Vitamin A palmitate
- CAS No.
- 79-81-2
- Chemical Name:
- Vitamin A palmitate
- Synonyms
- RETINYL PALMITATE;RETINOL PALMITATE;Vitamin a Palmitate Oil;Vitamin A Palmitate Powder;VitaminAPalmitateinOil;Dry Vitamin A Palmitate;Retinylpalmitat;VITAMINE A PALMITATE;VITAMIN A PALMITATE Liquid;VITAMIN A PALMITATE 1.7 MIU
- CBNumber:
- CB0406543
- Molecular Formula:
- C36H60O2
- Molecular Weight:
- 524.86
- MOL File:
- 79-81-2.mol
- Modify Date:
- 2024/7/29 11:23:16
| Melting point | 28-29℃ |
|---|---|
| Boiling point | 546.51°C (rough estimate) |
| Density | 0.9668 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| Flash point | 194℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| form | oil |
| Specific Gravity | 0.90～0.93 (20℃) |
| color | Light Yellow to Yellow |
| Water Solubility | Soluble in chloroform, ether, and vegetable oils. Insoluble in water. |
| Merck | 13,10073 |
| BRN | 1917366 |
| BCS Class | 4 |
| Stability | Light Sensitive |
| InChIKey | VYGQUTWHTHXGQB-YFAKFODJSA-N |
| LogP | 15.51 at 25℃ |
| CAS DataBase Reference | 79-81-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Vitamin a palmitate(79-81-2) |
| EPA Substance Registry System | Retinol, hexadecanoate (79-81-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360D-H412 |
| Precautionary statements | P202-P273-P280-P308+P313-P405-P501 |
| Hazard Codes | T,Xn,F |
| Risk Statements | 63-53-61-11 |
| Safety Statements | 53-23-36/37/39-45-36/37-16-60 |
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution |
| WGK Germany | 3 |
| RTECS | VH6860000 |
| F | 8-10-23 |
| TSCA | Yes |
| HS Code | 29362100 |
| Toxicity | LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm) |
Vitamin A palmitate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R3375 | Retinyl palmitate Type IV, ~1,800,000?USP units/g, oil | 79-81-2 | 1G | ₹7328.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R3375 | Retinyl palmitate Type IV, ~1,800,000?USP units/g, oil | 79-81-2 | 5G | ₹23219.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R3375 | Retinyl palmitate Type IV, ~1,800,000?USP units/g, oil | 79-81-2 | 100G | ₹75309.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R1512 | Retinyl palmitate potency: ≥1,700,000?USP units per g | 79-81-2 | 5G | ₹2500.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1235 | Retinyl Palmitate (Vitamin A Palmitate) Pharmaceutical Secondary Standard; Certified Reference Material | 79-81-2 | 1G | ₹8346.08 | 2022-06-14 | Buy |
Vitamin A palmitate Chemical Properties,Uses,Production
Chemical Properties
95.0-100.5% Absorbance @325 nm ≥0.85%
Uses
vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol.
General Description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Retinyl palmitate belongs to a category of compounds called retinoids, which are chemically similar to vitamin A. It exhibits a beneficial effect on vision, skin and immune function, inhibits cell proliferation and prevents cancer. It is an important dietary as well as a therapeutic compound.
Biochem/physiol Actions
Vitamin A palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Vitamin A palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Vitamin A palmitate acts as a chemopreventive or antineoplastic agent.
Review: Vitamin A metabolism.
Side effects
Vitamin A palmitate is fat-soluble and is stored in the body's fatty tissue. Therefore, excessive levels of vitamin A palmitate can lead to toxicity and liver disease. This is more likely to occur when taking supplements than when consuming them from food. People with liver disease should not take vitamin A palmitate supplements. Excessive doses of vitamin A supplements have been linked to birth defects, including malformations of the eyes, lungs, skull and heart. They are not recommended for pregnant women. Regular high doses of vitamin A letter source can lead to depression, dry skin, and muscle and joint pain.
Safety Profile
Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
The palmitate is separated from retinol by column chromatography on water-deactivated alumina with hexane containing a very small percentage of acetone. It is also chromatographed on TLC silica gel G, using pet ether/isopropyl ether/acetic acid/water (180:20:2:5) or pet ether/acetonitrile/acetic acid/water (190:10:1:15) to develop the chromatogram. It is then recrystallised from propylene at low temperature (below -47o). [Beilstein 6 IV 4135.]
Vitamin A palmitate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CRYSTAL PHARMA | +91-9322218073 +91-9820141331 | Mumbai, India | 106 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Fermenta Biotech Limited | +91-9892659914 +91-9892659914 | Maharashtra, India | 5 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| RBL Pharma Chem Private Limited | 08047621804 | Delhi, India | 10 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Shreenath Traders | 08048961449 | Gujarat, India | 10 | 58 | Inquiry |
| Chemzone Pharma | 08048989317 | Ahmedabad, India | 18 | 58 | Inquiry |
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