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Hydroxocobalamin

Hydroxocobalamin Structure
CAS No.
13422-51-0
Chemical Name:
Hydroxocobalamin
Synonyms
hydroxycobalamin;axion;HYDROXOCOBALAMINE;hydroxycobalamine;HYDROXOCOBALAMIN VITAMIN B12;axlon;ohb12;cobalex;docclan;docelan
CBNumber:
CB6133733
Molecular Formula:
C62H90ClCoN13O15P
Molecular Weight:
1382.82
MOL File:
13422-51-0.mol
Modify Date:
2024/7/2 8:55:12

Hydroxocobalamin Properties

Melting point >300 °C
storage temp. 2-8°C
solubility methanol: 10 mg/mL at 20 °C, clear, dark red
form Solid
color Dark Brown to Black
Odor odorless
Stability Hygroscopic
InChIKey YOZNUFWCRFCGIH-ZKJXODNJNA-K
LogP -2.812 (est)
EPA Substance Registry System Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) (13422-51-0)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  GG3820000
3-8-10
Toxicity LD50 intravenous in mouse: > 50mg/kg

Hydroxocobalamin Chemical Properties,Uses,Production

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Definition

A form of vitamin B 12.

Side effects

Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare.

Hydroxocobalamin Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-(5,6-dimethylbenzimidazolyl)hydroxocobamide alphacobione alpharedisol axlon ciplaminh cobalex vitaminb(sub12a) ALPHA-(5,6-DIMETHYLBENZIMIDAZOLYL)HYDROXOCOBAMIDE HYDROCHLORIDE AQUOCOBALAMIN CHLORIDE HYDROXYCOBALAMIN HYDROCHLORIDE HYDROXOCOBALAMIN HYDROXOCOBALAMINE HYDROCHLORIDE OH-CBL HCL VITAMIN B12A VITAMIN B12A HYDROCHLORIDE VITAMIN B12B Hydroxocobalamin/VitaminB12Cp2000 α-[5,6-Dimethylbenzimidazolyl] hydroxocobamide Hydroxocobalam Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) HYDROXOCOBALAMIN,USP Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide HYDOXOCOBALAMIN hydroxycobalamin (both acetate and HCl) Hydroxocobalamin Acetate/Hydroxocobalamin HCL (Vitamin B12) ALPHAREDISOL (hydroxocobalaMin) HydroxocobalaMin (VitaMin B12a) CobinaMide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-e cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-est cobinamidehydroxidephosphate3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranos depogamma docclan docelan docelvita docevita duradoce duralta-12 erwith5,6-dimethyl-1-alpha-d-ribofuranosyl-1h-benzimidazole hydrobamine hydrocobalamin hydrogrisevit hydrovit hydroxo-cobalami hydroxocobemine hydroxyvitaminb12 hyxobamine idrogrisevit lyovit-h neo-cytamen neo-macrabin neo-rojamin ohb12 oh-duphar oxobemin oxolamine(arcum) primabaltrp redisolh