMinodicyclohexylMethane(MACM) D(+)-Biotin 0 Biotin (Vitamin B7) Biotin Vetec(TM) reagent grade, >=99% 15720-24-8 1H-Thieno(3,4-d)imidazole-4-pen 3672-05-7 BSPBio_002329 DivK1c_000311 IDI1_000311 KBio2_000705 Biotine pure CIS-HEXAHYDRO-2-OXO-1H-THIENE[3,4]IMIDAZOLE-4-VALERIC ACID D-CIS-HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID D(+)-BIOTIN D-BIOTIN 5-((3AR,6S,6AS)-2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID