L-(+)Sodium glutamate

L-(+)Sodium glutamate Properties

Melting point	232°C
alpha	20 -3.5° (10% soln in 5° Bé HCl); D20 +25.16° (10g MSG/100ml 2N HCl)
Density	d20 (saturated water soln): 1.620
FEMA	2756 \| MONOSODIUM GLUTAMATE
refractive index	25 ° (C=10, 2mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in water; sparingly soluble in ethanol (95%).
form	powder
color	white to off-white
Water Solubility	>=10 g/100 mL at 20 ºC
Merck	6254
Stability	Hygroscopic
LogP	-1.44
CAS DataBase Reference	142-47-2(CAS DataBase Reference)
EPA Substance Registry System	Monosodium glutamate (142-47-2)

SAFETY

Risk and Safety Statements

Risk Statements	20/21/22
WGK Germany	2
RTECS	MA1578000
TSCA	Yes
HS Code	29224999
Toxicity	LD50 i.g. in mice: 19.9 g/kg (Eka)

L-(+)Sodium glutamate price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	V900334	L-Glutamic acid monosodium salt hydrate Vetec?, reagent grade, ≥99%	142-47-2	100G	₹2706.25	2022-06-14	Buy
Sigma-Aldrich(India)	G5889	L-Glutamic acid monosodium salt hydrate BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%	142-47-2	100G	₹3810.4	2022-06-14	Buy
Sigma-Aldrich(India)	V900334	L-Glutamic acid monosodium salt hydrate Vetec?, reagent grade, ≥99%	142-47-2	500G	₹5109.4	2022-06-14	Buy
Sigma-Aldrich(India)	G5889	L-Glutamic acid monosodium salt hydrate BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%	142-47-2	500G	₹7166.15	2022-06-14	Buy
Sigma-Aldrich(India)	G5889	L-Glutamic acid monosodium salt hydrate BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%	142-47-2	1KG	₹9558.48	2022-06-14	Buy

Product number	Packaging	Price	Buy
V900334	100G	₹2706.25	Buy
G5889	100G	₹3810.4	Buy
V900334	500G	₹5109.4	Buy
G5889	500G	₹7166.15	Buy
G5889	1KG	₹9558.48	Buy

L-(+)Sodium glutamate Chemical Properties,Uses,Production

Chemical Properties

Colorless powder

Occurrence

Reported found in certain seaweeds including Laminaria japonica

Uses

Flavor enhancer for foods in concentration of about 0.3%.

Preparation

Monosodium glutamate is commonly produced by a fermentation process using glucose (often sugar molasses) as a starting substance. Once the glucose is converted to glutamic acid, it is filtered, dissolved and converted to monosodium glutamate by neutralization with sodium hydroxide. The monosodium glutamate solution is decolorized and then crystallized, dried, sieved, packed and shipped

Production Methods

Monosodium glutamate is the monosodium salt of the naturally occurring L-form of glutamic acid. It is commonly manufactured by fermentation of carbohydrate sources such as sugar beet molasses. In general, sugar beet products are used in Europe and the USA. M 452 Monosodium Glutamate Other carbohydrate sources such as sugar cane and tapioca are used in Asia.

Definition

ChEBI: An optically active form of monosodium glutamate having L-configuration.

General Description

White or off-white crystalline powder with a slight peptone-like odor. pH (0.2% solution)7.0.

Air & Water Reactions

Water soluble.

Reactivity Profile

L-(+)Sodium glutamate is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data are not available for L-(+)Sodium glutamate, but L-(+)Sodium glutamate is probably combustible.

Pharmaceutical Applications

Monosodium glutamate is used in oral pharmaceutical formulations as a buffer and a flavor enhancer. For example, it is used with sugar to improve the palatability of bitter-tasting drugs and can reduce the metallic taste of iron-containing liquids. It has also been used in subcutaneous live vaccine injections such as measles, mumps, rubella and varicella-zoster live vaccine (ProQuad). However, the most widespread use of monosodium glutamate is as a flavor enhancer in food products. Typically, 0.2–0.9% is used in normally salted foods, although products such as soy protein can contain 10–30%. The use of monosodium glutamate in food products has been controversial owing to the apparently high number of adverse reactions attributed to the substance, which gives rise to the so-called ‘Chinese Restaurant Syndrome’.
The current consensus is that there is no clinically compelling evidence to suggest that monosodium glutamate may be harmful at the current levels used in foods.

Safety Profile

Moderately toxic by intravenous route. Mildly toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion and intravenous routes: somnolence, hallucinations and distorted perceptions, headache, dyspnea, nausea or vomiting, dermatitis. The cause of "Chnese restaurant syndrome." When heated to decomposition it emits toxic fumes of NOx and Na2O.

Safety

Monosodium glutamate is widely used in foods and oral pharmaceutical formulations. It is generally regarded as moderately toxic on ingestion or intravenous administration. Adverse effects include somnolence, hallucinations and distorted perceptions, headache, dyspnea, nausea or vomiting, and dermatitis. The lowest lethal oral dose in humans is reported to be 43 mg/kg.The use of monosodium glutamate in foods has been controversial due to the so-called ‘Chinese Restaurant Syndrome’, although it is generally regarded as safe at intake levels of up to 6 mg/kg bodyweight.In Europe, total glutamate intake from food ranges from 5–12 g/day.
There has been a report of a foreign body granuloma caused by monosodium glutamate after a BCG vaccination.

Environmental Fate

MSG is a white, odorless powder with high water solubility. If released into the air, it remains in the particulate phase until removed by deposition.

storage

Aqueous solutions of monosodium glutamate may be sterilized by autoclaving. Monosodium glutamate should be stored in a tight container in a cool, dry place.

Regulatory Status

GRAS listed. Accepted in Europe for use as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral syrup). Included in nonparenteral medicines licensed in the UK. Included in subcutaneous vaccine injections.

L-(+)Sodium glutamate Preparation Products And Raw materials

Raw materials

2-Furoic acid β-Amylase D(+)-Glucose D-Biotin Solid sodium hydroxide

L-Glutamic acid D-(+)-Maltose monohydrate alpha-Amylase Acid modified starch Molasses

Celite Sodium carbonate

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Preparation Products

N-acyl glutamate potassium salt sodium L-glutamate H-GAMMA-GLU-VAL-OH ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE

L-(+)Sodium glutamate Suppliers

Global( 401)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Foxkem Industries	08048973640	Uttar Pradesh, India	120	58	Inquiry
Kesun Global	08046072602	Nagpur, India	3	58	Inquiry
Powder Pack Chem	08046047024	Mumbai, India	191	58	Inquiry
PS Polychem	08047640351	Delhi, India	32	58	Inquiry
Trishulent India	08048272091	Mumbai, India	2	58	Inquiry
M/S Rajvi Chemical Corporation LLP	08046068343	Mumbai, India	13	58	Inquiry
MMTA Solutions Private Limited	07942550464	Uttar Pradesh, India	1	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Maas Pharma Chemicals	58
A.J Chemicals	58
Foxkem Industries	58
Kesun Global	58
Powder Pack Chem	58
PS Polychem	58
Trishulent India	58
M/S Rajvi Chemical Corporation LLP	58
MMTA Solutions Private Limited	58

L-(+)Sodium glutamate Spectrum

L-(+)Sodium glutamate(142-47-2)¹HNMR L-(+)Sodium glutamate(142-47-2)¹³CNMR L-(+)Sodium glutamate(142-47-2)IR1 L-(+)Sodium glutamate(142-47-2)IR2 L-(+)Sodium glutamate(142-47-2)Raman

142-47-2(L-(+)Sodium glutamate)Related Search:

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Hydrogen Sodium amide Folic acid Diclofenac sodium Sodium hydroxide

Sodium bicarbonate 4-Amino-benzenesulfonic acid monosodium salt L-Glutamic acid

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