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Vitamin D2

Vitamin D2 Structure
CAS No.
50-14-6
Chemical Name:
Vitamin D2
Synonyms
ERGOCALCIFEROL;VITAMIN D;CALCIFEROL;Calderol;VitaMin D2-d3;Drisdol;Doral;Crtron;Deltalin;Sterogyl
CBNumber:
CB3731934
Molecular Formula:
C28H44O
Molecular Weight:
396.65
MOL File:
50-14-6.mol
MSDS File:
SDS
Modify Date:
2024/11/15 21:27:52
Request For Quotation

Vitamin D2 Properties

Melting point 114-118 °C(lit.)
alpha 82 º (c=3, in acetone 25 ºC)
Boiling point 460.3°C (rough estimate)
Density 0.9784 (rough estimate)
vapor pressure 7 x l0-7 Pa (20 °C), est.)
refractive index 1.5100 (estimate)
Flash point 14 °C
storage temp. -20°C
solubility H2O: 200 mg/mL, clear to hazy
form powder
pka 14.74±0.20(Predicted)
color white to yellowish
optical activity [α]20/D +105±2°, c = 4% in ethanol
Water Solubility Soluble in ethanol, water, methanol, dimethylformamide, and dimethyl sulfoxide.
Merck 14,10018
BRN 1916682
BCS Class 3
Stability Light Sensitive
InChIKey MECHNRXZTMCUDQ-RKHKHRCZSA-N
LogP 10.440 (est)
CAS DataBase Reference 50-14-6(CAS DataBase Reference)
NIST Chemistry Reference Ergocalciferol(50-14-6)
EPA Substance Registry System Ergocalciferol (50-14-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H311-H330-H372
Precautionary statements  P260-P264-P280-P302+P352+P312-P304+P340+P310-P314
Hazard Codes  Xn,T+,T,F
Risk Statements  22-48/25-26-24/25-40-23/24/25-48/22-23-11-20
Safety Statements  28-36/37-45-28A-36-26-36/37/39-22-16-7
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  KE1050000
F  1-8-10
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  29362900
NFPA 704
0
4 0

Vitamin D2 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E5750 Ergocalciferol 40,000,000?USP units/g 50-14-6 1G ₹6873.88 2022-06-14 Buy
Sigma-Aldrich(India) V-024 Vitamin D2 solution 1?mg/mL in ethanol, ampule of 1?mL, certified reference material, Cerilliant? 50-14-6 1ML ₹10110.55 2022-06-14 Buy
Sigma-Aldrich(India) PHR1238 Ergocalciferol (Vitamin D2) Pharmaceutical Secondary Standard; Certified Reference Material 50-14-6 500MG ₹12048.23 2022-06-14 Buy
Sigma-Aldrich(India) E5750 Ergocalciferol 40,000,000?USP units/g 50-14-6 5G ₹18619 2022-06-14 Buy
Sigma-Aldrich(India) E5750 Ergocalciferol 40,000,000?USP units/g 50-14-6 25G ₹52620.33 2022-06-14 Buy
Product number Packaging Price Buy
E5750 1G ₹6873.88 Buy
V-024 1ML ₹10110.55 Buy
PHR1238 500MG ₹12048.23 Buy
E5750 5G ₹18619 Buy
E5750 25G ₹52620.33 Buy

Vitamin D2 Chemical Properties,Uses,Production

Description

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light. Vitamin D2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D2 is metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2. Differences in the metabolism and action of vitamin D2 vs. vitamin D3 in mammals is a current topic of research interest.

Chemical Properties

Ergocalciferol is an odorless white crystalline solid

Uses

Vitamin d2 is fat-soluble, and is stable unless oxidized. It is necessary for growth and maintenance of teeth and bones and the normal utilization of calcium and phosphorus; it is used medicinally in the treatment of rickets and as a dietary supplement. Its sources include fish liver and vitamin d-fortified milk.

Definition

ChEBI: A vitamin D supplement and has been isolated from alfalfa.

General Description

Odorless white crystals. Used as a dietary supplement and food additive.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.

Fire Hazard

Shows signs of decomposition when stored for a few days at room temperature.

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. An experimental teratogen. Human systemic effects by ingestion: anorexia, nausea or vomiting, and weight loss. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Used as a nutrient and/or dietary supplement food additive

Metabolic pathway

Ergocalciferol (vitamin D2) is a product made by the UV irradiation of yeast ergosterol. It is a common form of vitamin D and it has very similar biological activity to that of cholecalciferol (vitamin D3) in the treatment of the vitamin D deficiency diseases (e.g. rickets). The bioactive form of this vitamin is also the 1,25-dihydroxy-derivative and this has equal antirachitic activity to that of the cholecalciferol analogue (Jones et al., 1975).

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 IV 4404.]

Incompatibilities

Dust may be combustible and may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Waste Disposal

Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Vitamin D2 Preparation Products And Raw materials

Raw materials

Silica glass Cyclohexane PASSION FLOWER OIL Chloroform Ergosterol
3,5-Dinitrobenzoyl chloride Alcohol soluble Pyridine
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Preparation Products

25-HYDROXYVITAMIN D2 VitaMin D2 Tosylate (1R,3aR,7aR)-1-((2R,5S)-5,6-diMethylheptan-2-yl)-7a-Methyloctahydro-1H-inden-4-ol Vitamin D2 SO2 Adduct (3S)-1,3-Bis-O-tert-ButyldiMethylsilyl 3-Hydroxy VitaMin D2 SO2 Adduct (Mixture of DiastereoMers)
tert-Butyl-dimethyl-{3-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2l6-benzo[c]thiophen-5-yloxy}-silane
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Vitamin D2 Suppliers

Global( 716)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dishman Carbogen Amcis Ltd (Dishman Group) +91-2717420100 +91-8154017093 Gujarat, India 90 58 Inquiry
Fermenta Biotech Limited +91-9892659914 +91-9892659914 Maharashtra, India 5 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
PY Chemical Industries 08046073673 Gujarat, India 35 58 Inquiry
Quality Products Lab Private Limited 08048250471Ext 345 Uttar Pradesh, India 43 58 Inquiry
Astitva Chemicals 08048262675 Gujarat, India 89 58 Inquiry
Insta Chemi Private Limited 08048958481 Uttar Pradesh, India 122 58 Inquiry
Santo Righello Private Limited 08068970644Ext 147 Hyderabad, India 29 58 Inquiry
I A Chemicals 08048971648 Gujarat, India 24 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
Supplier Advantage
Dishman Carbogen Amcis Ltd (Dishman Group) 58
Fermenta Biotech Limited 58
CLEARSYNTH LABS LTD. 58
PY Chemical Industries 58
Quality Products Lab Private Limited 58
Astitva Chemicals 58
Insta Chemi Private Limited 58
Santo Righello Private Limited 58
I A Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58

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Arthin VD2,Ergocal ciferol ERGOCALCIFEROL (D2) 100MG NEAT ERGOCALCIFEROL, PH EUR ERGOCALCIFEROL CELL CULTURE TESTED VITAMIN D2-WATER SOLUBLE VITAMIN D2 USP CRYSTALLINE VITAMIN D2 USP, 850000 I.U. G 5,7,10(19),22-CHOLESTATETRAEN-24BETA-METHYL-3BETA-OL-9,10-SECO 5,7,10(19),22-CHOLESTATETRAEN-24B-METHYL-3B-OL-9,10-SECO Ergocalciferol (D2) Ergocalciferol/VitaminD2 Ergocalciferol(VitaminD2PowderWaterSoluble)1,500,000Iu VitaminD2Oil5,000,000Iu ERGOCALCIFEROLOIL(400,000IU) 3-[2-[1-(5,6-dimethylhept-3-en-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol VITAMIN D2(ERGOCALCIFEROL)(RG) VITAMIN D2(ERGOCALCIFEROL)(SH) 5 ampules) (Vitamin D2) Ergocalciferol (30 mg/ampule VitaMin D2, 99% 1GR VitaMin D2, 99% 5GR (5Z,7E,22E)-9,10-seco-ergosta-5,7,10(19),22-tetraen-3β-ol VitaMin D2-d6 or Ergocalciferol D6 VITAMIN D2(ERGOCALCIFEROL)(P) VitaMin D2, 40000 IU/Mg VitaMin D2 0 Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)- Vitamin D2 solution Ergocalciferol (6,19,19-d3) Ergocalciferol d6 Calciferol solution 10-Secoergosta-5,7,10,22-tetraen-3-ol Vitamin D2 〔Calciferol〕 ERGOCALCIFEROL >= 98.0% (HPLC, SUM O Irradiated rgosterol 9,10-secoergosta-5,7,10(19),22-tetra-en-3-ol 9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol, (3beta,5Z,7E,22E)- activatedergosterol Buco-D Calciferol (vitamin D2) Calciferon 2 calciferon2 component of Geltabs Vitamin D component of Haliver Condacaps Condol Daral D-Arthin Davitamon D davitamond Davitin Decaps Dee-Osterol Dee-Ron Dee-Ronal Dee-Roual minad2